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New HPLC columns to accelerate advanced therapy research
Thermo Fisher Scientific has announced the release of the SurePac Bio 550 SEC MDi and DNAPac RP semi-preparative columns. These new columns are designed to support the modern laboratory’s analytical, efficiency, and scalability needs, particularly in the development of advanced therapies.
The Thermo Scientific SurePac Bio 550 SEC MDi columns feature 3 µm monodisperse particles and inert (MDi) column hardware, offering superior retention of adeno-associated virus (AAV) monomers and higher resolution of aggregates in cell and gene therapy applications. These columns enable fast run times and achieve optimal separation efficiency, providing reliable results that can accelerate the delivery of novel therapeutics to the market.
The Thermo Scientific DNAPac RP semi-preparative columns are designed to aid laboratories in the expanding field of oligonucleotide therapies and precision medicine. Their unique chemistry delivers unmatched performance across a wide range of pH, temperature, and mobile phase compositions, ensuring precise separations and sample purification.
The SurePac Bio 550 SEC MDi columns are ideal for gene therapy and biopharmaceutical analytical laboratories that require size exclusion chromatography (SEC) for determining aggregates in AAV analysis. The DNAPac RP semi-preparative columns are suited for laboratories working with synthetic oligonucleotides, siRNA, ASO, and mRNA, enabling lab-scale purification of both small and large DNA and RNA oligonucleotides.
The SurePac Bio 550 SEC MDi columns offer enhanced efficiency and resolution due to high-resolution separation of AAV and aggregates, thanks to monodisperse particles that improve the homogeneity of packing and reduce peak broadening effects. MDi technology ensures consistent particle size distribution for column-to-column and batch-to-batch reproducibility, achieving consistent results and robust, easy-to-validate methods. The column’s 3 µm particles allow for the use of shorter columns to achieve the desired resolution compared to traditional 5 µm technologies, unlocking significant throughput improvements with faster run times and the ability to process more samples.
The DNAPac RP semi-preparative columns achieve superior reversed-phase resolution and efficient separation in lab-scale purifications. The particles’ wide operational pH range (0-14) and high-temperature range (up to 110 °C) make it ideal for supporting method development. The column chemistry is based on a super-macroporous structure with 4 µm DVB particles and a pore size range of up to 2000 Å, offering excellent separation of both short and long single- and double-stranded nucleic acids, including RNA modalities such as intact mRNA.
More information online:
ilmt.co/PL/N9ok and
ilmt.co/PL/jJvO 63013pr@reply-direct.com Dual-phase cartridges for streamlined PFAS testing
Waters Corporation announces the release of Oasis WAX/GCB and GCB/WAX PFAS Analysis Cartridges, designed to simplify and expedite sample preparation for EPA 1633 testing. These cartridges are engineered for analysing PFAS concentrations in non-potable water, soils, biosolids, and tissue. The innovative design reduces sample preparation time by 20% and cuts sample processing time by approximately 30 minutes per batch, enhancing efficiency and saving time and money for busy laboratories.
To ensure accuracy and confidence in test results, the Oasis cartridges are QC-tested by an accredited laboratory for low residual PFAS, reducing the need for troubleshooting contamination issues. Erin Chambers, Vice President of Consumables and Lab Automation at Waters Corporation, stated: “The new Oasis WAX/GCB and GCB/WAX Cartridges simplify and expedite complex sample preparations, replacing a laborious two-step process and significantly reducing preparation and processing time.”
The cartridges integrate two clean-up steps required by EPA Method 1633: a Weak Anion-Exchange (WAX) cartridge and dispersive solid phase extraction (dSPE) graphitized carbon black (GCB). This combination makes the cartridges faster and easier to use than traditional methods, eliminating manual steps such as weighing loose GCB, shaking, centrifugation, and filtration.
Amanda Cronin, PFAS Laboratory Supervisor at Katahdin Analytical Services and a beta tester for the cartridges, praised their efficiency, stating: “These cartridges save time and maintain laboratory cleanliness by eliminating the loose carbon step. The time savings is key for us, making the Waters cartridges our choice for efficiency.”
Oasis WAX/GCB and GCB/WAX Cartridges are the latest additions to Waters’ PFAS Testing Solutions portfolio, supporting the growing demand for PFAS environmental testing. In 2023, PFAS chemicals led to over $11 billion in legal settlements, and major regulations are expected this year under CERCLA and the Safe Drinking Water Act. Accurate PFAS testing is increasingly critical for compliance across various industries.
Waters Oasis WAX/GCB and GCB/WAX Cartridges meet all EPA Method 1633 requirements for aqueous and solid samples and are available in packs of 30 and 300 cartridges.
More information online:
ilmt.co/PL/W7p9 62843pr@reply-direct.com
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