43 Sample Preparation & Processing The unmatched standard in reproducible sample homogenisation


For nearly 50 years, Retsch’s Ultra Centrifugal Mills have set the benchmark for sample homogenisation, serving quality control labs globally. The latest ZM 300 model combines German engineering excellence, premium materials, intelligent accessories, and cutting-edge software.


With an impressive speed of 23,000 rpm, the ZM 300 outperforms traditional centrifugal mills, typically limited to 18,000 rpm. Prioritising operator convenience and safety, this powerful mill delivers exceptional grinding results, producing particles 15 to 20% finer than conventional rotor mills, depending on the material. The high speed also allows for an increase of sample throughput by 10 to 15%.


Notable features include a variable speed range for optimal adaptation to sample requirements, minimising grinding time and moderating temperature increase. Excessive heat, which can negatively impact results, is controlled, especially crucial for materials with moisture or volatile components.


The ZM 300 incorporates an integrated temperature sensor near the ring sieve, displaying real-time temperature on the mill’s interface. This feature empowers users to fine-tune the grinding process, enhancing reproducibility.


Watch the video: ilmt.co/PL/xzqQ More information online: ilmt.co/PL/OvEX


61795pr@reply-direct.com Accelerated photoredox catalysis using high-intensity light source


Uniqsis has released an application report showcasing the efficiency of their new high-intensity Borealis™ LED light source in expediting metal-catalysed photoredox reactions. Building upon the Nobel Prize-winning research by Macmillan et al, photoredox catalysis has become an important strategy in chemical synthesis. Uniqsis addresses the need for practical, user-friendly benchtop photoreactor systems key to implementing this methodology in laboratories.


The Borealis™ LED light source, available in activation wavelengths ranging from 365nm to 525nm, has proven its efficacy in performing photochemical reactions in both batch and flow modes. Uniqsis has recently introduced a high-intensity variant of the 180W Borealis LED light source. This upgraded version employs high-output LEDs that, surpassing the efficiency of the original Chip-on-Board (COB) LEDs, generate increased light output while maintaining the same power consumption.


The application report focuses on two time-studies conducted in a Uniqsis Solstice 12-position multi-tube batch photoreactor, with the sole variable being the


version of the 420nm Borealis LED lamp. In each instance, the LED light source was linked to a 180W Borealis digital power supply. The results highlight how the augmented photon flux delivered by the new 420nm 180W Borealis LED lamp significantly enhances the rate of a metal-mediated photoredox decarboxylative arylation (Macmillan reaction)


compared to the original Mk1 version. Read application report 33 ‘Accelerated Metal-mediated Photocarboxylative Arylation’ in full. More information online: ilmt.co/PL/Ovd6


61882pr@reply-direct.com IR hotplate/stirrer delivers superior heating and mixing


The latest infrared heating technology has been used in the design of the WH280-NH hotplate-stirrer from Wiggens. Thanks to this radiation heating technology, the Wiggens WH280-NH can be used for rapid heating up of various shaped vessels, including round-bottom flasks, and the solution inside can be heated up to a maximum of 450°C in a very short time.


The new Wiggens hotplate stirrer enjoys the benefits of a Schott glass ceramic surface with exceptional chemical resistance, a high surface quality, and a resistance to temperature shocks of more than 700°C, providing users with an optimal solution compared to conventional heating surface materials. The poreless smooth surface enables even the most stubborn dirt to be easily cleaned. The high infrared permeability ensures that the heating energy is transferred quickly and with very limited loss, therefore, it heats liquids fast and saves time and energy. Intelligent Cascade Control enables self-optimising to reach perfect temperature stability. If the Pt-100 sensor is connected, temperature-controlled work with stability of +/- 2°C can be reached in most applications.


In addition to rapid heating capability and superior temperature control, the WH280-NH also offers well controlled gentle to intense mixing of liquids, and is also suitable for large volume viscous media.


The stirring and heating can be controlled separately by convenient turning knobs. All functions can be viewed and monitored on a bright touch screen, including most frequently used parameters, such as, working temperature, stirring speed, working time, and safety temperature. Memory function for stirring speed and temperature setting makes it convenient to start the experiments with fixed conditions. A residual-heat display protects the users from burning their hands.


With the aforementioned benefits, and many other features, the Wiggens hotplate stirrer is the optimal solution for heating and mixing of liquids in labs, for gentle to intense applications. More information online: ilmt.co/PL/gP3P and ilmt.co/PL/Q2Qe


59072pr@reply-direct.com New peptide synthesiser revolutionises drug development cycle times


Cutting-edge Solid Phase Peptide Synthesiser (SPPS) from Vapourtec drastically shortens drug development cycles, reducing production times for target peptides from weeks to under a day compared to conventional batch methods at room temperature.


Unveiled after two years of collaborative efforts with a major global pharmaceutical company, Peptide-Pilot operates efficiently within a synthesis scale ranging from 2.0 mmol to 30.0 mmol. Utilising Vapourtec’s Variable Bed Flow Reactor (VBFR), it consistently delivers high-quality crude peptides on a large scale.


State-of-the-art peptide synthesis software, equipped with a sequence generator facilitating easy programming, including automated side-chain addition, reduces the typical reaction time for a 30-mer peptide at a 20 mmol scale to under 16 hours. Minimising solvent and reagent usage, the Peptide-Pilot achieves solvent consumption of less than 70 ml per mmol/cycle, even with PEG resins.


Duncan Guthrie, Founder and MD of Vapourtec, highlighted the significance of this innovation, stating: “There’s been a notable surge in the development and utilisation of peptide drugs in recent years. Peptides are gaining prominence as therapeutic agents due to their unique properties, reduced toxicity, versatility, and


potential to address a myriad of medical conditions.


“Vapourtec’s technology and instruments have been used for lab scale peptide synthesis for the last 5 years, but our Peptide-Pilot represents a true revolution by dramatically reducing drug development timescales by up to 3 weeks when significant quantities of a target peptide are required.”


Dr Manuel Nuño, a key contributor to the synthesiser’s development, described the Peptide-Pilot as a ‘marvel of engineering’ and a ‘game-changer’ in peptide drug development, delivering cycle times that are a fraction of existing batch-based methods.


Designed for fluorenylmethoxycarbonyl protecting group (Fmoc) SPPS with DIC and oxyma activation, the synthesiser offers continuous in-line analytics, encompassing resin solvation and UV absorption data. The predictability of scaling up is emphasized, with a synthesis optimiszed on Vapourtec’s Peptide-Explorer at 0.1 mmol seamlessly transferable to the Peptide-Pilot at a 30 mmol scale without further development.


More information online: ilmt.co/PL/4mv7 61897pr@reply-direct.com


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