27 Mass Spectroscopy Point-of-Need Mass Spectrometer Launched


Microsaic Systems has announced the launch of its latest chip-based mass spectrometer. Designed for point-of-need analysis, the 4500 MiD® can be installed where contemporary mass spectrometers cannot be deployed, all while retaining the performance of a conventional mass spectrometry (MS) system.


Offering a one box solution for MS detection, Microsaic uses chip-based miniaturisation technology to provide agile sample detection and identification at the point of use. This allows end users to make quick decisions in real-time to optimise overall productivity.


The company’s latest innovation, the 4500 MiD® combines the vacuum system, electronics and computer inside on box, with no need for a floor pump. Reliable, robust and user friendly, the new system boasts an increased mass range, a completely tool-less front-end for enhanced control, and an intuitive user interface. In addition, a change in front-end alignment has also strengthened system uptime while reducing the deposition of contaminants downstream.


Easy to operate and maintain, users don’t require any prior MS knowledge as the 4500 MiD® system is simple to set up and use. It also offers reduced solvent, nitrogen and power consumption to lower operating costs and provide a greener solution for mass detection.


Glenn Tracey, CEO, commented: “Developed from customer feedback and market analysis, the 4500 MiD® opens up even more applications for point-of-need mass spectrometry, including for larger biological molecules, such as peptides and small proteins.


“With over 60 patents to date, we’re committed to further developing miniaturised mass spectrometry to bring the benefits of robust point-of-need analysis to biologics detection. We continue to invest in technologies that will be able to detect a range of biological entities, such as monoclonal antibodies, in just minutes. This will have a significant and very positive impact on biologic manufacturing productivity, and we are working with some of the foremost companies in the field.”


46027pr@reply-direct.com 8691ad@reply-direct.com Evaporative Sample Prep for Mass Spectrometry


Genevac has developed an online bibliography of customer technical articles that illustrates how centrifugal evaporation has become a sample preparation technique of choice for laboratories that seek to analyse complex samples using hyphenated mass spectrometry [MS] techniques.


Many laboratories still rely upon the use of a rotary evaporator to perform the evaporation part of their sample preparation protocol prior to LC-MS or GC-MS analysis. While rotary evaporator methods often give good recoveries, they can only handle a single sample, require continuous monitoring to control the process and to ensure that no foaming or bumping occurs.


For labs involved with GC-MS or LC-MS – Genevac SampleGenie™ technology in conjunction with a Rocket Synergy, HT or EZ-2 series evaporator is enabling large sample volumes to be dried directly into vials eliminating several time-consuming sample handling steps and the attendant risk of errors. SampleGenie is proven to reduce evaporation times by up to 66%, is compatible with a wide range of HPLC, GC and storage vial sizes and is a proven methodology for environmental analysis, metabolism and toxicology studies, food and beverage research, drugs of abuse testing as well as post purification protocols in life science research.


Environmental analysis of persistent organic pollutants (POPs), glyphosphates and agal toxins are today a critical requirement in monitoring the quality of municipal water supplies. A paper is available for download that describes how a direct evaporative method developed to replace a solid phase extraction sample preparation technique that has traditionally been used prior to LC-MS-MS analysis of algal toxins in lake water. The authors demonstrate how the direct evaporation sample preparation technique offers distinct advantages over solid phase extraction by eliminating the sample clean-up step, improving reproducibility, decreasing analysis time, minimising waste generation and being more cost effective.


MALDI-TOF Mass Spectrometry is a widely accepted technique for the elucidation and quantitation of biomolecules in life science research. However concentrating oligonucleotides, proteins, antibodies and other large biomolecules prior to analysis is not straightforward. A paper is available for download that describes how Genevac centrifugal evaporators have been able to protect these sensitive samples from thermal degradation and by preventing cross contamination between different samples in a microplate.


To review and download the ‘Evaporative Sample Preparation for Mass Spectrometry’ papers please visit www.evaporatorinfo.com/info24.html. For further information on centrifugal evaporators please visit www.genevac.com or contact Genevac on +44-1473-240000 / +1-845-255-5000 / salesinfo@genevac.co.uk.


46286pr@reply-direct.com New Ultra-High Mass Range Mass Spectrometer Provides Solutions for Analysis of Proteins and Protein Complexes


The Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap Mass Spectrometer is the first platform from Thermo Fisher Scientific to combine high resolution, high sensitivity, MS2 and pseudo-MS3 capabilities. The new system overcomes previous technology limitations that prevented native mass spectrometry from achieving its full potential and creates a workflow for the structural analysis of proteins and complexes.


“With the level of sensitivity and high resolution of the Q Exactive UHMR platform, researchers can better understand protein structure and interactions,” said Ken Miller, Vice President, Omics Marketing, Chromatography and Mass Spectrometry, Thermo Fisher. “We expect the more detailed structural insights from this new system to enhance our understanding of protein function, disease mechanisms, potential drug targets and biotherapeutic compounds.”


“To unlock a greater understanding of proteins and their interactions, we require substantially increased sensitivity and mass resolution at high m/z,” said Albert Heck, Professor, Biomolecular Mass Spectrometry and Proteomics, University of Utrecht. “This instrument enables high-fidelity, hypothesis-free mass analysis of intact ribosome particles, revealing the substoichiometric association of even elusive small proteins.”


The Q Exactive UHMR mass spectrometer is designed to resolve the small differences in masses required to characterise intact biomolecular assemblies and other large molecular complexes. The new mass spectrometer can verify sample quality prior to analysis by cryo-electron microscopy (cryo-EM) and determine sample composition and homogeneity to enable successful cryo-EM analysis.


Benefits of the new system include: ultra-high resolution and orders of magnitude for great sensitivity, at up to 80,000 m/z, to resolve the small differences in masses needed to characterise intact biomolecular assemblies and complexes; In-source trapping capability that enables improved transmission and controllable desolvation and fragmentation; high mass quadrupole selection and high HCD fragmentation efficiency for better native top-down analysis.


When analysts combine the Q Exactive UHMR mass spectrometer with the integrated Thermo Scientific BioPharma Finder 3.0 Intact software for deconvolution and Thermo Scientific ProSight software, they can elevate their research by confirming intact molecular weight of proteins and complexes as well as by obtaining sequence information and identifying potential modifications.


46492pr@reply-direct.com Mass spectrometers for vacuum, gas, plasma and surface science


Instruments for Advanced Science


QGA Gas Analysis System Fast data acquisition


500 measurements/sec Response time to 150 ms Dynamic range PPB


to 100%


Microreactor with integrated MS detector


TPD/TPR/TPO and reaction studies


1-20°C/min heating rates


Temperature ramps up to 1000°C


Close-coupled hotzone for 500 ms response


W www.HidenAnalytical.com info@hiden.co.uk E


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