Laboratory Products 37 Optimise biomanufacturing with simplified cell analysis and sorting


Strain improvement and bioprocess monitoring are key factors in successful biomanufacturing processes, having significant impact on yields, operational efficiency, and overall economic viability. To master these factors, manufacturers require advanced technologies that both streamline processes and are easy to learn for inexperienced users.


The SH800 Cell Sorter from Sony Biotechnology emerges as a transformative solution, empowering users to accelerate strain improvement and simplify bioprocess monitoring. At the core of its capabilities lies the revolutionary Sorting Made Simple™ technology, positioning the system as a user-friendly gateway to the gold standards of flow cytometry and cell sorting, often considered too complex.


The SH800 system’s standout feature is its innovative microfluidic chip, a technology that ensures effortless, precise, and contamination-free sorting during strain selection and improvement. This technology not only enhances the accuracy of the process but also contributes to the overall reliability of the outcomes. The system’s advancements in high-throughput operations and consistently high-viability sorting empower users with rapid and unbiased measurements, crucial for comprehensive characterisation and stringent quality control measures.


The user-friendly design extends beyond hardware to the intuitive software of the SH800 system. Combined with advanced automation setup and calibration, the software significantly reduces the learning curve for the team. Together, these features ensure that the analysis of microbial samples becomes a seamless and efficient endeavour, promoting a smoother integration of the SH800 system into a biomanufacturing workflow.


In essence, the SH800 system transforms the landscape of strain improvement and bioprocess monitoring, making these critical factors more accessible and user- friendly for both seasoned professionals and new users alike.


More information online: ilmt.co/PL/yzpG 61903pr@reply-direct.com


Tips for moisture measurement using Karl Fischer titration


Karl Fischer titration is an analytical technique used to quantify a sample’s water content using a highly selective chemical reaction. First popularised in the mid-20th century, Karl Fischer titration has become widely applied in the quality control of petroleum, industrial chemicals, pharmaceuticals, and the like. It is also used in the R&D of substances related to the development of new materials and energy alternatives. In Karl Fischer titration, water is extracted from a sample preparation and measured after a subsequent chemical reaction. Samples, whether in liquid, gas, powder, or pellet form, are all easy to measure with high precision. However, caution must be observed for both the pH of the Karl Fischer reaction, and for the use of samples containing substances known to interfere with it.


The ideal pH range to conduct Karl Fischer reactions is pH5.5 to pH8. The lower the pH, the slower the reaction proceeds, whereas reactions performed at too high a pH tend to generate side reactions. Measurement in both situations invites the possibility of significant measurement errors. KEM suggest adding neutralising agents such as imidazole and salicylic acid to highly acidic and highly basic samples respectively, making sure to adjust the pH of the sample-containing Karl Fischer reagent in the measurement cell.


False positive errors may occur with samples containing ketones because they produce water after reacting with alcohols such as methanol present in some Karl Fischer reagents, so please use a Karl Fischer reagent designed for use with ketones.


With analysis requiring chemical reactions, it is crucial to know the chemical composition and characteristics of your sample in advance. If you have questions regarding Karl Fischer moisture titration, please contact KEM’s friendly consultants.


More information online: ilmt.co/PL/WeYM and ilmt.co/PL/ebxb 61318pr@reply-direct.com ADVERTORIAL


Revolutionising tumour screening with lab-on-chip technology


Advancements in sustainable laboratory sterilisation with eco-friendly benchtop autoclaves


In the realm of laboratories and research facilities, the quest for eco-conscious and cost-effective solutions has taken centre stage. Astell Scientific has been a pioneer in this domain, championing energy-efficient small capacity sterilisers for nearly a quarter century. Their commitment aligns seamlessly with the growing emphasis on minimising carbon footprints and utility expenses within these industries.


Astell’s Benchtop autoclave range stands as a testament to their dedication to sustainability. These autoclaves, available in 33, 43, and 63-litre chamber capacities, introduce both Classic and ‘Autofill’ versions, designed to cater to diverse operational needs. The ‘Autofill’ feature, a game-changer introduced in the early 2000s, not only offers convenience but significantly reduces water consumption, a crucial factor amid increasing environmental concerns.


Glasgow-based company, ScreenIn3D, highlights their distinctive lab-on-a-chip technology, which empowers cancer researchers to miniaturise their examination of biopsy tissue samples across an extensive array of modalities. This innovation also facilitates the evaluation of both individual and combined drug treatments on viable tissue samples.


By harnessing the latest advances in microfluidics and 3D cell culture, ScreenIn3D’s unique chip technology empowers researchers to conduct scores of 3D cancer screening experiments using as few as 1000 cells. Backed by investments from Gabriel Investments Ltd, Scottish Enterprise, and the University of Strathclyde’s Entrepreneurial Fund, ScreenIn3D is poised to enhance the platform’s capabilities for testing novel tumour indications and to scale up chip production. This expansion aims to extend the platform’s availability to pharmaceutical and biotech firms seeking to license the technology for internal utilisation. The integration of this ground-breaking technology into testing protocols holds the potential to revolutionise pharmaceutical companies’ capacity to rapidly assess drug effectiveness on patient-derived tumours. This advancement amplifies their initiatives by generating more physiologically relevant data, setting it apart from conventional biopsy approaches reliant on non-viable or deceased cells.


More information online: ilmt.co/PL/lZEj 61056pr@reply-direct.com


What distinguishes Astell’s Ecofill Benchtop autoclaves is their independence from plumbing requirements. These units solely necessitate a single-phase power supply and an integral water reservoir fill, enabling up to 15 cycles without the need for refilling. Functioning as a reservoir and collector for condensate and residual water, these autoclaves exhibit minimal water usage, positioning themselves as one of the most environmentally friendly options in the market.


The unique design of the pressure vessel ensures optimal water usage, leading to reduced power consumption and swift heating and cooling cycles, slashing cycle durations by as much as 50% when compared to similar models. This, coupled with the Autofill water recirculation system, cements Astell’s benchtop autoclaves as leaders in energy and water efficiency, resonating with the modern drive toward sustainability.


Astell’s Ecofill autoclaves symbolise a commitment to creating economically viable, environmentally conscious, and user- friendly sterilisation solutions. As the only UK manufacturer of benchtop sterilisers fitting a 5.7-inch colour touchscreen as standard, Astell provides not just cutting-edge technology but also enhanced safety and efficiency. Users gain the flexibility to monitor sterilisation cycles in real-time, customise cycle parameters, and access historical data for up to 5000 cycles, ensuring both transparency and control.


In essence, Astell’s dedication to advancing sterilisation technology not only meets but exceeds the demands of the modern era. These autoclaves stand as a testament to innovation and sustainability, shaping the future of laboratory sterilisation. For more insights into these ground-breaking advancements, visit Astell.com and witness first-hand how these autoclaves are revolutionising laboratory sterilisation.


More information online: ilmt.co/PL/8xb6 and ilmt.co/PL/XOJV 61837pr@reply-direct.com


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