Microscopy & Microtechniques 75 New Generation Automated Raman Imaging Microscope Introduced
WITec GmbH establishes the next level of automation and user-friendliness with the introduction of the new alpha300 apyron. Its AutoBeam technology unlocks the full potential of WITec’s industry-leading alpha300 series. The alpha300 apyron’s entirely new optical, analytical and remote operation capabilities mark the furthest advance yet in speed, sensitivity and resolution.
The alpha300 apyron can self-align and self-calibrate, which substantially reduces the researcher’s experimental workload by requiring less user input, enhancing reproducibility and eliminating potential sources of error. This is made possible by a complete set of WITec’s AutoBeam opto-mechanical components, a new and versatile tool kit that can be confi gured to create the perfect experimental setup for every investigation.
New functionalities provided by AutoBeam modules include polarisation-dependent measurements with motorised polariser and analyser rotation, push-button spectrometer connection and signal maximisation, and automated adjustment of both iris diaphragms. Software-driven automation also allows the alpha300 apyron to be operated completely remotely, whether in an environmental enclosure such as a glove box, or from another location.
Available with a wide variety of excitation wavelengths from the ultraviolet through the visible into the near infrared, alpha300 apyron microscopes can be equipped with up to three ultra-high throughput WITec UHTS spectrometers and their accompanying range of detectors. Raman imaging and correlative measurements are defi ned, executed, saved and evaluated with WITec’s Suite FIVE software and intuitive EasyLink handheld controller.
WITec began automating Raman imaging measurements with the fi rst generation apyron. Its advanced technology was introduced to the alpha300 line in stages of spiral development. The new consolidated alpha300 series is a continuous spectrum, from the entry-level access up to the fl agship apyron. They all share the same rock-solid stability, fi bre-based fl exibility and integrated software environment.
The user-friendliness of the alpha300 apyron makes advanced confocal Raman imaging accessible to researchers of all experience levels and fi elds of application. Scientists working in materials science, environmental science and microparticle analysis, life science, food science, geology, pharmaceutics and many other fi elds will benefi t from automated alignment routines that provide consistently optimised performance. The alpha300 apyron accelerates both the experimental setup and subsequent measurement workfl ow.
More information online:
ilmt.co/PL/xQrB 52114pr@reply-direct.com
New Platform Provides a New Dimension of Information to Confocal Imaging
Leica Microsystems has announced the launch of its fl agship new confocal microscopy platform, called STELLARIS. The platform will signifi cantly improve how scientists are able to capture three-dimensional images of living cells and tissues.
STELLARIS gives access to lifetime-based information in every experiment, in parallel with common intensity imaging approaches. Scientists will fi nd that the unique TauSense lifetime-based imaging modes open up the potential to discover more. These modes complement a multitude of new ways to explore the function of molecules in their cellular context and help, for example, separate fl uorophores even when their emissions fully overlap. Another benefi t is that the number of simultaneous detection channels can be expanded by using lifetime-based information. Access to this advanced imaging information takes just one click. The new smart user interface, ImageCompass, ensures that scientists have the productivity to do more, as setting up even complex experiments is now much easier and more intuitive than ever before.
STELLARIS offers signifi cant enhancements compared to existing confocal systems on the market. The enhanced sensitivity in the blue-green range (PDE > 55%) improves the detection limits and dynamic range for the most commonly used fl uorophores. The extension of the detection range to the Near Infrared (NIR) provides up to 67% more dynamic range compared to current state-of-the-art detectors. The NIR extension allows for additional freedom when selecting dyes and up to three additional colours. The new detector generation in combination with the renowned Leica spectral detection technology and a newly designed beam path to maximise transmission effi ciency, enables effi cient signal acquisition while valuable samples are afforded the lowest possible exposure to light. Ultimately, this facilitates ‘gentle’ live cell imaging, preserving sample integrity and improving reproducibility of results.
The integrated TauSense is an innovative set of imaging modes based on fl uorescence lifetime without the need to add extra dedicated hardware. It enables scientists to differentiate between specifi c fl uorescence signals and unwanted autofl uorescence to improve the quality of the fi nal image and separate fl uorophores that could not be previously separated with spectral unmixing.
More information online:
ilmt.co/PL/ROE4 52776pr@reply-direct.com
New UV Ring Light for Stereo Microscopy Launched The new SCHOTT®
VisiLED UV Ring Light for stereo microscopes combines classic bright-fi eld illumination with UV illumination. It is the only
segment ring light on the market in which white-light and UV-LEDs are alternately installed in eight segments. This LED arrangement allows objects to be examined from the same illumination angle, which signifi cantly improves the ability to compare and reproduce resulting images. While the homogenous white light displays samples in natural colour, UV excitation reveals previously invisible parts of the sample through fl uorescence. The SCHOTT MC 1100 Controller (available for separate purchase) makes it easy to switch between the two illumination modes.
The UV Ring Light for stereo microscopes is used in applications such as forensic document examination, crack detection or examination of paints and varnishes. With fl uorescent markers and UV light, previously invisible details can be made visible. A UV protection fi lter in the observation path ensures that the user can look safely at the sample through the eyepieces and clean operation of the microscope camera.
“We were increasingly asked by customers for UV illumination that is safe and easy to use,” said Dr Christian Zawar, Senior Sales Manager at SCHOTT Lighting and Imaging. “In addition, the user always needs a normal bright fi eld illumination on the microscope. Our new VisiLED UV ring light combines both of these capabilities in a unique way.”
The VisiLED UV Ring Light contains UV-A LEDs that emit wavelengths between 340 and 420 nm, with a central wavelength of 375 nm. The new UV ring light offers an illuminance of 100 klx in bright-fi eld mode and 160 W/m² in UV-illumination mode. Each ring light comes equipped with the SCHOTT GG435 UV Protection Filter. Although the segment ring light belongs to risk class 3 according to IEC62471, the fi lter ensures maximum safety for the eyes when looking into the eyepieces.
More information online:
ilmt.co/PL/6Pa3 52613pr@reply-direct.com
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