Drug Discovery, Pharmaceuticals & Cannabis Testing
The measured serum exhibited a slight yellow tint in its initial state. Despite the yellow matrix and presence of additional antioxidants, signifi cant colour changes were detected, allowing for a clear observation of degradation at each measurement point (Figure 7). This demonstrated the ability to effectively track vitamin C degradation over time, even in a complex serum matrix.
Figure 9: Monitoring parameters for vitamin C sample variability in production and over a product’s lifetime.
integration, AP Connect enhances effi ciency, compliance, and data integrity across laboratory workfl ows.
Figure 8: Mean value ± standard deviation of OR over time as a result of the L-ascorbic acid degradation in the vitamin C serum (n=3).
Once a target range for the measured parameters is established, the multiparameter measurement system can effectively detect potential degradation. By determining the correlation between the measured quantities and the extent of degradation, the level of degradation can also be monitored.
Summary
The multiparameter measurement system provides an automated and highly precise approach to quality control for multicomponent samples, leveraging interconnected high-precision measurement modules. By analysing samples of known good quality, users can defi ne acceptance ranges for each quality attribute, ensuring consistency and reliability. The selection of modules depends on the specifi c characteristics of the sample being analysed.
The DMA and Abbemat modules are essential for monitoring composition changes, as both density and refractive index (RI) are composition-dependent. The MCP module is specifi cally designed for measuring optically active substances, while a colorimeter is used for colourful compounds or when coloured degradation products may be present. Additionally, the Xsample 530 automates the fi lling and cleaning process, ensuring independent, consistent, and fully automated measurements without manual intervention.
To complement this high-precision measurement setup, AP Connect provides automated data management, ensuring all results are securely stored, easily accessible, and traceable. By eliminating manual transcription and enabling seamless data
Figure 9 summarises the range of key parameters the selected multiparameter measurement system can monitor, enabling the detection of variations during production and throughout the shelf life of vitamin C-containing samples.
References
1. Garre, A., et al. Antiaging effects of a novel facial serum containing L-Ascorbic acid, proteoglycans, and proteoglycan-stimulating tripeptide: ex vivo skin explant studies and in vivo clinical studies in women: Clinical, cosmetic and investigational dermatology, 2018. pp. 253-263
2. Neves, J. R., et al. Effi cacy of a topical serum containing L‐ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs: Journal of Cosmetic Dermatology, 2022. pp. 4462-4469
3. Boo, Y. C. Ascorbic acid (vitamin C) as a cosmeceutical to increase dermal collagen for skin antiaging purposes: emerging combination therapies: Antioxidants, 2022. p. 1663
4. J. Agric. Degradation of Ascorbic Acid in Aqueous Solution: Food Chem. 1998. pp. 5078–5082
5. ICH Q1A (R2) Stability testing of new drug substances and drug products - Scientifi c guideline (Last updated: 01.08.2003)
6. C63IA012EN-A (Vitamin C)
https://www.anton-paar.com/corp-en/services-support/ document-fi nder/application-reports/quality-control-and-stability-monitoring-of-vitamin-c- containing-cosmetic-serums/
Ready-to-use hiPSC-derived cells streamline lab workfl ows
AMSBIO has introduced a new range of fully differentiated human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes, hepatocytes, and neurons, designed to streamline laboratory workflows. These ready-to-use cells eliminate the need for in-house differentiation, significantly reducing preparation time and enhancing research efficiency.
With functional validation performed prior to delivery, researchers can confidently incorporate these cells into their assays without additional optimisation. This is particularly beneficial for Contract Research Organizations (CROs) and life science laboratories, enabling them to save both time and costs associated with validation processes.
AMSBIO’s hiPSC-derived cells offer exceptional batch-to-batch consistency, ensuring reliable experimental outcomes. By providing a physiologically relevant alternative to primary cells and animal models, these cells support a wide range of applications, including drug discovery, disease modelling, and toxicity screening.
More information online:
ilmt.co/PL/Ql1x 64069pr@reply-direct.com
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56
