6 HPLC qualification kits for optimal laboratory efficiency


MicroSolv proudly announces the rebrand of its revolutionary HPLC Qualification Kits (PQ Kits), meticulously designed to enhance the qualification process for High-Performance Liquid Chromatography (HPLC) systems. These state-of-the-art kits empower laboratories to maintain compliance with USP<1058> standards while achieving unparalleled accuracy and precision of their HPLC instruments.


The PQ Kits comprise a suite of NIST-traceable calibration solutions, a certified test column, and a validated Excel template for seamless result compilation and graphing. Designed for DIY testing, save time and reduce costs associated with vendor qualifications. Accessory kits are also available for laboratories using fluorescence or refractive index detectors.


The PQ Kits offer a comprehensive solution for ensuring laboratory efficiency and regulatory compliance. Each kit includes NIST-traceable calibration solutions with a Certificate of Analysis (CoA), providing confidence in measurement accuracy. Pre-validated test columns help maintain scientific integrity, while a validated Excel template simplifies result compilation and analysis. Comprehensive test protocols ensure seamless integration into existing SOPs, supporting consistent and reliable workflows. Additionally, laboratories benefit from unlimited technical and educational support, ensuring smooth implementation and ongoing assistance.


The PQ Kits are available for immediate purchase and come with a two-year expiration date from the date of manufacture. Designed for prompt and frequent use, these kits ensure that laboratories can maintain a qualified state for their HPLC systems.


For further details about the PQ Kits or to place an order, visit the HPLC Qualification Kits page, explore the full range of products, or contact the customer service team.


More information online: ilmt.co/PL/ploo and ilmt.co/PL/x5x1 64166pr@reply-direct.com


Study highlights importance of real-time flow rate monitoring in GPC/SEC


Best in class high-pressure stainless steel tubing


MicroSolv’s High-Pressure Stainless Steel Tubing is meticulously crafted to meet the demanding needs of high-pressure liquid chromatography (HPLC) and various other laboratory applications. By ensuring the highest standards in their tubing, MicroSolv enables scientists to achieve unparalleled accuracy and reproducibility in their analytical results.


Manufactured from high-grade stainless steel, this tubing is engineered to withstand the rigors of high-pressure environments. It boasts an exceptional internal surface finish, which minimises potential sites for sample adsorption and carryover. The smooth bore of the tubing enhances flow characteristics, reducing turbulence and ensuring efficient separation.


This high-pressure tubing is designed to be chemically inert, offering excellent resistance to a wide range of solvents and chemicals commonly used in HPLC and UHPLC. Additionally, the tubing can be used with any HPLC instrument and in various other laboratory applications, making it a versatile choice for researchers and scientists. This robustness extends the lifespan of the tubing, providing a cost-effective solution for laboratories striving for optimal performance and reduced maintenance.


A new technical study from Testa Analytical underscores the critical role of continuous flow rate monitoring in Gel Permeation Chromatography (GPC) and Size Exclusion Chromatography (SEC) experiments. Flow rate is a key parameter in liquid chromatography systems, influencing retention times and, ultimately, the reproducibility of results. This study showcases the Testa Analytical Liquid Chromatography Flowmeter as an invaluable tool for non-invasive, real-time flow rate measurement in GPC/ SEC systems.


GPC and SEC are widely used for characterising both natural and synthetic polymers due to their straightforward design. These systems rely on a pump to drive solvent through the column, where the test sample is introduced. The resulting data is analysed using a calibration curve derived from reference standards with known molecular weight. The molecular weight of an unknown sample is determined based on its elution volume, which is matched to the corresponding value on the curve.


In the study, researchers examined the impact of a +/- 1% deviation in flow rate on the molecular weight determination of an unknown sample. This small variation, often caused by backpressure in typical GPC/ SEC systems, is usually undetectable with onboard pump pressure transducers. The experiment involved running a sample after calibration, manually adjusting the flow rate, and repeating the process for a second sample using a viscosity detector and universal calibration.


Results showed that a 1% deviation in flow rate caused more than a 20% change in the calculated molecular weight. These findings highlight the importance of constant flow rate monitoring and the need to adjust chromatogram calculations accordingly.


Testa Analytical’s HPLC Flowmeter provides a solution for this challenge. It offers continuous, non-invasive flow rate monitoring, compatible with various solvents. The device, powered by a USB connection, features a high-resolution thermal flow sensor for precise measurements across a wide dynamic range. An intuitive PC-based app allows users to record and store flow rate data, with real-time data displayed on a built-in OLED screen.


For a copy of the full technical study, contact Testa Analytical.


More information online: ilmt.co/PL/LxXO 64199pr@reply-direct.com


Currently, MicroSolv has most tubing sizes in stock. This ensures that laboratories can access the necessary components without delay, supporting seamless workflow continuity. Moreover, MicroSolv maintains its price levels at rates set before tariffs were imposed on stainless steel. This pricing strategy offers significant cost savings to researchers and institutions, enabling them to acquire top-quality materials without the financial strain.


For further details about MicroSolv’s High Pressure Stainless Steel tubing or to place an order, visit the High Pressure - SS Tubing page, explore the full range of products, or contact the customer service team.


More information online: ilmt.co/PL/J4pB and ilmt.co/PL/dYQ9 64164pr@reply-direct.com Nanoscale degasser and micro flowmeter


Biotech Fluidics reports how its ultra-low volume degassers and non-invasive micro flowmeter are vital lab tools for nanoscale applications including chromatographic separations, dispensing, diagnostics, drug screening, nucleic acid sequencing and tissue culture.


Studying liquid phenomena at a nanoscale level can be very demanding and requires a device designed to continuously monitor ultra-low fluidic flows in real-time. The Biotech Micro Flow Meter is a high-resolution thermal flow sensor that is extremely accurate and sensitive. This reliable flow sensor is compatible with almost any solvent and being non-invasive guarantees the unperturbed operation of your whole nanofluidic system.


Optimised to operate over the 10nl to 80 µL/minute flow range, with an unmatched high resolution of 1nl / minute, the Biotech Micro Flow Meter is the perfect tool for continuously monitoring the consistency of nanoscale dispensing systems as well as uHPLC and LC/MS solvent / reagent delivery systems. Compact in size, the Micro Flow Meter comes with easy-to-use software app enabling continuous recording, monitoring, and storage of measured flow rate data.


A single gas microbubble in a nanoscale liquid dispenser or pumping system can ruin your operational precision and accuracy. Removing dissolved gases from liquids prior to operation is therefore vital to


eliminating the risk of having microbubbles in the fluidic channels. Biotech Fluidics DEGASi®


PLUS Nano and DEGASi® PLUS ultraNano inline degassers are designed to address the challenge of nanofluidic systems by minimising the hold-up volume and offering wide chemical compatibility.


Both the Nano and Nano-Ultra degassers are based on Systec AF membrane making them suitable for water-based media and most organic liquids. The liquid flow path is metal free making these degassers also fully biocompatible. With an internal volume of only 25µl, the DEGASi® hold-up volume of just 6uL the DEGASi®


PLUS Nano is designed for degassing fluid flows up to 100 µl /minute. With a PLUS ultraNano is optimised for extremely low flow applications up to 25 µl /minute. Both


degassers are available with up to 6-channels of operation and are available as standalone or integrated devices. More information online: ilmt.co/PL/OkXX and ilmt.co/PL/LLkJ


63503pr@reply-direct.com


INTERNATIONAL LABMATE - APRIL 2025


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