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Inspired by temperature
Lipid Nanoparticle Production Equipment for Pharmaceutical Applications
Knauer, the Berlin based manufacturer of high-tech laboratory instruments mostly known for its liquid chromatography systems, also supplies production equipment for pharmaceutical lipid nanoparticles. This development was made possible by combining the company’s expertise in high pressure dosing and in laboratory systems engineering.
New and promising developments in medicine make pharmaceuticals and their active ingredients increasingly complex and bring new challenges. Oligonucleotides, for example, are very susceptible to degradation in the human body. LNPs have shown that they can form a stable basis for the administration of active ingredients like RNA, mRNA, siRNA, or DNA-based APIs. These types of APIs and optimisation of delivery to the target cells are a very vivid fi eld of research.
Knauer’s jet mixing technology has demonstrated outstanding performance for small and large-scale pharmaceutical production of vaccine lipid nanoparticles. The equipment manufacturer supplies small desktop devices to users in research and development as well as complete LNP skids for the pharmaceutical industry. The systems for production, also called IJM skids (impingement jet mixing), are designed and optimised to meet customers’ specifi cations and documentation requirements. System installations in clean rooms (class C) have been successfully carried out. The systems are equipped with all necessary interfaces for the integration into customer’s own PLC (programmable logic controller) systems.
“I am delighted that we have been able to successfully deliver all our systems for vaccine production on time this year. It makes our team proud that we are helping to combat COVID-19 in this way,” said Knauer Business Development Manager, Lilit Avagyan.
Knauer Wissenschaftliche Geräte GmbH is a family-owned company that has been developing high-tech laboratory instruments for research, routine analysis, and production for 58 years. The liquid chromato graphy (HPLC) systems can be used to analyse e. g. food, environmental or drug samples for ingredients or contaminants. The company also produces chromatography systems for the purifi cation of proteins or other valuable substances as well as dosing pumps, valves and detectors for high-pressure applications.
More information online:
ilmt.co/PL/2XLj 53890pr@reply-direct.com
New Remote Live-cell Imaging System Launched
CytoSMART Technologies has announced the launch of a new automated live-cell imaging system designed for long-term experiments, comparison studies, and large laboratory teams. The CytoSMART Multi Lux is a cost-effective solution for researchers who want to carry out side-by-side comparisons between cell cultures, run long-term experiments, and monitor cells from their home’s comfort.
Joffry Maltha, CEO at CytoSMART Technologies, said: “An advanced live-cell imaging system consisting of four mini digital microscopes supported by automated image analysis software is especially useful for research groups that have been negatively impacted by COVID-19 restrictions and want to fi nd new ways to continue their research. No matter how big your laboratory team is, this new Multi Lux technology lets scientists run up to four experiments simultaneously from inside the incubator at perfect culture conditions. Automated image analysis and immediate visualisation of the results are accessible remotely via the CytoSMART Cloud. Besides, researchers who need to culture cells for weeks or even months, can also benefi t from this long-term live-cell imaging solution without fear of needing to throw away cells because of failed experiments.”
The main features and benefi ts of the CytoSMART Multi Lux include: four sample stages for simultaneous side-by-side comparison; long-term non-invasive, label-free image analysis; full remote access: possibility to inspect cell cultures while working from the comfort of home; suitable for large laboratory teams; cost-effective solution: four imaging devices connected to a single laptop, including unlimited storage.
More information online:
ilmt.co/PL/ROnR 53498pr@reply-direct.com
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