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Microsampling – a look back at 2015 Editorial


tigations into the technique and ongoing innovations have led us to the current state of the ‘slope of enlight- enment’, which can be said to be associated with the expansion of microsampling beyond its DBS origins to a wealth of other microsampling techniques and work- flows. This increased understanding and the availabil- ity of a broader variety of tools will hopefully lead the combined microsampling techniques to the ‘plateau of productivity’. In this final state, microsampling will find its exclusive niche, where its advantages over other approaches for the generation of bioanalytical data in certain situations will be generally recognised and, hence, it will be preferentially used in these circum- stances. The agenda for microsampling for quantita-


References


1 Musteata FM. Pharmacokinetic applications of microdevices and microsampling techniques. Bioanalysis 1(1), 171–185 (2009).


2


Spooner N, Denniff P, Michielsen L et al. A device for dried blood microsampling in quantitative bioanalysis: overcoming the issues associated blood hematocrit. Bioanalysis 7(6), 653–659 (2015).


3 Mano Y, Kita K, Kusano K. Hematocrit-independant recovery is a key for bioanalysis using volumetric absorptive microsampling devices, Mitra™. Bioanalysis 7(15), 1821–1829 (2015).


4 Miao Z, Farnham JG, Hanson G, Podoll T, Reid MJ. Bioanalysis of emixustat (ACU-4429) in whole blood collected with volumetric absorptive microsampling by LC- MS/MS. Bioanalysis 7(16), 2071–2083 (2015).


5 6


Luo Y, Korfmacher W, Ho S et al. Evaluation of two blood microsampling approaches for drug discovery PK studies in rats. Bioanalysis 7(18), 2345–2359 (2015).


Parker SL, Roberts JA, Lipman J, Wallis SC. Quantitative bioanalytical validation of fosfomycin in human whole blood with volumetric absorptive microsampling. Bioanalysis 7(19), 2585–2595 (2015).


7 Houbart V, Cobraiville G, Servais AC, Napp A, Merville MP, Fillet M. Hepcidin determination in dried blood by microfluidic LC-MS/MS: comparison of DBS and volumetric absorptive microsampling for matrix effect and recovery. Bioanalysis 7(21), 2789–2799 (2015).


8


Lenk G, Sandkvist S, Pohanka A, Stemme G, Beck O, Roxhed N. A disposable sampling device to collect volume- measured DBS directly from a fingerprick onto DBS paper. Bioanalysis, 7(16), 2085–2094 (2015).


9 Mengerink Y, Mommers J, Qiu J, Mengerink J, Steijger O, Honing M. A new DBS card with spot sizes independent of the hematocrit value of blood. Bioanalysis 7(16), 2095–2104 (2015).


10 Sturm R, Henion J, Abbott R, Wang P. Novel membrane devices and their potential utility in blood sample collection prior to analysis of dried plasma spots. Bioanalysis 7(16), 1987–2002 (2015).


tive bioanalysis will continue to evolve and if history is anything to go by, we will see the developments played out through the pages of Bioanalysis in the coming years. It’s an exciting prospect!


Financial & competing interests disclosure The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or fi- nancial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria,


stock ownership or options, expert testimony,


grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this


manuscript.


11 Boonyasit Y, Laiwattanapaisal W. A microfluidic paper- based analytical device for the assay of albumin-corrected fructosamine values from whole blood samples. Bioanalysis 7(1), 79–90 (2015).


12 Ge S, Zhang L, Yu J. Paper-based microfluidic devices in bioanalysis: how far have we come? Bioanalysis, 7(6), 633–636 (2015).


13 Eijel J. Chip-based capillary electrophoresis platforms: toward point-of-care applications. Bioanalysis, 7(11), 1385–1387 (2015).


14 Donabella PJ, Rogers N, Levin R, Musteata FM. Development of supported liquid-phase microextraction probes for in vivo PK studies. Bioanalysis 7(6), 661–670 (2015).


15 Koster RA, Alffenaar JWC, Botma R et al. What is the right blood hematocrit preparation procedure for standards and quality control samples for dried blood spot analysis? Bioanalysis 7(3), 345–351 (2015).


16 Koster RA, Botma R, Greijdanus B et al. The performance of five different dried blood spot cards for the analysis of six immunosuppressants. Bioanalysis 7(10), 1225–1235 (2015).


17 Koster RA, Alffenaar JWC, Botma R et al. The relation of the number of hydrogen-bond acceptors with recoveries of immunosuppressants in DBS analysis. Bioanalysis 7(14), 1717–1722 (2015).


18 Lenk G, Hansson J, Beck O, Roxhed N. The effect of drying on the homegenity of DBS. Bioanalysis 7(16), 1977–1985 (2015).


19 Korfmacher W, Fitzgerald M, Luo Y et al. Capillary microsampling of whole blood for mouse PK studies: an easy route to serial blood sampling. Bioanalysis 7(4), 449–461 (2015).


20 Takyi-Williams J, Dong X, Gong H et al. Application of paper spray – MS in PK studies using sunitinib and benzethonium as model compounds. Bioanalysis 7(4), 413–423 (2015).


21 Abu-Rabie P, Spooner N, Chowdhry BZ, Pullen F. DBS direct elution: optimising performance in high-throughput quantitative LC-MS/MS analysis. Bioanalysis 7(16), 2003–2018 (2015).


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