Chromatography 15
Glass Autosampler Vials Virtually Eliminate Surface Activity
Reduced Surface Activity (RSA™) glass autosampler vials are not coated vials and virtually eliminate the adsorption of basic compounds found with all other glass vials. The manufacturing process of RSA™ vials produces vials without surface activity such as basic compound adsorption. Unlike ordinary glass vials, these vials will
not produce a pH change with aqueous diluent over time in the vial and with minimised surface
metals, it is excellent for LCMS in that it does not contribute to sodium adducts.
Laboratories testing low abundance analytes such as low dosage form pharmaceuticals, unknown unknowns and natural products will see the greatest benefit even though all labs will find these vials to have value when repeating runs or investigations must be avoided.
The vials are available from Microsolv in 12x32mm clear and amber with volumes of 2ml, 1.5ml and 300ul.
More information online:
ilmt.co/PL/ZJGm 52069pr@reply-direct.com
New High-Performance Liquid Chromatograph to Help Laboratories Meet Quality and Production Targets Introduced
Waters Corporation has introduced the Waters™ Arc™ HPLC System, a new high-performance liquid chromatograph (HPLC) for routine testing in the pharmaceutical, food, academic and materials markets. A key target application is quality control laboratories performing batch release tests on small molecule pharmaceuticals. Waters also announced the availability of Waters™ Empower™ BC LAC/E™ with SecureSync, its newly enhanced data back-up and recovery solution purpose-built for organisations with distributed laboratory environments.
The Arc HPLC System is for laboratories looking for a rugged, reliable and modern HPLC system that can run established HPLC methods regardless of the brand of liquid chromatograph on which they were originally developed, while preserving the chromatographic retention time reproducibility of those methods. The system offers ultra-low analyte carryover, superb injection precision and backpressure tolerance to 9,500 psi at 5.0 ml/min. It is designed to meet all the requirements of a top-of-the-line HPLC system in a cost-competitive package that takes routine testing to the next level.
“We designed the Waters Arc HPLC System exclusively for QC laboratories knowing how important trustworthy test results are to help ensure the uninterrupted supply of safe and effective medicines,” said Robert Buco, PhD, Director, Separations Technology, Global Product Management, Waters Corporation. “Arc HPLC is for customers who are ready to modernise legacy instruments while preserving their specific QC methods. Waters makes it simple, providing a unique two-injection method transfer capability from any brand of HPLC instrument onto the Arc HPLC System.”
“As a Waters customer for many years, we have standardised on Waters instrumentation and Empower software for testing,” said Bo Chen, Instrument Manager, Luoxin Pharmaceutical (Shanghai) Co., Ltd. “Their instrumentation has proven to be reliable and rugged and we know from experience that they stand by their products. The new Arc HPLC System appears to be highly suited for testing of finished products and we are eager to give it a closer look.”
More information online:
ilmt.co/PL/AeDL 52600pr@reply-direct.com
ADVERTORIAL Columns and Supplies from One Source
As a manufacturer of SPE, HPLC and GC columns as well as TLC plates MACHEREY-NAGEL has grown from a pioneer in chromatography to a full-range supplier of laboratory consumables. With short supply chains MN equips laboratories worldwide in about 150 countries via their well-educated distributors. Own subsidiaries in Germany, Switzerland, France and the US ensure high quality support for chromatography users in these countries.
Besides innovative developments of HPLC columns like NUCLEODUR® HR-X and OPTIMA®
or NUCLEOSHELL® GC columns, a broad range of supplies are available.
The portfolio contains autosampler vials and caps for HPLC and GC for all common instrument manufacturers, such as Waters, Agilent, Shimadzu and others. It is completed by lab accessories, like vial containers and racks or crimpers / decappers. Storage vials for liquid or powdery samples are available as well. A new 20 mm crimp closure with Silicone/PTFE liner (Pharma-Fix) sets a new standard in the GC headspace area. This closure is characterised by high analytical purity and high temperature resistance (-60°C up to 200°C), good penetration properties and excellent sealing.
CHROMAFIL® and CHROMAFIL® Xtra syringe filters increase the lifetime of columns and equipment by removal of solid particles. Different membranes
(e.g., PTFE, RC, Nylon) and pore sizes are used for rapid purification of samples. The innovative H-PTFE (hydrophilized polytetrafluoroethylene) membrane is recommended for polar and nonpolar solutions. It is resistant towards all kinds of solvents as well as acids and bases.
The QuEChERS method has gained a leading position for the determination of pesticide residues in food samples. Dispersive SPE products allow rapid extraction and clean up of strongly matrix contaminated samples. MN offers many QuEChERS mixtures for sample preparation in various sizes and amounts of adsorbents according to AOAC Standard 2007.1 and EN 15662.
For handling SPE columns and cartridges the product range includes vacuum manifolds, replacement parts, products for protection from cross contamination, and tubing adapters for application of large sample volumes. Furthermore, empty columns and accessories for individual packing of SPE columns with CHROMABOND®
adsorbents are available.
Various Flash and LC adsorbents for preparative applications in the chemical and pharmaceutical industry are produced by MN. CHROMABOND® Flash cartridges are the solution for automated preparative purification of compound mixtures. Due to the broad product range irregular and spherical silica phases for liquid chromatography (LC) as well as NUCLEODUR®
chromatography (HPLC) can be selected.
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Tel.: +41 62 388 55 00 Fax: +41 62 388 55 05 E-Mail:
sales-ch@mn-net.com
ZERTIFIZIERT
In GC, the volatility of compounds plays a major role. It can be improved with high purity derivatisation reagents from MN (e.g., TMSH, MSTFA, MBTFA). Also a better thermal stability for analytes and a lower limit of detection in gas chromatography applications can be achieved.
www.mn-net.com
H & Co. KG · Neumann-Neander-Str. 6–8 · 52355 Düren · Deutschland CH:
FR: CH: ISO 9001
Tel.: +49 24 21 969-0 Fax: +49 24 21 969-199 E-Mail:
info@mn-net.com
Tel.: +33 388 68 22 68 Fax: +33 388 51 76 88 E-Mail:
sales-fr@mn-net.com
Tel.: +41 62 388 55 00 Fax: +41 62 388 55 05 E-Mail:
sales-ch@mn-net.com
ZERTIFIZIERT
MACHEREY-NAGEL GmbH & Co. KG · Neumann-Neander-Str. 6–8 · 52355 Düren · Deutschland DE / International:
CH:
Tel.: +49 24 21 969-0 Fax: +49 24 21 969-199 E-Mail:
info@mn-net.com
Tel.: +33 388 68 22 68 Fax: +33 388 51 76 88 E-Mail:
sales-fr@mn-net.com
More information online:
www.mn-net.com/chroma
52610pr@reply-direct.com
MACHEREY-NAGEL GmbH & Co. KG · Neumann-Neander-Str. 6–8 · 52355 Düren · Deutschland DE / International: FR:
FR:
Tel.: +41 62 388 55 00 Fax: +41 62 388 55 05 E-Mail:
sales-ch@mn-net.com
Tel.: +33 388 68 22 68 Fax: +33 388 51 76 88 E-Mail:
sales-fr@mn-net.com
www.mn-net.com
www.mn-net.com
www.mn-net.com Your solutions at
www.mn-net.com , modern polymeric SPE phases like CHROMABOND® HLB or
MACHEREY-NAGEL Columns and supplies
adsorbents for high performance liquid
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Chromatography
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