Mass Spectrometry & Spectroscopy 11 Advancing high-resolution mass spectrometry for proteomics research


SCIEX, a global leader in life science analytical technologies, has enhanced its high-resolution accurate mass spectrometry portfolio with the ZenoTOF 7600+ system, designed to push the boundaries of proteomics research.


The ZenoTOF 7600+ system introduces the advanced ZT Scan DIA strategy, combining the power of the quadrupole dimension with the rich MS/MS data generated by the Zeno trap. This approach simplifies the transition of protein biomarker candidates beyond the discovery phase, addressing a key challenge in proteomics.


According to Jose Castro-Perez, Vice President of Product Management: “This system combines the depth of DIA methods with the specificity of DDA and the precision of targeted approaches to precisely quantify entire proteomes. Our goal is to facilitate researchers in optimising their clinical and translational research workflows, ultimately enabling them to accelerate advancements in precision medicine.”


ZT Scan DIA represents the latest evolution of data-independent acquisition, making the ZenoTOF 7600+ the only system that seamlessly integrates DDA, DIA, and targeted approaches within a single workflow. This unique combination enables the quantification of over 125% more protein groups at sub-nanogram levels compared to conventional discrete- window DIA methods. Electron-activated dissociation (EAD) extends analytical capabilities by enabling tunable fragmentation of all molecule types.


With scanning speeds of up to 640 Hz, the ZenoTOF 7600+ is SCIEX’s fastest accurate mass system, significantly expanding the potential for large-scale quantitation panels. Additionally, the system enhances data analysis by mapping MS/MS scans with the scanning Q1 quadrupole dimension, improving confidence and accuracy in differentiating isomeric peptides and localising post-translational modifications (PTMs).


More information online: ilmt.co/PL/W9Gm A cost-effective FTIR spectroscopy solution


Anton Paar is pleased to announce Lyza 3000, the newest member of its FTIR spectroscopy lineup. Building on the legacy of the well-established Lyza 7000, this streamlined version brings the same reliable optical components, including a cube corner interferometer and DLaTGS detector, to laboratories seeking high performance at a more manageable price.


Unlike its predecessor, Lyza 3000 foregoes a built-in touchscreen, allowing operators to work entirely through Anton Paar’s Spectroscopy Suite on their desktop computers. By doing so, users gain the comfort of a full-size keyboard, mouse, and screen – all of which help simplify navigation and method development. Additionally, this setup makes Lyza 3000 a cost-effective choice without compromising data quality or instrument reliability.


Central to Lyza 3000’s versatility is its modular cell design, inherited directly from Lyza 7000. Whether measuring liquids, solids, or gases, laboratories can swap in the appropriate measurement cell and be ready to go. This adaptability is especially helpful in facilities handling diverse sample types or looking to expand capabilities over time. Since the same cells work seamlessly across both instruments, laboratories can easily share accessories and standardise their workflows.


At the heart of Lyza 3000 is Anton Paar’s Spectroscopy Suite – robust desktop software that keeps every stage of analysis under control. The Spectroscopy Suite includes essential data integrity features needed in highly regulated environments, ensuring traceability from measurement through reporting. Beyond that, it offers integrated control for Anton Paar’s Raman spectrometer Cora 5001, enabling labs to handle both FTIR and Raman measurements in one convenient platform. This unification of software provides a holistic approach to spectroscopy that boosts efficiency and consistency.


Though Lyza 3000 is simpler in appearance, it remains every bit as precise as its bigger sibling. By focusing on core performance and removing extraneous hardware, Anton Paar has achieved a balance that appeals to both experienced spectroscopists and newcomers. With the same robust construction, premium components, and proven track record of analytical excellence, Lyza 3000 delivers consistent results that stand up to the most demanding quality-control requirements.


As a logical extension of Anton Paar’s FTIR portfolio, Lyza 3000 reflects the company’s dedication to advancing accessible, high-quality spectroscopy. By maintaining key performance features in a more economical package, this instrument ensures that laboratories of any size or budget can benefit from proven, reliable FTIR technology.


More information online: ilmt.co/PL/Z62N 64173pr@reply-direct.com


New LCMS-compatible plastic microvials with a permanent marking spot


MicroSolv is excited to announce the launch of its latest innovation in autosampler vials: the LCMS-Compatible Plastic Microvials with a permanent marking spot. These microvials are designed to meet the rigorous demands of modern analytical laboratories.


Each vial features a permanent marking spot, providing clear and lasting identification of samples, essential for accurate tracking and record-keeping.


Manufactured from ultra-pure, virgin, medical-grade polypropylene, the vials are ideal for sensitive applications where high-quality materials are critical to maintaining sample integrity.


The vials are compatible with LCMS applications, as they are free from extractables in most LCMS solvents, ensuring reliable performance in liquid chromatography-mass spectrometry analyses.


Their translucent design allows for easy visual inspection of contents, aiding in sample verification without the need to open the vial.


The flat bottom design enhances needle reach and minimises bubble formation, optimising sample recovery and accuracy during automated processes.


Produced in an ISO 9001:2015 certified facility, the vials meet the highest standards of quality and reliability, offering confidence in their consistent performance across applications.


The LCMS-Compatible plastic microvials are particularly popular for bio-analysis with aqueous samples and samples that react with glass. Their narrow mouth design and 300ul total fill capacity make them an excellent choice for autosampler vials. These vials are available with both a 9 mm thread for screw caps and an 11 mm snap top. Both vials have a 12x32 mm outer dimension.


For further details about the LCMS-Compatible Plastic Microvials, please visit the product webpages 9532S-W-MS & 9532C-W-MS, or contact the customer service team.


More information online: ilmt.co/PL/0ylk and ilmt.co/PL/1ylW 64165pr@reply-direct.com


Precision toroidal mirrors for spectroscopy and imaging


Optical Surfaces Ltd specialises in the production of high-performance toroidal mirrors, ideal for spectroscopic and imaging applications.


Toroidal mirrors feature an aspheric design, where the curvatures of horizontal and vertical axes differ. This unique structure enables toroidal mirrors to combine focusing and beam folding in a single element, making them particularly effective for systems requiring a small, focused spot. Their design enhances energy throughput, promotes compactness, and helps reduce overall costs. In addition, toroidal mirrors mitigate astigmatism, a common issue that arises when spherical mirrors are used off-axis.


With decades of expertise, Optical Surfaces Ltd manufactures toroidal mirrors using materials such as BK7, Zerodur, and fused silica, achieving surface accuracies as fine as λ/10 and surface quality of 10:5 scratch dig. The company’s skilled technicians can produce mirrors in various shapes and sizes, with dimensions reaching up to 500 mm. A wide range of high reflectance coatings is also available to meet specific application needs.


More information online: ilmt.co/PL/bj3n 64348pr@reply-direct.com 63784pr@reply-direct.com


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