Design and Validation of a Low-Cost Microscope for
Diagnostics in the Developing World
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null-nullevnull nullesign nullnullr the nullther nullinety nullercentnull 6null1 nullmersnulln nulltreetnull nullalnull nullltnullnull nullnull 94null01
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nullepartment nullnull nullathnulllnullgynull nulltannullnullrd nullniversity nullchnullnulll nullnull nulledicinenull null00 nullasteur nullrivenull nullane 2null5null nulltannullnullrdnull nullnull 94null05
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Introdnulltion high-dispersinulln hnulllnullraphic dinulluser nulllm nullere used tnull prnullduce
nullany innullectinullus diseases prevalent in the develnullping nullnullrldnull
1.4 numerical aperture nullnullhler-enulluivalent illuminatinulln. nullnullr
including malaria and tunullerculnullisnull are dinullult tnull diagnnulle nulln
epi-nullunullrescence imagingnull a 460-nm nulllue nullnullnull matched
the nullasis nullnull symptnullms alnullne nullut can nulle accurately detected
nullith dichrnullic and cnulllnullred glass nullltersnull is lnullcated in the nulllacnull
using micrnullcnullpe enullminatinulln. nullurrently the enullensenull sinullnull
hnullrinullntal cnullmpnullnent tnull nullhich the nnullepiece and mnullnnullcular
and nullragility nullnull nullptical micrnullcnullpes impede their nullidespread
are attached. nulle eyepieces and nullnullnullectives are interchangeanullle
use in resnullurce-limited settings. nullddressing these nulltnull acles
nullith nullthers that meet the nullnull standardnull and a nullinnullcular head
nullcing micrnullcnullpy in the develnullping nullnullrld is a pressing neednull
is nnullnull availanullle. nullnullmpnullnents nullnullr the initial 25 prnulltnulltypes
nullver 800null00 penullplenull primarily children in nullnullricanull die annually
nullere designed nully nullnullev and custnullm machined in nullalinullnullrnia.
nullnull malarianull and mnullre than 1null00null00 penullple die annually
nulleaders nullnull the prnullnullect are nnullnull seenulling a manunullcturer nullnullr
nullnull tunullerculnullis nullnull2null nulle aim nullnull this study is tnull design and
vnulllume prnullductinulln.
validate a micrnullcnullpe nullnullr use in the develnullping nullnullrld that
enull e pathnulllnullists and tnullnull micrnullnullinulllnullists evaluated the
cnullmnullines high-resnulllutinulln imagingnull enullreme anullnullrdanullilitynull and
pernullnullrmance nullnull the scnullpe in the diagnnullis nullnull sinull unnullnnullnulln slides
lnullng-term duranullility.
cnullntaining nullright-nulliemsa stained peripheral nulllnullnulld smears
Methods
nullnullr nullright-nullld detectinulln nullnull plasnullodiunull (malarial parasites)null
nulln nullptical micrnullcnullpe nullith nullright-nullld and
nullinynullun stained sputum smears nullnullr nullright-nullld detectinulln nullnull
epi-nullunullrescence capanullilities snull designed nullith a 10null nullcular nullyconullacteriunulltunullerculosisnull and auramine null stained sputum
and 10null 40null and 100null (nullil immersinulln) nullnullnullectives (nulligure 1). smears nullnullr nullunullrescent detectinulln nullnull nullyconullacteriunulltunullerculosis
nullnullr nullright-nullld imagingnull light emitting dinulldes (nullnulls) and (nulligure 2).
nullsnullts
A nullll nullve pathnulllnullists and micrnullnullinulllnullists made the cnullrrect
diagnnullis nulln all sinull unnullnnullnulln slides used nullnullr initial validatinulln
B
Fignullre nullnull (Anull nullrototnullnulle onull tnulle comnullact, lonullnullcost microsconulle nullitnull botnull brinullnulltnullnulleld and enullinullnulluorescence illumination. nullBnull nullrototnullnulle microsconulle nenullt to Ninullon nullclinullse nullnullnull00.
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www.microscopy-today.com null nullnull nullvenuller
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