MSA 2020 Awards
More recently, Zhuang invented a first-in-kind single-cell
transcriptome-imaging method—multiplexed error-robust fluorescence in situ hybridization (MERFISH)—which took molecular imaging to the genome scale and has revolutionized the field of single-cell genomics. Single-cell
transcriptomic
analyses are critical to understanding the molecular origin of cell behavior and tissue function. Yet, conventional sequencing- based single-cell transcriptomics approaches require dissocia- tion of cells from tissues and extraction of RNAs from cells; therefore, the spatial information of RNAs and cells is lost. Tis loss of spatial information represents a major limitation, as the spatial organization of cells is critical to the develop- ment and function of tissues. Zhuang’s MERFISH method has overcome this major challenge in the field and enabled in situ, spatially resolved, single-cell transcriptomics.
Burton Medal Te Burton Medal honors annually the distinguished con-
tributions to the field of microscopy and microanalysis by a scientist who is less than 40 years of age on January 1st of the award year (that is, the awardee to be honored at M&M 2020 cannot have been born earlier than 1980).
Burton Medal: Brent Nannenga A s a p o s t d o c t o r a l
Brent Nannenga, Assistant Professor of Chemical Engineering, School for Engineering of Matter, Transport and Energy, Arizona State University.
researcher in the laboratory of Tamir Gonen at the Howard Hughes Medical Institute’s Janelia Research Campus, Dr. Nanenga’s research focused on cryo-EM and the devel- opment of a new method in electron diffraction called microcrystal electron diffrac- tion, or MicroED. Since the initial MicroED publication in 2013, it has been used to solve numerous high-resolu- tion structures from very thin microcrystals. During his time
as a postdoctoral researcher, Brent was involved in the publica- tion of 7 papers on MicroED, which were in journals such as Nature, Nature Methods, and eLife. Initially developed using protein microcrystals, MicroED has since been extended to the analysis of peptides and small organic molecules, with many of these being novel structures that were unable to be determined using other structural methods. Tere has been great interest in this technique from the microscopy and structural biology communities, because growing large crystals can be extremely difficult, and new microcrystallography techniques are in high demand. Since starting his own research group at Arizona State
University, Brent has continued to focus on the development and application of electron microscopy methods. One key area of research in his group is extending MicroED sample handling and data collection procedures to microcrystals, which are grown in the viscous lipidic cubic phase, specifically G-protein coupled receptors (GPCRs), which are an important class of membrane proteins that represent approximately 50%
2021 May •
www.microscopy-today.com
James LeBeau, Associate Professor, Department of Materials Science & Engineering, Massachusetts tute of Technology.
Insti-
of all drug targets. In addition to his work on MicroED, Brent is studying the molecular interactions of biological molecules with inorganic materials, using both crystallography and single-particle cryo-EM.
Burton Medal: James LeBeau James LeBeau’s research
is focused on developing fun- damental understanding of material
properties through
imaging and spectroscopy, and he has achieved this through the development of new tech- niques for data acquisition and analysis. His research has transformed the STEM field, expanding the scope of quantitative electron micros- copy in a way that enhances its applications
to real-world
problems. Te techniques Jim has developed and advanced
are being adopted widely across the microscopy and materi- als sciences communities, and they enable new insight into the atomic structure of materials and how structure trans- lates into unique material functionality. Jim’s contributions can be grouped into two classes, although these are, of course, interconnected: developing a suite of new methods in STEM acquisition and analysis and applying these methods to key materials problems. Te development of these methods was driven by Jim’s
interest in solving specific materials problems that could not be addressed using conventional STEM imaging, even at high resolution. Te techniques are especially useful in understand- ing material properties that are influenced by local structure, for example, when local unit cell crystallography has lower symmetry than the averaged structure, or at material surfaces and interfaces. In such cases, the ability to perform quantita- tive STEM analysis using these innovative techniques opens the doorway to understanding nanoscale interactions and the influence of atomic constituents on a range of structurally driven functional properties. Te methods are powerful tools for the analysis of material crystallography, complementing diffraction-based pair distribution function techniques that otherwise require access to national beamline facilities, while also having the benefit of spatial resolution and correlation with local chemistry measurements.
Albert Crewe Award Te Albert Crewe Award was initiated to recognize annu-
ally the distinguished contributions to the field of microscopy and microanalysis in the physical sciences of an early career scientist, of not more than 6 years’ standing since doctoral graduation, for research performed during this period.
Crewe Award: Andrew Yankovich Based on his groundbreaking research, Andy Yankovich is
widely recognized as a leading young scientist in the materials 11
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