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ANALYTICAL AND LABORATORY EQUIPMENT


PRECISE GAS CONTROL for FERMENTATION


respective general requirements. Above all, the precise regulation of gas quantities in fermentation processes must be adapted to the needs of the constantly increasing cultures. Bürkert Fluid Control Systems has launched mass flow controllers (MFCs) featuring a wide adjustment range, excellent repeat accuracy and documentation functions for reproducible processes. The devices comply with the approvals USP Class VI, FDA, 3.1 certificate and EC 1935. The mass flow controllers are suitable for


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use in research laboratories right up to pilot plants. A total of four different gases can be calibrated. With just one device, the user is able to control the common fermenter gases such as air, oxygen, nitrogen or carbon dioxide exactly according to the needs of the respective cultures. The MFCs Type 8741 and 8745 (image) cover standard flow ranges for nitrogen from 0.010 to 160 lN/min and from 20 to 2500 lN/min. The wetted parts are made of stainless steel to prevent ferment contamination. The


he challenge when producing bacteria, fungi or cell cultures lies in the exact adherence to the


mass flow controllers therefore comply with the approvals USP Class VI, FDA, 3.1 certificate and EC 1935. Thanks to direct


measuring sensors, the MFCs with high repeat accuracy are also suitable for the smallest gas quantities. In combination with the integrated, direct-acting proportional valve, they enable very dynamic control. Process data such as gas pressure and gas flow rate can be transmitted variably in conjunction with the Bürkert EDIP (Efficient Device Integration Platform). The MFCs also support Industrial Ethernet, PROFINET, EtherNet/IP, EtherCAT, Modbus TCP or CANopen as well as Profibus-DP via a gateway. In addition, Bürkert also offers ready-assembled compact system solutions. The pre-configured complete systems, consisting of MFCs and valves, can be easily


WALK-AWAY PROCESS DEVELOPMENT


esearchers at TauRx Therapeutics are using the automation capabilities of the Syrris Atlas HD reactor systems to simplify and accelerate process development for their product pipeline. Based at the company’s primary research facilities at the University of Aberdeen, Scotland, the Syrris


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equipment is an integral part of the quality by design (QBD) process optimisation workflow. Process chemist Scott Clunas explains:


“We have been using Altas syringe pumps and software for a number of years. This combination of pumps and automation software is very flexible, allowing us to add multiple reagents to a reactor vessel at set intervals, without needing to have somebody at the bench to manually add liquids or swap lines. We have been happy with the robustness and performance of the pumps, so when we were looking to invest


16 www.scientistlive.com


in additional batch reactor systems, Syrris was the logical choice. “We now have four Atlas HD jacketed


reactor systems, set up as two parallel pairs each controlled by a single PC, allowing us to more quickly and easily perform QBD studies for the production of our active pharmaceutical ingredients. Each of these experiments can run for 24 to 48 hours, so it’s essential that we can automate the entire reaction. The Atlas reactor systems ensure that each experiment is performed in exactly the same way every time eliminating the variability associated with manual processes giving us a very high degree of process control for consistent results and, ultimately, more robust processes,” he concludes.


For more information visit www.syrris.com


integrated into existing plants as customer- specific gas mixing units. The unit is already factory tested for tightness, pressure and correct electrical function, thereby saving valuable installation time and simplifying engineering tasks.


For more information visit www.burkert.com


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