Proteomics, Genomics & Microarrays


Ready-to-use DUB assay kits for targeted enzyme analysis


AMSBIO has introduced a new series of Deubiquitinating (DUB) enzyme assay kits that streamline the analysis of DUB activity in both purified systems and cell-based models. Supplied in a convenient 96-well plate format, these ready-to-use kits eliminate the need for substrate preparation - making them ideal for routine use in high-throughput screening and academic research.


Deubiquitinating enzymes are central regulators of the ubiquitin-proteasome system, controlling protein stability and function in key cellular pathways such as autophagy, DNA repair, immune signalling, and cell proliferation. With around 100 known DUBs involved in both normal physiology and disease mechanisms - including cancer, neurodegeneration, and inflammation - they represent promising targets for therapeutic intervention.


Each AMSBIO DUB assay kit uses a ubiquitin-based substrate labelled with a fluorophore, enabling sensitive and specific detection of enzyme activity via a microplate reader (excitation: 485 nm, emission: 535 nm). Kits are available for a variety of disease-relevant enzymes, including BAP1, USP7, and UCHL1, supporting precise profiling and inhibitor screening efforts.


Designed for both kinetic and endpoint analysis, these assay kits require minimal setup and deliver robust, reproducible results. Researchers in drug discovery, molecular biology, and cellular signalling can now accelerate their workflows while maintaining high data quality.


Applications include studies in tumour suppression, neurodegenerative disease mechanisms, immune response regulation, and more. More information online: ilmt.co/PL/qVlb


64684pr@reply-direct.com


Automation-ready tools for PCR purifi cation workfl ows


Integra Biosciences is helping labs streamline efficiency and consistency in PCR purification workflows by offering a range of automation- ready tools for use with magnetic beads and spin columns. These systems reduce hands-on time, improve reproducibility, and free up staff for higher-value tasks.


Magnetic bead-based purification is gaining popularity for its automation potential. Integra’s MAG module enhances this process by automating vertical magnet movements, removing the need to manually transfer tubes and plates to traditional magnetic stands - reducing the risk of spills. The module also concentrates beads into a single, easy-to-aspirate pellet, rather than a ring, helping to ensure cleaner supernatant removal.


For complete walk-away automation, the MAG module integrates with the ASSIST PLUS pipetting robot and Integra electronic multichannel pipettes. This setup offers fully automated PCR purification with minimal intervention and maximum reproducibility. Alternatively, labs can choose semi-automated solutions using VIAFLO 96 or VIAFLO 384 handheld pipettes, allowing simultaneous processing of 96 or 384 samples in high-throughput formats. These workflows are further supported by Integra’s high-yield MAGFLO™ PCR magnetic beads, optimised for amplicon recovery.


Labs using spin column-based protocols can also benefit from Integra’s adaptable pipetting technology. VOYAGER adjustable tip spacing pipettes simplify buffer transfers from reservoirs to columns or silica membrane plates, eliminating the need for time-consuming single-channel work. For even greater time savings, the VIAFLO 96 and VIAFLO 384 enable parallel pipetting across full 96-well plates.


More information online: ilmt.co/PL/Mwlx 64664pr@reply-direct.com Fast, automated plasmid DNA isolation for small-scale research


Thermo Fisher Scientific has introduced the Applied Biosystems™ MagMAX™ Pro HT NoSpin Plasmid MiniPrep Kit to meet the growing need for fast, automated plasmid DNA isolation. Designed for small-scale experiments, the kit enables researchers to quickly and affordably isolate high-quality plasmid DNA, essential for therapeutic research into infectious diseases, cancer, and genetic disorders.


The MagMAX Pro HT NoSpin Kit is among the fastest plasmid purification systems available. Using just 1 millilitre of fresh culture, it allows 96 minipreps to be completed in under 35 minutes - including setup - on a Thermo Scientific™ KingFisher™ instrument. Its automation-ready design supports effortless scaling from benchtop workflows to high-throughput operations.


This kit removes time-consuming manual steps such as cell pelleting and offline lysis, which usually require repetitive centrifugation or filtration, streamlining the purification process and increasing lab efficiency. It uses advanced magnetic bead technology and eco-friendly chemistry to reduce reagent waste and lower operational costs, making plasmid isolation accessible to more laboratories.


“Labs of all sizes need solutions that speed research and eliminate bottlenecks,” said Kevin Lowitz, VP of Sample Preparation at Thermo Fisher Scientific. “By automating plasmid purification and using minimal culture volumes, scientists can run more experiments efficiently, save time and resources, and accelerate their projects.”


For larger volume needs, Thermo Fisher offers the KingFisher™ PlasmidPro Maxi Processor, a fully automated system that processes 150 mL bacterial culture in 75 minutes to yield transfection-grade plasmid DNA with over 80% supercoiled form - without centrifugation or manual steps.


The MagMAX Pro HT NoSpin Kit suits biotech, pharma, CROs, CDMOs, and academic labs requiring high-quality plasmid DNA for early-stage therapeutic and vaccine research. It delivers up to 20 µg of high-copy plasmid DNA per 1 mL culture, compatible with sensitive cell lines and a wide range of downstream applications such as cloning, sequencing, and transfection.


More information online: ilmt.co/PL/xolA 64801pr@reply-direct.com


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