Combined effects of garlic and cinnamon, a natural solution to reduce antibiotics use
Thanks to a unique technology, Excential Alliin Plus preserves the best of nature to boost animals’ gut health. Combining the broad range of benefits attributed to garlic with the powerful essential oil of the cinnamon bark, Excential Alliin Plus’ active ingredients have been reported anti-pathogenic, anti-inflammatory and pro-gut flora.
By Alexia Lépine, PhD, Central Technical Manager, Orffa Additives B.V.
Selection and stability of the garlic cloves Garlic’s fame in the world of health is most attributed to the chemically-defined garlic derivative allicin, an alkaloid thiosulphinate molecule identified as diallyl-dithiosulfinate. As in all plants, the natural levels of such active compounds may vary depending on the environmental conditions. Selection of thiosulphinate-rich cloves is therefore crucial to the production of Excential Alliin Plus. Allicin’s volatility causes practical and logistic constraints for effective
use in animal feed. Nature itself has found the best way to conserve the full effects of garlic active molecules by storing a precursor molecule and an activator but not allicin as such. Activated by the alliinase enzyme, allicin’s precursor molecule alliin transforms into allicin when the right conditions are met. While both alliin and alliinase are present in the garlic cloves, they are present in separate compartments. Allicin is formed only when alliin and alliinase get in contact through mastication or processing
of the garlic clove. Thus, preserving the integrity of their compartments by freeze-drying before milling is essential. Without this protection, the most powerful effects of the garlic molecules would easily be lost during storage and processing.
Garlic and cinnamon, an optimal team for multiple targets
Years of research have placed garlic and cinnamon at the top of the anti-pathogenic natural agents. These two plant-derived additives therefore qualify as phytogenics, or phytobiotics. Garlic’s active antimicrobial agents belong to the thiosulphinates,
of which allicin is generally claimed to be responsible for most of these benefits. Research indicates high effectiveness against pathogens, allicin may thus prevent digestive problems caused by, for example, E. coli, Salmonella and Rotavirus. However, providing the full garlic clove also confers effects linked to other sulfur compounds such as diallyl disulphide (DADS), S-allylcysteine (SAC) and diallyl trisulfide (DATS). Recent studies review the roles of phenolic and organosulfur compounds present in whole garlic in relation to anti-pathogenic as well as global health effects (Martins et al., 2016 Food Chemistry). Therapeutic uses and pharmacological properties of garlic are reported for protection against viral, bacterial, fungal, parasitic pathogens to support cardiovascular and immune functions. Cinnamon oil, the second component of Excential Alliin Plus,
contains agents that are reported to have gut health promoting properties. The predominant agent, cinnamaldehyde, accounts for around 80% of the oil’s composition. With a simple phenolic
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structure, cinnamaldehyde seems to feature a wide array of activities against countless bacteria, yeast and fungi. Various studies report that cinnamaldehyde actively mitigate E. coli, Salmonella enteritidis, Clostridium perfringens, and Aspergillus flavus. In addition to reducing the population of pathogenic agents, cinnamaldehyde stimulates intestinal secretions, improves absorptive capacity and modulates inflammation. The array of garlic and cinnamon’s functions together can serve
as alternative solution to growth promoting antibiotics as they affect the microbial populations and host responses, specifically anti-inflammatory properties. Although the mechanisms through which dietary antibiotics exert their growth promoting effects remain to be established, they are more and more suggested to improve growth performance through an anti-inflammatory effect directed toward the intestinal epithelium (Deepthi Gadde et al., 2018 Scientific Reports). This would also explain why growth promoting effects remain although resistance towards these same antibiotics rises. Growth promoting effects relying on the anti-inflammatory capacity of antibiotics like virginiamycin or bacitracin might well be replaced by a strong phytogenic solution like Excential Alliin Plus.
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