62 TABLETING
Containment processes forSOLID DOSAGE PRODUCTION
Tobias Borgers introduces new technologies for filmcoating and roller compaction I
n the pharmaceutical industry, one term is becoming increasingly important: containment. It describes the process of containing a substance within a defined space, a method that is suitable for protecting operators and the environment in case of high toxicity and product reactivity. At the same time, containment prevents dust, gases or vapours from being released into the environment and contaminating the product. More than 60% of pharmaceutical
products are produced as tablets, capsules, lozenges or similar solids. Especially in new products, the active pharmaceutical
ingredients (APIs) are becoming increasingly more potent. In some markets, the segment for high potency active pharmaceutical ingredients (HPAIs) is growing in the double-digit range, especially driven by oncology medication. In addition to requirements set by manufacturing guidelines, it is essential that the product is safe for the machine operator and, of course, for the patient. As a result, machine manufacturers such as L.B. Bohle are faced with new challenges in all toxicity classes in which customers want to use plants and processes. In 2017, numerous customers with special
specifications turned to the independent, medium-sized, family-owned company requesting, among other things, containment solutions for film coating applications and a dry granulation process. Two projects are examples of this.
Firstly, the Filmcoater BFC has been a sophisticated technology on the market for years and has guaranteed top-quality product processing and high profitability. Te BFC Filmcoater and its scaled-down version, the BTC, have achieved excellent market penetration. According to customer specifications,
the developers of L.B. Bohle designed a BFC 100 that meets the latest containment requirements.
Te containment version of the BFC 100 enables operation in closed driving mode thanks to:
automatic nozzle adjustment (stroke and angle)
infrared product temperature measurement
charging via a container flap the connection for cleaning the
container flap and the charging pipe (also available for discharge)
the connection for drying the container flap and the charging tube
the sampling lance side doors with inflatable gasket (also standard for BFC)
the demountable nozzle holder. Tis results in great advantages when it comes to cleaning
A second successful project is the design
The BFC 100 offers its user various benefits when it comes to handling, process technology and cleaning
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of a roller compactor from the BRC series. Already at the product launch in 2012, the BRC 25 and 100 were in high demand among customers. Te roller compactors of the BRC series are already popular in the market due to their flexible set-up or integration into the production process. Continuous dry granulation has been an established process in the pharmaceutical industry for decades and
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