Reagents, Reference Materials & Laboratory Chemicals
New HPLC/UHPLC Methanol for Superior Chromatography Launched
Methanol, the simplest alcohol that exists, is a colourless, low-density, flammable and water-miscible liquid. Methanol and water have similar properties because both have hydroxyl groups that can form hydrogen bonds. These two solvents form hydrogen bonds with each other, being perfectly miscible in all proportions.
The high polarity of methanol makes it a very good solvent for polar substances. These characteristics make it one of the most used solvents in liquid chromatography. In this technique, the absorbance of the mobile phase is one of the critical points in the choice of solvent: the lower the absorption of the solvent, the greater the accuracy of the test and the better results under conditions of gradient elution.
Scharlab launches its new Methanol Ultragradient (ME0339), the only HPLC methanol on the market that ensures minimal gradient absorption at 3 different wavelengths (230, 235 and 254 nm).
This new product, with the most restrictive specifications on the market, allows to carry out the most demanding analyses in the entire wavelength range. After passing an exhaustive Quality Control in their laboratory, Scharlab can ensure that Scharlau’s Methanol Ultragradient is the cleanest solvent with the lowest number of impurities, suitable for any chromatographic analysis. Scharlab’s Methanol Ultragradient is also suitable for UHPLC. More information online:
ilmt.co/PL/Mpox
51437pr@reply-direct.com
Collaboration to Commercialise Specialised MAT Reagents for in vitro Pyrogen Testing Announced
Lonza Sales AG, through its Bioscience Division, and Sanquin Reagents BV have entered into a strategic partnership for the commercialisation of a range of specialised reagents for pyrogen testing of parenteral pharmaceuticals and medical devices using the Monocyte Activation Test (MAT). This partnership expands Lonza’s extensive portfolio of endotoxin testing products, and enables drug developers and quality control (QC) laboratories to explore the full potential of the high-performing, sustainable MAT method to bring safe pharmaceuticals to the market.
Contrary to the conventional Rabbit Pyrogen Test (RPT), which works by measuring temperature changes in rabbits following administration of a test sample, the MAT does not involve the use of experimental animals. As such, it enables QC laboratories to comply with stringent animal welfare regulations and meet their sustainability objectives. Being a highly sensitive in vitro human cell-based assay, the MAT is capable of consistently detecting pyrogenic activity in even the most complex pharmaceuticals, such as vaccines and cell- and antibody-based biologics, where use of the RPT is limited.
Under the new agreement between Lonza and Sanquin, cryopreserved pooled human Peripheral Blood Mononuclear Cells (PBMCs) produced by Sanquin specifically for use with the MAT will bear the Lonza branding. The cells are developed in line with the requirements of the European Pharmacopoeia chapter 2.6.30, following an optimised donor selection, cell isolation and cell quality testing process. Compared to fresh PBMCs, cryopreserved pooled PBMCs eliminate the need to undertake cell isolation for each single test run. As a result, the cells are available on demand whenever a need arises and large number of vials from one batch guarantee a long term test consistency. Lonza will further distribute the Sanquin-branded PeliKine compact ELISA Kits that have been validated for use with the MAT assay. Together with Lonza’s testing hardware, media and accessory offering, drug developers and QC laboratories will now profit from a comprehensive and optimised MAT solution that is in line with regulatory requirements.
52355pr@reply-direct.com
New ATR Mode Certifi ed Polystyrene Reference Films
Starna now supply an ‘ATR’ set of polystyrene film references to assist compliance with the new European Pharmacopoeia Chapter 2.2.24. This is supplied as a kit of two films: a RM-1921/38 film certified film for normal Transmission measurements; and an accompanying film specifically certified for ‘ATR only’.
This new set expands the Starna range of polystyrene film references for use in FTIR, MidIR and NIR Wavelength Calibration to include both Transmission and ATR modes. Existing films are available in two thicknesses: RM-1921/38 is a 38 µm polystyrene film with 14 certified peaks from 540 cm-1 to 3080 cm-1 (18.5 µm to 3.25 µm) whose values are traceable to NIST SRM 1921b. A thicker version, RM-1921/65, is 65 µm thick and in addition to the 14 peaks in the MidIR eight peaks are certified in the NIR from 3060 cm-1 to 8750 cm-1 (3.25 µm to 1.15 µm). These peaks are traceable to NIST SRM 2065.
They comply with the latest revisions of the European Pharmacopoeia Chapter 2.2.24, and US Pharmacopoeia General Chapters 854 and 1854 on Mid-Infrared Spectroscopy. The references are presented as card mounted films in the conventional industry pattern; ATR film unmounted. Easy to use, they simply slip into the standard sample holder of any FTIR instrument. These references are produced under Starna’s ISO 17034 Reference Material Producer accreditation and certified under ISO/IEC 17025 for Calibration.
More information online:
ilmt.co/PL/Z3jV and
ilmt.co/PL/QDkp 51559pr@reply-direct.com
The Spotlight could be on you! Contact Gwyneth Astles on +44 (0)1727 855574 or email:
gwyneth@intlabmate.com
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