Laboratory Products 57 New detergent line for enhanced virus inactivation and compliance


Merck, a leading science and technology company, has introduced its innovative Deviron™ detergent portfolio. This new line of detergents is designed to be more effective than conventional virus inactivation methods and to facilitate compliance with evolving regulatory standards.


Virus inactivation plays a crucial role in ensuring the safety of pharmaceutical molecules by eliminating the risk of viral contamination. Detergent treatments disrupt the lipid membrane of enveloped viruses, leading to their inactivation, a pivotal step in viral clearance.


For many years, Triton™ X-100 has been a widely used and highly effective detergent for virus inactivation and cell lysis. However, the European Commission prohibited the unauthorised use of Triton™ X-100 detergent in the European Union from January 2021 due to its listing in REACH Annex XIV in 2017.


Merck’s Deviron detergents are among the first REACH-compliant alternatives available for Triton™ X-100. These detergents demonstrated a 74% degradation within 28 days according to the OECD 301B CO2 Evolution Test Merck’s Emprove®


Evolve program offers comprehensive documentation for high-quality raw materials like the Deviron™ C16 detergent, which is used in the early stages of pharmaceutical and biopharmaceutical manufacturing. This documentation aids customers in conducting quality risk assessments and complying with evolving regulatory requirements for critical raw materials.


More information online: ilmt.co/PL/Ne2D


Colour-coded 96-well skirted PCR plates


61559pr@reply-direct.com Advancing spatial biology with powerful multi-omics profiling tools


Leading provider of life sciences products and services, AMSBIO, has introduced a tailored service offering access to a suite of powerful spatial biology multi-omics profiling tools.


The NanoString GeoMx DSP, a flexible multi-omics platform, ensures reliable quantitative assessment of spatial heterogeneity in various sample types. It eliminates the need for prequalification and addresses challenges associated with compromised sample data, providing scientists with a ground-breaking solution that integrates in situ visualisation with molecular profiling technologies. This approach allows researchers to seamlessly integrate workflows with existing histology methods, generating robust and reproducible spatial omics data efficiently.


For those seeking to visualise protein and whole transcriptome expression, AMSBIO presents the 10x Visium Digital Spatial Gene Expression. This tool streamlines experimentation with a ready-to-use workflow that integrates smoothly into existing laboratory methods. 10x Visium enables a holistic view of disease complexity, facilitating the discovery of new biomarkers, mapping spatial organisation in cell atlases, and identifying spatiotemporal gene expression patterns.


Azenta Life Sciences announces the availability of its popular FrameStar®


96-well Skirted PCR plate


in a spectrum of colours, including purple, blue, clear, green, red, black, and white. This diverse range of colours facilitates visual identification in multi-user laboratories, catering to the needs of busy pathology, molecular diagnostics, and academic labs.


In environments where various users or distinct assay types require differentiation, the introduction of coloured FrameStar®


plates proves


to be a valuable asset. Assigning specific colours to individual users or distinct assay categories streamlines PCR sample scheduling, providing a quick overview of running samples and those awaiting processing on the thermocycler.


Manufactured from virgin polymer and free from DNase, RNase, human genomic DNA, and endotoxin/pyrogen, the FrameStar®


96-well


Skirted PCR plates feature uniform ultra-smooth polypropylene tubes, ensuring optimal PCR and real-time (RT-qPCR) results with every use.


Specifically designed for low-volume PCR applications with reaction volumes below 20µl, the plate’s low-profile wells reduce the ‘dead space’ between the heated lid of the thermal cycler and the sample. This design minimises condensation formation on the tube’s side wall, preventing PCR volume reduction and enhancing reaction efficiency.


The rigid polycarbonate frame of the FrameStar® 96-well PCR plate offers enhanced mechanical stability, eliminating warping and distortion during PCR, making it an ideal choice for integration with robotic systems. Additionally, the plate’s thermal stability ensures excellent seal integrity, minimal sample evaporation, and consistent PCR results.


Further customisable options for the FrameStar® 96-well Skirted PCR plate include barcoding, ethylene oxide sterilisation treatment, an extra rigid skirt for robotic system compatibility, and an ultra-low DNA binding option for applications demanding maximum DNA recovery.


To request a free sample plate please visit ilmt.co/PL/bVv9


More information online: ilmt.co/PL/92nR 61721pr@reply-direct.com


Introducing the 10x Xenium, a powerful end-to-end spatial platform that enables high-throughput subcellular mapping of thousands of RNA targets alongside multiplexed proteins in the same tissue section. With advanced targeted high-plex in situ analysis, 10x Xenium provides scientists with subcellular resolution and unprecedented depth analysis, allowing them to explore samples in the context of their spatial localisation patterns. This advanced analysis not only helps locate and type cells within their biological context but also addresses questions about cell–cell communication, profiles cellular microenvironments, and identifies rare cell infiltration.


These revolutionary spatial biology multi-omics profiling tools from AMSBIO represent a paradigm shift in biomedical research, empowering researchers to explore tissue heterogeneity intricacies and answer critical biological questions with precision and efficiency.


For laboratories interested in adopting these ground-breaking spatial biology techniques, AMSBIO offers expert application support, guidance, and assistance with data analysis through its knowledgeable technical team.


More information online: ilmt.co/PL/Lo3D 61661pr@reply-direct.com


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