50 Super-resolution microscope for single-molecule research
ONI has launched the Aplo Scope, a single-molecule super-resolution microscope designed to capture and analyse molecular interactions with unmatched precision. This advanced system enables researchers to explore nanoscale biological structures in real-time, overcoming limitations of traditional imaging techniques.
The Aplo Scope provides a seamless transition from low-power live-cell imaging to high-resolution microscopy at 20 nm resolution, eliminating the need for complex hardware adjustments. Its compact benchtop design integrates cutting-edge imaging technology with automated workflows, allowing scientists to investigate cellular structures in depth and accelerate discoveries in drug delivery, biomarker identification, and antibody therapeutics.
“The future of biology and drug development depends on our ability to visualise molecular interactions with extraordinary clarity,” said Paul Scagnetti, CEO of ONI. “The Aplo Scope delivers the precision and speed required to unlock new insights, pushing the boundaries of what’s possible in medicine.”
Equipped with a custom-engineered laser module offering precise power control (0.01 kW/cm² to 4.0 kW/cm²), the Aplo Scope enables effortless shifts between live-cell imaging and super-resolution at the click of a button. Its advanced filter set and intuitive software simplify complex assays such as multi-colour imaging and time-lapse studies of biological
processes.Researchers worldwide recognise the impact of single-molecule localisation microscopy (SMLM) in understanding disease mechanisms, improving drug discovery, and advancing patient stratification. “This technology has transformed our approach to biomedical research, revealing insights that were previously inaccessible,” said Lorenzo Albertazzi, Associate Professor at TU/e’s Department of Biomedical Engineering.
ONI designed the Aplo Scope as part of the Aplo Platform - an integrated solution combining application-specific kits and cloud-based software. By streamlining workflows and enhancing data analysis, ONI continues its mission to make super-resolution microscopy both powerful and accessible, helping scientists uncover the molecular foundations of health and disease.
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ilmt.co/PL/6LVY 64102pr@reply-direct.com High-speed, automated inverted microscope system
Evident has launched the IXplore™ IX85, an advanced automated inverted microscope system designed to accelerate research workflows with unmatched speed, clarity, and precision. Featuring an industry-leading 26.5 mm field number (FN) and advanced imaging tools, the system enables researchers to capture more data with greater accuracy while streamlining analysis.
The IXplore IX85 delivers consistent lighting across the entire field of view, ensuring high-quality, uniform images. Proprietary distortion correction technology and expanded flatness provide accurate sample representation, even at the edges. Intelligent Shading Correction further enhances image quality by enabling seamless, high-resolution stitched images.
A breakthrough in objective usability, the system introduces a new silicone gel pad that moves with the objective, eliminating the need for frequent oil replacement and reducing maintenance.
“With an expansive field of view and advanced imaging capabilities, the IXplore IX85 enables researchers to uncover new insights faster than ever,” said Motoki Inoue, Vice President of Product Management and Marketing, Life Science Research. “Users can cover larger areas with fewer images, capture more data points per image, and significantly reduce stitching time - cutting the number of required images by up to 50% compared to previous models.”
Designed to enhance lab efficiency, the IXplore IX85 integrates automated acquisition features, real-time image processing, and customisable workflow interfaces. A new automatic correction collar optimises image quality by fine-tuning objectives to reduce spherical aberrations caused by sample variations.
“The system’s modular design ensures long-term adaptability,” Inoue added. “With dual built-in ports for multimodal setups and an open-frame architecture, researchers can easily customise and expand their system to meet evolving needs.”
Additional upgrades include environmental control and advanced imaging modalities such as Spinning Disk Confocal, Super Resolution, Total Internal Reflection Fluorescence (TIRF), and Photomanipulation.
By delivering faster acquisition times and unparalleled imaging performance, the IXplore IX85 supports a wide range of research applications, empowering laboratories of all sizes to stay at the cutting edge of scientific discovery.
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ilmt.co/PL/bjkY New integrated multimodal analytical (S)TEM for advanced materials science research
Thermo Fisher Scientific Inc introduced the Thermo Scientific™ Iliad™ (Scanning) Transmission Electron Microscope (S)TEM at the European Microscopy Congress 2024 in Copenhagen, Denmark. This groundbreaking multimodal analytical solution provides researchers with unprecedented insights into the chemical nature of advanced materials at the atomic level. Utilising Thermo Fisher’s legacy of innovation, the Iliad (S)TEM seamlessly integrates multiple technologies into a user-friendly workflow.
“A platform like this only comes around once in a decade,” said David Wall, Vice President and General Manager of Materials Science at Thermo Fisher Scientific. “Since its unveiling at EMC, Iliad has received enthusiastic responses from researchers and industry leaders worldwide, marking the beginning of a new era in integrated microscopy technology.”
The Iliad (S)TEM features the new Thermo Fisher Scientific EELS Spectrometer and Energy Filter, along with the NanoPulser, an electrostatic beam blanker that optimises electron dosing. This integration of energy dispersive spectroscopy (EDS), EELS, and NanoPulser provides precise chemical and structural investigations of a wide range of modern materials.
Controlled by the Thermo Scientific Velox software ecosystem, Iliad enables even the most challenging experiments to be accessible for every user. Nearly all components can be accessed via Python scripting using Autoscript, allowing advanced control and AI-driven data collection strategies, ensuring reliable workflows.
Professor Jo Verbeeck, co-leader of Electron Microscopy for Materials Science at the University of Antwerp, collaborated on Iliad’s development with a focus on data quantification. “It’s exciting to see ideas on EELS quantification implemented in a product that enhances user experience and reproducibility,” said Professor Verbeeck.
With Iliad, Thermo Fisher Scientific is setting a new standard for advanced analytical (S)TEM technology, empowering scientists to tackle critical challenges and contribute to a healthier, cleaner, and safer world.
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ilmt.co/PL/Vq6R 63486pr@reply-direct.com
63796pr@reply-direct.com
New FIB-SEM enhances automated TEM sample prep
The Crossbeam 550 Samplefab from Zeiss is a focused ion beam scanning electron microscope (FIB-SEM), designed for automated transmission electron microscopy (TEM) sample preparation. Engineered for speed and reliability in semiconductor research, the system streamlines bulk milling, lift-out, and thinning, ensuring high precision and efficiency. With automation yields exceeding 90%, the Crossbeam 550 Samplefab minimises operator intervention while maximising lamella success rates.
TEM analysis plays a critical role in semiconductor device characterisation and process optimisation, but the accuracy and consistency of results depend on high-quality lamellae. The Crossbeam 550 Samplefab addresses this challenge with advanced automation that reduces manual workload and enhances throughput.
The system incorporates the Gemini 2 electron column, enabling real-time SEM observation during FIB milling. This feature ensures optimal lamella quality and precise endpointing, particularly for applications requiring ultrathin samples beyond standard automated processes.
“Our FIB column delivers outstanding stability, reducing the need for frequent calibration or realignment. Many users report weeks of uninterrupted operation, even in high-throughput environments,” Rodgers added. “The system’s robust workflow allows dozens of lamellae to be created using a single probe tip, which requires reshaping only after extended use. A quick reshaping procedure restores tip performance in under 30 minutes, and complete tip exchanges take just half an hour - maximising uptime and lowering operational costs.”
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ilmt.co/PL/Xx44 64103pr@reply-direct.com
INTERNATIONAL LABMATE - APRIL 2025
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