31 Proteomics, Genomics & Microarrays


Precision PCR starts with smarter plates


Reliable PCR and qPCR results depend on more than just enzymes and primers - the quality of your consumables can make or break an assay. Azenta Life Sciences has developed its 4titude® range of PCR plates, engineered to deliver consistency, flexibility, and efficiency across a wide range of thermal cycling workflows.


Produced from high-purity virgin polypropylene in an ISO Class 7 cleanroom, these 96- and 384-well plates are available in a choice of low- or high-profile formats and a variety of skirted styles to suit most thermocyclers. Their ultra-thin walls enable fast, even heat transfer for consistent amplification, while raised well rims promote secure sealing and reduce the risk of cross-contamination or evaporation.


Plate colour matters - especially in real-time PCR. While clear wells are ideal for manual pipetting and sample visibility, they often compromise fluorescence detection. To overcome this, 4titude® offers white-well plates that boost signal intensity and reproducibility - critical for detecting low-copy targets or borderline positives.


To address instrument compatibility issues sometimes caused by white wells, Azenta also provides frosted-well plates. These deliver improved signal reflection over clear wells, without triggering readout errors in sensitive qPCR systems.


For added flexibility, divisible plates let users snap off sections for smaller-scale runs, cutting down on plastic waste and saving costs. And with a range of frame colours and well finishes - clear, frosted, or white - labs can organise workflows at a glance and minimise handling errors.


Whether you’re scaling up for high-throughput assays or optimising conditions for a single critical target, 4titude® PCR plates are designed to bring greater reliability to every reaction. More information online: ilmt.co/PL/Lw3b


64685pr@reply-direct.com High-sensitivity system transforms mass quantitation in complex omics


SCIEX has launched the ZenoTOF 8600 system at ASMS 2025, offering a significant advance in accurate mass quantitation for researchers working across proteomics, metabolomics, and lipidomics. Combining high sensitivity with expanded software capabilities, the new platform enables scientists to confidently quantify thousands of molecular species from complex biological samples in short acquisition times.


The ZenoTOF 8600 builds on SCIEX’s decades of innovation in mass spectrometry, incorporating new hardware to boost ion generation and transmission. The OptiFlow Pro source, along with DJet and QJet ion guides, improves ion throughput and, when used with the Zeno trap, delivers up to tenfold greater sensitivity compared to the ZenoTOF 7600+. A new optical detector supports higher ion currents, while Mass Guard technology - originally introduced on the SCIEX 7500+ - reduces contamination and improves instrument uptime.


The system also debuts ZT Scan DIA 2.0, an upgraded data acquisition method that expands mass range coverage and enhances performance across all omics disciplines. According to Dr Nicola Zamboni, Principal Investigator at ETH Zurich, “We’re not just detecting more compounds - we’re identifying up to 40% more. ZT Scan DIA 2.0 gives us access to new layers of biological insight, particularly for lipids and complex natural products.”


To support the high data throughput of the ZenoTOF 8600, SCIEX OS 4.0 introduces faster, more automated workflows for efficient processing. The updated software ecosystem also supports third-party integration. New collaborations include MS-Dial, which now supports SCIEX raw data in multiple scan modes, enhancing small molecule identification via spectral deconvolution. In proteomics, SCIEX continues its partnership with Bioinformatics Solutions Inc, whose PEAKS Studio 13 provides expanded peptide and PTM identification, optimised for ZT Scan DIA, SWATH DIA, and DDA data.


“The ZenoTOF 8600 and its supporting tools are already making a real difference in omics research,” said Dr. Jose Castro-Perez, Vice President of Product Management at SCIEX. “We’re excited by the depth of insight our customers are starting to uncover.”


More information online: ilmt.co/PL/px06 64922pr@reply-direct.com


Fast-track neural cell production with iPSC differentiation kits


AMSBIO has launched a comprehensive range of Quick-Neuron™ differentiation kits, designed to simplify and accelerate the generation of specific neural cell types from human induced pluripotent stem cells (iPSCs). These kits provide researchers with a fast, consistent, and animal-free approach to producing high-purity neurons - enabling more efficient disease modelling, drug screening, and regenerative medicine studies. Each kit includes a streamlined, highly reproducible protocol that allows users to generate functional neural cell types within just 1–2 weeks. The easy-to-follow workflows are ideal for labs seeking standardisation without compromising cell quality or reproducibility. Importantly, the differentiation process avoids the use of animal-derived materials and leaves no genetic footprint, thanks to a proprietary non-integrating transcription factor-based method available in either Sendai virus or synthetic mRNA format.


For added convenience, AMSBIO also offers a range of pre-differentiated cell lines – both diseased and healthy controls – for each neuron type, allowing users to bypass the initial iPSC steps if desired. The Quick-Neuron™ Excitatory Differentiation Kit produces high-purity glutamatergic neurons expressing key markers including TUBB3 and vGLUT1. These neurons exhibit typical neurite outgrowth, and electrophysiological analysis via patch clamp confirms spontaneous action potential generation.


The Dopaminergic Differentiation Kit enables rapid mRNA-driven production of dopaminergic neurons expressing TH and TUBB3. Likewise, the GABAergic Differentiation Kit delivers robust populations of inhibitory neurons within 10 days, validated by expression of appropriate markers and neuronal morphology. AMSBIO also supplies ready-made human iPSC-derived GABAergic neurons for immediate use.


Rounding out the collection, the Cholinergic Differentiation Kit allows for fast and efficient generation of cholinergic neurons expressing TUBB3 and ChAT, supporting applications in both neurodegenerative disease research and drug development. All kits are based on human iPSCs made under licence from the California Institute for Regenerative Medicine (CIRM), providing quality and consistency aligned with translational research goals. These versatile, scalable tools empower researchers working at the interface of neuroscience, genomics, and biotechnology to produce defined human neural cells quickly and reliably - all without relying on animal models.


More information online: ilmt.co/PL/6Rd0 65013pr@reply-direct.com


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