PRIME PRoMotIon |
At each follow-up visit, the independent doctor and patients filled out an assessment questionnaire that — on a scale from 4 to 1 (4 unsatisfactory, 3 moderate, 2 good, 1 excellent) — evaluated moisture, firmness, volume and definition (Table 1). At the same time, the potential side-effects were also evaluated, as listed in Table 2.
Results Of the 20 patients who enrolled in the study, 12 patients completed; six failed to follow the protocol correctly; and two patients continued with volume enhancement using a filler after the first session, enthusiastic about the results obtained during the
first few days, when a slight oedema was present. Despite some reluctance before the study, eight patients decided to try filler augmentation after completing the protocol.
Discussion The product’s safety profile was excellent, and any of the adverse events reported can be attributed to the HA’s hygroscopic properties and the infiltration technique used. Pain during infiltration, which was observed in less than half of the patients, did not warrant the interruption of a session, and could be further improved by adding anaesthetic to the preparation in the syringe. Pain was always limited to the time of administration and did not cause discomfort in the hours/days that followed. With regard to compliance, using a blunt cannula
rather than a needle presents certain advantages, such as a reduction in discomfort and pain for the patient and only a mild appearance of ecchymosis, observed in just two of the 20 patients — only in the area around the needle entry point and never along the injection line of the blunt cannula. This study was conducted in line with previous
Figure 2 SLEB evidence at baseline (A). Increased SLEB echogenicity after 4 weeks of treatment (B)
studies of non cross-linked HA 20 mg/ml, proving the moisturising action, improvement in elasticity, and reversibility of photo-induced damage. Specifically, a study by Coacci5
using instrumental techniques (DermaLab® USB skin testing, Cortex Technology), this substance, when administered intradermally, improves the
stated that when skin’s
elasticity and moisture, with a good degree of satisfaction for both the doctor and patient, and with an optimal safety margin. In 2008, Lacarrubba and Micali6
performed an
Figure 3 Evidence of reduced folds of the vermillion border and lip contour using Canfield Visia® computerised technology
ultrasound study of the skin using Viscoderm® HA, infiltrated once per week over a 4-week period. The results showed a statistically significant increase of subepidermal low-echogenic band (SLEB) echogenicity, likely related to an increased density of dermal collagen fibres by fibroblast activation resulting from treatment (Figure 2). The author and study partner7,8
have demonstrated
the product’s safety profile in this delicate treatment area and the degree of satisfaction expressed by patients, who only complained of excessive pain around the mucosal implant and the immediate presence of ecchymoses — characteristics that are typical of this infiltration technique, regardless of the material used. The main indications arising from the study were
Figure 4 Canfield Visia® ‘wood lamp’ showing both a reduction in wrinkles and an improvement in photo-induced age ‘spots’
54 ❚ October 2011 |
prime-journal.com
the treatment and prevention of reduced moisture, firmness and definition of the lips, as highlighted by the doctor and patient treatment assessments and the computer-processed polarised photographic images (Figure 3), which clearly show the reduction in the folds of the vermillion border and lip contour area and, therefore, better moisture of the skin and mucosae.
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