The latest Business updates from the science industry
SNAP decision paves the way for cutting-edge nano-analysis by Gwyneth Astles
A groundbreaking new research facility at the University of Glasgow is set to transform our understanding of materials at the atomic level, with implications for everything from space exploration to advanced quantum technologies.
A £5.3 million grant from UK Research and Innovation’s Engineering and Physical Sciences Research Council (EPSRC) will fund the development of the Space Nanomaterials Atom Probe (SNAP), the fi rst atom probe tomography (APT) facility in Scotland and one of only six in the UK. The cutting-edge lab will be the only one in the world dedicated to tackling materials challenges in space science.
Atom probe tomography is a state-of-the-art technique that allows researchers to analyse materials atom by atom. Using an ultra- precise laser, individual atoms are extracted from a sample and examined to build a detailed 3D atomic-scale model. This level of insight is crucial for designing materials that can withstand the extreme conditions of space - vacuum, temperature fl uctuations, and high radiation exposure.
Once operational in 2028, SNAP will play a vital role in developing next- generation materials for satellites, spacecraft, and lunar habitats. Beyond space applications, it will also be instrumental in advancing materials research for the semiconductor, quantum, and energy sectors.
Dr Luke Daly from the University of Glasgow’s School of Geographical & Earth Sciences led the funding bid and will oversee the project. He said: “Atom probe tomography gives us an unparalleled view of how materials behave at the smallest scales. With SNAP, we can develop stronger, more resilient materials for space missions while also pushing the boundaries of research in other high-tech industries.”
Dr Paul Bagot from the University of Oxford, a co-investigator on the project, added: “This facility is a huge step forward, not just for Glasgow but for the wider UK research community. It will allow us to delve deeper into atomic-level changes that impact material performance across a range of disciplines.”
Professor Eric Yeatman, Vice Principal and Head of the College of Science & Engineering, emphasised the strategic importance of SNAP: “This new facility cements the University of Glasgow’s position as a leader in advanced materials research. It adds to our expanding suite of high-tech analysis and fabrication capabilities, ensuring we remain at the forefront of scientifi c innovation.”
The SNAP facility will also build on Glasgow’s existing expertise in planetary science. Dr Daly has previously used atom probe tomography to analyse fragments of ancient asteroids, shedding light on the origins of Earth’s water. Now, this cutting-edge
Dr Luke Daly
technique will support future space missions and pave the way for new technological breakthroughs.
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Scientists unveil breakthrough in nano- delivery technology for DNA vaccines
A collaborative effort between The Wistar Institute, University of Pennsylvania, and INOVIO Pharmaceuticals has led to an exciting leap forward in vaccine technology. A team of researchers has demonstrated pre-clinical proof of concept for a revolutionary DNA vaccine delivery system that harnesses the power of lipid nanoparticles (LNPs). This cutting-edge method could change the landscape of immunisation by improving vaccine stability and effi cacy, offering new avenues for combating diseases such as infl uenza and COVID-19.
At the forefront of this groundbreaking research is Dr David B. Weiner, a pioneer in DNA vaccines, whose laboratory at The Wistar Institute worked alongside scientists from the University of Pennsylvania’s Perelman School of Medicine and INOVIO. Their fi ndings [1], published in Cell Reports Medicine, introduce a novel approach that combines plasmid DNA with lipid nanoparticles, providing a more stable and effi cient way to deliver genetic material to immune cells.
In traditional vaccine formulations, DNA has faced challenges related to its stability and size, making it diffi cult to deliver effectively using lipid-based nanoparticles. However, the research team, led by doctoral student Nicholas Tursi, tackled these issues by modifying lipid-based formulations to stabilise the DNA, enhancing its delivery potential. Unlike RNA vaccines, which have been widely studied, DNA’s double-stranded nature and larger size make it a harder candidate for lipid-based formulations. This study marks a signifi cant breakthrough in overcoming these obstacles.
The team used a model DNA-LNP formulation expressing the influenza hemagglutinin (HA) protein to test the new technology. By adjusting the balance between the lipid nanoparticles and DNA, they were able to produce smaller, more stable particles that generated stronger immune responses. The DNA-LNP approach also displayed unique immunological effects, priming both innate and adaptive immune responses in ways that traditional vaccines do not.
RMS Light Microscopy and Confocal Courses 2025
9 – 12 June 2025 | University of York, UK Dr David B. Weiner.
In pre-clinical tests, the new DNA-LNP vaccines triggered robust antibody and T-cell responses after a single dose. These immune responses were not only strong but also long-lasting, persisting for over a year in small animal models. The research also demonstrated the potential of these vaccines to provide protection against SARS- CoV-2, with a single immunisation preventing both morbidity and mortality in a live challenge model.
This study showcases the immense potential of DNA-LNP vaccines as a new platform technology for immunisation. By offering enhanced stability and the ability to provoke strong immune responses, this innovative approach could complement or even replace existing vaccine modalities, especially for diseases that require long-lasting immunity.
More information online:
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1. Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity from Cell Reports Medicine
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The Royal Microscopical Society (RMS) is hosting two hands-on courses at the University of York in June 2025. The
Light covers fundamental principles and practical
Microscopy Summer School (9–10 June) issues
in
light microscopy, suitable for both beginners and more experienced users. Participants will gain valuable hands- on experience through practical sessions, with excellent feedback from past attendees.
Following this, the Getting the Most from Your Confocal Course (11–12 June) delves into confocal microscopy techniques,
including multicolour imaging, FRAP, and
spectral profi ling, focusing on real-world applications and problem-solving with various sample types and fl uorescent probes.
Both courses offer in-depth training for those in research and commercial sectors, with participants leaving equipped with enhanced skills and knowledge.
More information online:
ilmt.co/PL/jm8q 64417pr@reply-direct.com
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