Microscopy & Microtechniques 51 Advanced infrared imaging microscope for pharma and life science applications
Bruker Corporation has introduced the LUMOS™ II ILIM, a quantum cascade laser (QCL)-based infrared imaging microscope that sets new benchmarks in speed and resolution. Designed to meet the needs of pharmaceutical and life science researchers, the LUMOS II ILIM enables ultrafast infrared imaging of large sample areas with exceptional spatial detail.
The microscope incorporates a patented coherence reduction technology that minimises artifacts in both transmission and refl ection modes, delivering artifact-free infrared laser imaging. With a large fi eld of view and full automation, it facilitates rapid analysis of complex biological tissues.
Dr Guillaume Mabilleau, Clinical Bone Pathologist at Centre Hospitalier Universitaire Angers, France, commented: “The speed and quality of infrared imaging provided by this microscope are remarkable. Its ease of use and high throughput, powered by QCL technology, mark a signifi cant advancement in clinical research. We are excited about the potential applications in improving the diagnosis and treatment of bone diseases.”
The LUMOS II ILIM leverages AI-driven data evaluation to advance research in pharmaceuticals, life sciences, and disease studies. Its integration with Bruker’s MALDI Imaging technology enables multimodal tissue characterisation with deeper analytical insights. Additionally, the system is well-suited for pharmaceutical tablet inspection and particle identifi cation, offering automated sampling capabilities.
For added fl exibility, the LUMOS II ILIM includes a Python interface, allowing users to customise workfl ows to meet specifi c research needs. More information online:
ilmt.co/PL/lKGD
New software update enhances Raman and correlative microscopy
Oxford Instruments has announced a major update to its operating software for Raman and correlative microscopes. The latest version, WITec Suite SEVEN, introduces DataTrace, an Enhanced Project Manager, Spectral Certifi cation, and Advanced Cosmic Ray Removal, expanding the platform’s capabilities for measurement control and data analysis.
DataTrace provides comprehensive tracking of measurement settings and data processing steps, including algorithm parameters, data derivation records, and user activity with timestamps. A meta info viewer offers a complete history of experiments, enabling easy searches and parameter exports. These features enhance experiment repeatability and data reproducibility.
The Enhanced Project Manager introduces a redesigned data object window with a new toolbar for quick search, a color-coded hierarchical display, and options to selectively hide objects. This streamlined interface simplifi es complex investigations and improves workfl ow effi ciency.
Spectral Certifi cation ensures system calibration accuracy by comparing spectra against standardised reference samples. Certifi ed spectra are clearly labelled within the software, facilitating work in multi-user facilities and regulatory environments.
Advanced Cosmic Ray Removal eliminates artifacts caused by high-energy particles hitting the detector. It effectively removes multiple cosmic rays, wide artifacts, and those interfering with Raman peaks, making it ideal for long acquisition times and high-precision measurements.
With these enhancements, WITec Suite SEVEN delivers a more transparent, intuitive, and precise software environment. Researchers can now achieve optimal performance from their microscopes and gain deeper insights from their data.
More information online:
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Advancing 3D spatial analysis with high-multiplex imaging
Leica Microsystems, a leader in microscopy and scientifi c instrumentation, has introduced SpectraPlex, a 3D high-multiplex solution designed for spatial discoveries on the STELLARIS confocal platform. This innovation sets a new standard for 3D spatial phenotyping in life sciences.
Omics techniques - Genomics, Transcriptomics, Proteomics, and Metabolomics - have become central to life science research, enabling a deeper understanding of the spatiotemporal relationships between biological components in both healthy and diseased states.
“SpectraPlex was developed to enable researchers to capture more spatially resolved 3D data when studying complex disease states, offering insights into pathological conditions,” said James O’Brien, Vice President of Life Sciences and Applied Solutions at Leica Microsystems. “This solution can help uncover new cell types, identify cellular states, and map functional relationships in a 3D spatial context, advancing our understanding of disease progression and aiding in the identifi cation of therapeutic targets.”
SpectraPlex features a fully integrated workfl ow that allows scientists to capture detailed 3D data at the right resolution with more than 15 markers in a single experiment, far exceeding traditional multicolor imaging capabilities. Additionally, SpectraPlex offers an offl ine tool to design experiments and explore optimal dye combinations for high-multiplex imaging. Users can defi ne a panel, triggering real-time calculations to suggest microscope settings that maximise the signal-to-noise ratio while minimising crosstalk. Experienced users can adjust settings to account for sample-specifi c variances.
In SpectraPlex, unmixed data and raw images are automatically generated to streamline further analysis. Tailored segmentation and downstream analysis powered by Aivia - Leica Microsystems’ AI image analysis software - ensure accurate interpretation of high-resolution, 3D data for over 15 labels.
More information online:
ilmt.co/PL/8972 64104pr@reply-direct.com
New spatial imaging system advances tissue proteomics research
Thermo Fisher Scientifi c has launched the Invitrogen™ EVOS™ S1000 Spatial Imaging System, designed to help researchers generate high-quality multiplexed images while streamlining sample processing.
The EVOS S1000 overcomes key challenges in fl uorescent microscopy by enabling researchers to capture high-resolution images of multiple tissue samples in just hours. Its advanced spectral technology allows simultaneous imaging of up to nine different protein targets, minimising the need for multiple imaging rounds and preserving tissue integrity.
“Understanding tissue structure is essential for advancing treatments for solid tumours and neurodegenerative diseases,” said Trisha Dowling, Vice President and General Manager for fl ow and imaging technologies at Thermo Fisher Scientifi c. “The EVOS S1000 provides a detailed view of tissue microenvironments in their native state, helping researchers accelerate their studies and maximise insights from their samples.”
The system’s compatibility with a wide range of reagents and antibodies ensures seamless integration into existing workfl ows.
“Our lab manages everything from project design to imaging, so delivering high-quality results effi ciently is crucial,” said Carolina Oses Sepúlveda, Researcher and Lab Manager for Spatial Proteomics at SciLifeLab Stockholm. “The EVOS S1000 gives us the fl exibility to use any antibody or reagent - or even work without antibodies - reducing processing time and expanding our research capabilities.”
Now available in the United States and Europe, the EVOS S1000 Spatial Imaging System provides researchers with powerful tools to explore complex biological systems and advance disease research.
More information online:
ilmt.co/PL/MKBx 64033pr@reply-direct.com
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