nulling the Virtnulll Cell Sinulllation nullvironnullnt for
nulltracting nullantitative Paranullters fronullLive Cell
Flnullrescence Inullging Data
null null Cowannull nullnullLinullFnullnull MorgannullDnullnull nullppelnullBnullMnullSlepchennullnullLnullMnullLoewnulland null Schaff
nullenter nullnullr nullell nullnalysis and nullnulldelingnull nullniversity nullnull nullnullnnecticut nullealth nullenternull 26null nullarmingtnulln
nullve.null nullarmingtnullnnull nullnull 060null0
null
acnullnullan@nsnull2.uchc.edu
Introdnulltion reactinullnsnull and cnullmpartments. nullegmented images derived nullrnullm
nullapid advances in nullunullrescence prnullnulle and imaging technnulllnullies enulleriments are used tnull create a 2null nullr null genullmetry that matches
nnullnull prnullvide easily accessinullle tnullnullls nullnullr nullinulllnullists tnull pernullnullrm highly the enullerimental cell nullnullr direct cnullmparisnulln. nullevelnullpment nullnull the
detailed analysis nullnull mnulllecular interactinullns in living cells. nullnullnullever underlying math descriptinulln and numerical methnullds tnull snulllve the
it can nulle dinullult tnull enullract accurate parameters nullrnullm these simulatinulln are transparentnull althnullugh easily accessinullle nullnullr analysis and
enulleriments nullecause nullnull the cnullmplenull interplay nullnull dinullusinulln-reactinulln editing inull desired. nullurthermnullrenull nullnullell can impnullrt almtnull any nullind nullnull
events nullith the mnullrphnulllnully nullnull the cell. nulls a resultnull nullnly a small generic images and prnullprietary micrnullcnullpy data tnull nulle used nullithin
nullractinulln nullnull the availanullle spatinulltempnullral innullnullrmatinulln is utilinulldnull and simulatinullns tnull denulle arnullitrary nullldnull snull as the initial cnullnditinullns nullnull a
in many cases analysis remains at a nullualitative level. nulle nullirtual nullell simulatinulln. nulluch ldnull s can specinully distrinulluted parametersnull initial
(nullnullellnull
httpnullnullcell.nullrg) simulatinulln envirnullnment is uninulluely suited tnull cnullnditinullnsnull nullr even nullynull cnullmpnullnents nullnull vectnullr ldnull s cnullrrespnullnding
analynullng these types nullnull nullunullrescence imaging enulleriments nullecause tnullnull nullnullr enullmplenull cytnull eletal nullrganinulltinulln. nullith nullnullellnull a user can
it is designed tnull snulllve reactinulln-dinullusinulln enulluatinullns nullithin any given predict the spatinulltempnullral distrinullutinulln nullnull all mnulllecular species
genullmetry nullnull given nullull innullnullrmatinulln anullnullut initial distrinullutinullnsnull mnulldel parametersnull
nullnullell is a prnullnulllem-snulllving envirnullnment nullnullr analysisnull mnulldelingnull enullernal stimulinull and the cellular genullmetry.
and simulatinulln nullnull cell nullinulllnullical prnullcesses nullithin realistic genullmetries. nullany nullnullell mnulldels punulllished nully the nullenter nullnullr nullell nullnalysis
nullnullell integrates a grnullnulling range nullnull mnulllecular mechanismsnull including and nullnulldeling (nullnullnull and nullthers nullere created tnull simulate specinull
reactinulln nullineticsnull dinullusinullnnull null null memnullrane transpnullrtnull lateral enullerimental situatinullns. nullmnull ples include mnulldels tnull analynull cellular
memnullrane dinullusinullnnull and electrnullphysinulllnully. nullt can assnullciate these enullects nullnull uncaging nullnull enulleriments pernullnullrmed using tnulltal internal
mechanisms nullith genullmetries derived nullrnullm enullerimental micrnullcnullpe renullctinulln nullptics nullnull unullnull rescence nullsnull in nullhnulltnullnullleaching (nullnull)
images. nullt is a nullenullnullasednull client-server systemnull nullith mnullre than tnullnull enulleriments tnull assess memnullrane assnullciatinulln nullnull the small nullnullase
thnullusand nullnullrldnullide users. nulle user internullce allnullnull enullerimentalists rac nullnull translnullcatinulln nullnull a nullnull-tagged plectnull rin hnullmnulllnully dnullmain
tnull input a physinulllnullical mnulldel in easily understnullnulld terms nullnull speciesnull sensnullr nullnullr nullnull2 and nullnull nullnull and unullnull rescence nulledistrinullutinulln anuller
nullhnulltnullnullleaching (nullnull) studies nullnull tight
nullunctinulln cnullmpnullnents nullnull nulle client-
server architecture nullnull nullnullell prnullvides
the innullrastructure nullnullr maintaining
mnulldels nullithin a nullnullell datanullasenull manulling
mnulldels easily accessinullle nullnullr re-use nully
the investigatnullr nullrnull inull punulllishednull nully the
scientinull cnullmmunity. snull manulles it
relatively straightnullnullrrnull d nullnullr investigatnullrs
tnull mnulldinully enullsting mnulldels and apply them
tnull the genullmetry nullnull their nullnulln enullerimental
cells.
nulllthnullugh nullnullell is a pnullnullernullul general-
purpnulle simulatinulln tnullnulllnull light-nulleight
tnullnulllnullnullnulles nullprtiminulld nullnullr specinull rnullutine
data analyses cnulluld nulle nullnull help. nulle are
therenullnullre develnullping a suite nullnull applicatinulln-
specinull tnullnullls nullased nulln nullnullell technnulllnully
tnull nullcilitate data analysis. snull prnullnullectnull the
nullnullirtual nullicrnullcnullpy nulluitenullnull nullill cnullntain
a series nullnull applicatinullnsnull each directed
at a single analysis missinullnnull and they
nullill nulle enulleriment-centric rather than
mnulldel-centric. nullese tnullnullls nullill renulluire that
Fignulle null A Virtual Cell model used to simulate nullotonullleacnullnnullenulleriments, desinulled to determine tnull nullnetics
nulle develnullp nenull algnullrithms nullnullr directly
onullnullotein bindinnullto snullcinull nuclear domains.
cnullmparing and nullptiminullng simulatinullns
36
doinullnull.nullnullnullnullnull929null999nullnull
www.microscopy-today.com null nullnull nullvenuller
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