Mass Spectrometry & Spectroscopy
From R&D to QC, making NMR accessible for everyone:
Putting NMR spectroscopy at the heart of the analytical chemistry lab William G. Hale, James T. Sagar, Rosie E. Jones, Robin J. Blagg, Oxford Instruments Magnetic Resonance
For many decades, access to nuclear magnetic resonance (NMR) spectroscopy has been an intrinsic requirement for any analytical chemistry lab. Due to its ability to elucidate molecular structure and track reaction dynamics, this technique is recognised throughout industry and academia as a powerful, non-destructive, non-invasive method, and is taught in undergraduate chemistry curricula. But how can NMR be employed on the bench in almost any laboratory environment?
Access to NMR has often been diffi cult, with the requirement for substantial space, special facilities and expert users, limiting the usability of the technique in synthetic chemistry and industrial labs.
range of challenges solved across education, academia, and industry.
However, recent advances in benchtop NMR instrumentation, brings this technique out of the basement or centrally managed facility, and into the heart of any laboratory. Benchtop NMR instruments are a smaller, cryogen-free version of traditional high fi eld instruments, and they even enable data collection in a fume hood. Oxford Instruments X-Pulse adds broadband capability to benchtop NMR.
This capability allows operators to use just one benchtop instrument and rapidly tune between most NMR active chemical nuclei.
This enables instrument sharing across many applications, future-proofs R&D capabilities and signifi cantly expands the
For industry, the benefi ts of small footprint, mobile, benchtop NMR are very clear: shorter preparation times, automation capabilities, fewer staff specialists, and a reduced space demand to name a few. This means time effi ciencies and cost savings versus high fi eld NMR instruments, which incur signifi cant initial capital investment and often require dedicated rooms to operate in. Benchtop NMR fi ts right alongside existing instruments in a lab or can be quickly transported on a trolley between labs. As benchtop NMR is cryogen-free, it is much cheaper to run than traditional high fi eld instruments. Our analysis showed that one can conservatively save over US$9,000 per year in running cost just from the cryogens alone.
Any business looking to invest in high fi eld NMR needs to answer these questions:
• Can one establish a reliable and continuous supply of liquid helium and liquid nitrogen?
• How will they be stored safely on site?
• Is there someone on site that is qualifi ed to handle them in a safe manner?
As well as the on-going, and ever rising cost of cryogens, there
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