Microscopy & Microtechniques 39 New upright microscopes enhance routine microscopy tasks
Leica Microsystems has introduced the Visoria series of upright microscopes, designed to improve the efficiency and comfort of routine microscopy tasks in industrial, life science, and clinical environments. The new series includes three models tailored to specific application needs: the Visoria B for life science and clinical labs, the Visoria M for materials science and quality control, and the Visoria P for polarisation microscopy, ideal for studying the optical properties of anisotropic materials and geological samples.
The digital versions of the Visoria microscopes allow users to view and analyse samples directly on a tablet, removing the need for a computer and eyepieces. This digital setup frees up valuable space in laboratory and production environments, enabling more efficient workflows. The Visoria series is powered by Leica Microsystems’ Enersight software platform, offering a consistent and user-friendly interface for a wide range of applications.
With ergonomically designed features, the Visoria series enhances user comfort, even during long hours of use. The microscopes include symmetrically positioned stage controls, adjustable focus knobs, and customisable stage height and torque to reduce strain and improve posture. The encoding functions allow users to streamline their tasks by automatically saving image parameters, including magnification and filter settings, in the image’s metadata, which helps save time and ensures consistency in results.
Designed with efficiency, comfort, and precision in mind, the Visoria series from Leica Microsystems provides an advanced solution for professionals across various fields, helping to simplify routine microscopy tasks and enhance productivity.
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New spinning disk confocal microscopes for live-cell imaging
Two spinning disk confocal microscopes - IXplore IX85 SpinXL and SpinSR - have been introduced by Evident to support advanced live-cell imaging and super- resolution studies. Both systems are built on the IXplore IX85 automated inverted platform and offer improved acquisition speed, resolution, and sample protection.
The SpinXL, based on CrestOptics X-Light technology, delivers a 26.5 mm field number for rapid screening of large areas. Dual-camera support and near-infrared compatibility enable deeper imaging with minimal phototoxicity, making it well-suited for dynamic, high-throughput experiments.
The SpinSR, incorporating Yokogawa CSU-W1 technology and the TruSight SR algorithm, achieves lateral resolution down to 120 nm. It enables detailed time-lapse imaging of subcellular structures, with real-time control and intensity-preserving processing suitable for quantitative workflows. A 3D processing algorithm extends performance into organoid and deep-tissue samples.
Both systems are compatible with the LUPLAPO25XS silicone immersion objective, enabling improved 3D volumetric reconstruction and imaging at depth.
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Super-resolution microscope for single-molecule research
ONI has launched the Aplo Scope, a single-molecule super-resolution microscope designed to capture and analyse molecular interactions with unmatched precision. This advanced system enables researchers to explore nanoscale biological structures in real-time, overcoming limitations of traditional imaging techniques.
The Aplo Scope provides a seamless transition from low-power live-cell imaging to high-resolution microscopy at 20 nm resolution, eliminating the need for complex hardware adjustments. Its compact benchtop design integrates cutting- edge imaging technology with automated workflows, allowing scientists to investigate cellular structures in depth and accelerate discoveries in drug delivery, biomarker identification, and antibody therapeutics.
“The future of biology and drug development depends on our ability to visualise molecular interactions with extraordinary clarity,” said Paul Scagnetti, CEO of ONI. “The Aplo Scope delivers the precision and speed required to unlock new insights, pushing the boundaries of what’s possible in medicine.”
Equipped with a custom-engineered laser module offering precise power control (0.01 kW/cm² to 4.0 kW/cm²), the Aplo Scope enables effortless shifts between live-cell imaging and super-resolution at the click of a button. Its advanced filter set and intuitive software simplify complex assays such as multi-colour imaging and time-lapse studies of biological processes.
Researchers worldwide recognise the impact of single-molecule localisation microscopy (SMLM) in understanding disease mechanisms, improving drug discovery, and advancing patient stratification. “This technology has transformed our approach to biomedical research, revealing insights that were previously inaccessible,” said Lorenzo Albertazzi, Associate Professor at TU/e’s Department of Biomedical Engineering.
ONI designed the Aplo Scope as part of the Aplo Platform - an integrated solution combining application-specific kits and cloud-based software. By streamlining workflows and enhancing data analysis, ONI continues its mission to make super-resolution microscopy both powerful and accessible, helping scientists uncover the molecular foundations of health and disease.
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Linkam Scientific Instruments, a market leader in temperature- and environment-controlled microscopy, has partnered with the University of Huddersfield to develop the IHS1700, a groundbreaking new infrared heating stage. The IHS1700 reflects a major advancement in thermomicroscopy, combining state-of-the- art infrared technology with precise temperature control for rapid heating.
The IHS1700 offers a temperature range from room temperature up to 1700°C and has an impressive maximum heating rate of 2000°C/min. This advanced heating stage has been rigorously tested by researchers at the University of Huddersfield in their work on metallurgy, mineralogy, and energetic materials analysis, with the results set to be highlighted during the TAC 2025 presentation.
Designed specifically for the study of inorganic materials, the IHS1700 is ideal for high-temperature research, providing excellent atmosphere control in a compact volume.
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