Microscopy & Microtechniques 51 Dual-colour laser system for advanced microscopy
Toptica Photonics, a leading manufacturer of high-end laser systems, has introduced the FemtoFiber Ultra dual-colour laser system, specifi cally designed for advanced multi-colour non-linear microscopy applications. This innovative system is equipped with two synchronised laser lines, making it particularly well-suited for simultaneous multi-colour imaging and fl uorescence lifetime imaging (FLIM), without the need for laser wavelength tuning.
The FemtoFiber Ultra laser system enhances imaging of biological samples, with signifi cant benefi ts for metabolic imaging, such as simultaneous NADH and FAD measurements. The system’s shared oscillator design ensures all-optical synchronisation, providing a fi xed delay between the two colours with minimal jitter. Additionally, a single electronic trigger output serves as a reference for TCSPC and gated detection, simplifying the integration process.
Toptica’s femtosecond fi bre lasers are renowned for their optimal performance and ease of use, making them ideal for neuroscience applications. The FemtoFiber ultra lasers are particularly effective in addressing biological questions through imaging of green (GFP) and red fl uorescent proteins (RFP). These lasers are already widely adopted in non-linear microscopes, further cementing their position as a valuable tool in advanced microscopy.
More information online:
ilmt.co/PL/pwby 63246pr@reply-direct.com AI-enhanced workfl ows for advanced cell culture research
Leica Microsystems, a leader in microscopy and scientifi c instrumentation, is proud to announce the release of the Mateo FL, an AI-driven digital fl uorescence microscope designed to enhance cell culture analysis in advanced research settings. The Mateo FL integrates transmitted light for label-free imaging with multi-channel fl uorescence and automated analysis, revolutionising how laboratories conduct downstream experiments involving cell cultures.
Following in the footsteps of its counterpart, the Mateo TL, the Mateo FL merges user-friendly operation with a sleek, modern design. It offers advanced features for comprehensive cell analysis, including multi-modal imaging capabilities, AI-powered confl uency assessments, rapid and precise cell counting, and smart measurements for evaluating transfection effi ciency. Together, the Mateo TL and FL provide researchers with versatile tools to meet diverse experimental requirements.
“Mateo FL represents a signifi cant advancement in digital microscopy, providing researchers at all levels with an intuitive solution to streamline their workfl ows and achieve immediate results,” said James O’Brien, Vice President of Life Sciences and Applied Solutions at Leica Microsystems. “This innovation helps scientists expedite their research, minimise contamination risks, and safeguard data integrity, ensuring dependable, reproducible outcomes in the lab.”
The Mateo FL is equipped with a suite of automated workfl ows that guarantee consistent results, even with complex cell culture samples. It delivers accurate cell counts in just fi ve seconds, cutting down manual counting time by an average of 15 minutes. Additionally, the new automated phase contrast feature simplifi es image acquisition, further enhancing workfl ow effi ciency.
Designed with a compact, integrated structure, the Mateo FL minimises contamination risks by over 50% and boosts workfl ow effi ciency by capturing both monochrome and color images without the need to switch devices during an experiment.
For laboratories requiring stringent data management, the Mateo FL includes built-in audit trails and user management functions, ensuring compliance with FDA 21 CFR Part 11 standards. This makes it an ideal choice for the pharmaceutical research sector, where secure data tracking is paramount.
More information online:
ilmt.co/PL/LLyd 63249pr@reply-direct.com
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