Garlic and cinnamon, parasites’ nightmare Garlic on its own may prevent or mitigate upon onset, a diversity of parasitic diseases in all animal categories. By adding cinnamon extracts, Alliin Plus widens this range of applications. In aquaculture, where garlic is already used against the white


faeces syndrome in shrimp caused by the combination of gregarines parasite and high levels of Vibrio spp., Excential Alliin Plus is applied to deter sea lice in aqua populations including cobia fish. Other species can benefit from the properties that comprise of Excential Alliin Plus. For example, in ruminants Excential Alliin Plus has been most


useful in the diet of young calves suffering from diarrhoea and Cryptosporidium. Excential Alliin Plus used in swine was tested against A.


pleuromoniae induced coughing and supports performance. Finally, for poultry application both garlic and cinnamon have


been reported to exterminate adult and juvenile red mites and their eggs. Additionally, Excential Alliin Plus may lower Eimeria counts responsible for coccidiosis and an indispensable factor for necrotic enteritis in chickens and may be used as a food safety initiative to reduce Salmonella populations prior to processing.


Supporting probiotic additives to lower necrotic enteritis In line with the worldwide trend to reduce growth promoting antibiotics and therapeutic antibiotic treatments, Excential Alliin Plus has earned its place within global ‘alternative to antibiotic’ strategies. Such strategies commonly champion the usage of probiotics as highly effective. Probiotics are defined as live microorganisms that have direct modulatory effects on the gut microflora. A very common example of feed additive probiotic is Bacillus subtilis. Broiler chicken are fast growers and their short life span restricts


the usage of sustainable solutions such as vaccinations. In this context, prevention and reducing onset of coccidiosis and Eimeria pre-


NELesionScores.Y axisincludetheproportionofbirdswhicheitherreceivedalesionscoreof0,1,2or3andtheaveragesaredepictedontop. 0=nolesionsand3=severe lesions.Thecontrolmodels(NegativeControlvsControl)depictthatNElesionswerepresentedasmoderatetosevere.Allbirdstreated(Antiobiotic Growth Promotor,BacillussubtilisC3102 at50ppm,AlliinPlusat450ppmorthecombinationofthese2)presentedlessseverelesions.Distributionofthelesionsiscrucial.The highlightedcombinationofAlliinPluswitheitherBSat50or30ppmhadover2/3ofthebirdsscoring0or1.


20% 40% 60% 80% 100%


0% NC CC AGP BS50 AP BS50AP BS30AP Different letters indicate p value < 0.05 Different letters indicate p value < 0.05 0.0d 2.3a 1.7b 1.2c 1.3c 1.1c 1.1c Scores


0 1 2 3


Summary In Excential Alliin Plus, garlic and cinnamon team up to replace antibiotics for a better gut health. Backed by an extensive number of trials, Excential Alliin Plus performs its highly beneficial effects in specific dosages on all animal species. The strong phytogenic feed additive Excential Alliin Plus appears to be supportive of other gut health solutions like probiotics, all working together in the quest of limiting the overuse of antibiotics and coccidiostats.


FEED COMPOUNDER MARCH/APRIL 2020 PAGE 41


NE Lesion Scores. Y axis include the proportion of birds which either received a lesion score of 0, 1, 2 or 3 and the averages are depicted on top. 0 = no lesions and 3 = severe lesions. The control models (Negative Control vs Clostridium Control) depict that NE lesions were presented as moderate to severe. All birds treated (Antiobiotic Growth Promotor, Bacillus subtilis C-3102 at 50 ppm, Alliin Plus at 450 ppm or the combination of these 2) presented less severe lesions. Distribution of the lesions is crucial. The highlighted combination of Alliin Plus with either BS at 50 or 30 ppm had over 2/3 of the birds scoring 0 or 1.


dispositioned necrotic enteritis (NE) can be achieved with coccidiostats, a specific category of antibiotic-like pharmaceuticals. Occurrence of NE is tightly connected to the presence of asymptomatic coccidiosis due to the Eimeria parasites. However, NE onset will only be triggered when Clostridium perfringens bacterium co-infects the bird’s gut. In this context, the use of B. subtilis as a gut flora stabilizer may prevent the development of C. perfringens in the gut. As feed additives do not claim to compete with pharmaceutical


solutions, combining complementary feed solutions is a well-established alternative. Excential Alliin Plus combines anti-pathogenic and anti- parasitic effects, likely to support those of the probiotic B. subtilis. In this context, a controlled study organised by an independent university tested the combination of B. subtilis with Alliin Plus. Low inclusion level of the probiotic (30 g/tonne of feed) was combined with Excential Alliin Plus (450 g/tonne of feed) in a mash feed. As shown in Table 1, this combination provided better protection against macroscopic gut lesions observed during NE, than the high dose of probiotic alone at a higher dose (50 g/tonne of feed). Also, broiler chickens that received Excential Alliin Plus alone were as well protected against early onset of NE as the birds receiving the antibiotic treatment. Protecting the broilers’ gut from NE-induced damages positively impacted the digestion performance of the birds as measured by improvement of the feed conversion ratio (Table 1).


FCR.Thecontrolmodels(NegativeControlvsColstridium Control)depictthatNEhadhighimpactonFCR.BirdstreatedwithAntiobiotic GrowthPromotor,Calsporin at50 ppm,orAlliinPlusat450ppmhadbetterFCRthanCC.ThisimprovementwasconsistentlyobservedwiththecombinationCalsporin andAlliinPlus,ashighlighted(inred). ThiswasregardlessofCalsporin dosage:50or30ppm,anditwasobservedatallperiods.However,whenlookingattheperiod021dayswhichincludesthehealthyperiod ofthebirds,onlythecombinationreachedstatisticalsignificance(seeinbold).


Table 1: FCR. The control models (Negative Control vs Clostridium Control) depict that NE had high impact on FCR. Birds treated with Antiobiotic Growth Promotor, Bacilllus subtilis C-3102 (BS) at 50 ppm, or Alliin Plus at 450 ppm had better FCR than CC. This improvement was consistently observed with the combination BS and Alliin Plus, as highlighted (in red). This was regardless of BS dosage: 50 or 30 ppm, and it was observed at all periods. However, when looking at the period 0-21 days which includes the healthy period of the birds, only the combination reached statistical significance (see in bold).


Treatments


NC CC


AGP BS50 AP


BS50AP BS30AP


0-21


1.336 c 1.926 a 1.827 ab 1.769 b 1.816 ab 1.752 b 1.690 b


14-21


-95 pts -67 pts


Different letters indicate p value < 0.05 NC non-challenged control BS Bacillus subtilis


Different letters indicate p value < 0.05 NC non-challenged control CC challenged control BS Bacillus subtilis AP Alliin Plus


1.404 f 3.154 a 2.628 bc 2.440 cd 2.691 b 2.206 e 2.469 cd


14-28


Prior to C. perfringens D14 Eimeria challenge Including challenge with C. perfringens


1.392 e 2.955 a


-81 pts -50 pts


2.710 abc 2.386 d 2.745 ab 2.142 d


2.451 bcd


CC challenged control AP Alliin Plus


-17 pts -24 pts


% Birds


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