search.noResults

search.searching

dataCollection.invalidEmail
note.createNoteMessage

search.noResults

search.searching

orderForm.title

orderForm.productCode
orderForm.description
orderForm.quantity
orderForm.itemPrice
orderForm.price
orderForm.totalPrice
orderForm.deliveryDetails.billingAddress
orderForm.deliveryDetails.deliveryAddress
orderForm.noItems
TABLETING


SIGNAL CONDITIONER


Te function of the signal conditioner is to amplify the transducers small millivolt signal. Tis assembly requires a power supply, amplifier, analogue to digital converter, and filters.


INSTRUMENTATION SOFTWARE Te software of an R&D tablet press should provide a user interface that monitors real-time in-process data and records a large of amount of data in an organized manner. Some software packages, such as Natoli’s AIM Data Acquisition & Analysis software for R&D tablet presses, provide graphical plots to evaluate a formulation’s tabletability, compressibility and compactibility. An example of the compressibility profile plot is displayed in Fig. 5. Tis program is also equipped for press-to-press emulation, where it will match the compression event of two different machines, which is a valuable tool for the scale-up process.


SINGLE STATION INSTRUMENTATION During the early product development stage, an instrumented single station tablet press (Fig. 2) will help characterise material deformation properties that can, in turn, allow science-based decisions in the formulation development process (illustrated in Fig. 3). A single station tablet press consists of one upper and lower punch and the die. One advantage of the single station tablet press is that it only requires a few grams of material. Instrumentation for single station tablet presses should include upper and lower punch force, ejection and residual radial die wall force, take-off sticking force, punch displacement, and temperature.


Another type of single station tablet


press is a compaction emulator that is designed to match the compression times of a high-speed manufacturing rotary tablet press. Fig. 4 depicts an example of a compaction emulator. Te emulator obtains all the instrumentation benefits of a single station tablet press, but it also provides this data at matched compression times of a high-speed rotary press. Fig. 7 depicts representable data from an instrumented single station tablet press and emulator.


ROTARY PRESS INSTRUMENTATION Te next step in the development process is to transfer the product to an instrumented small-scale rotary tablet press (see Fig. 1). Tese machines are a scaled-down version of the manufacturing press and only require a few hundred grams of


Fig. 4. Compaction emulator


material. Tis allows the study of the product behaviour throughout the complete rotary press cycle. Data obtained from this step includes compaction profiles and strain rate scalability studies, as displayed in Fig. 6. Te instrumentation on a rotary press includes pre- and main


Fig. 3. Characterising deformation properties based off Heckel plots www.scientistlive.com 47


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72