Reagents, Reference Materials & Laboratory Chemicals
Defi ned hydrogel enables reliable cancer cell culture in xenograft models
AMSBIO has introduced MatriMix for PDX, a fully defined extracellular matrix (ECM) hydrogel specifically formulated to support patient-derived xenograft (PDX) studies. Comprising collagen type I, laminin-511 E8 fragments, and hyaluronic acid, this ready-to-use 3D culture substrate provides an optimised environment for culturing patient-derived cancer cells.
PDX models utilise tumour tissue from patients to establish tumours in immunodeficient mice, preserving the histological and genetic characteristics of the original tumour. These models offer an advanced platform for cancer research, enabling drug screening and toxicology studies to facilitate the development of novel treatments.
MatriMix for PDX is designed to deliver high lot-to-lot consistency, ensuring reproducible results for researchers. Its composition has been carefully optimised to create an ideal extracellular environment, supporting even challenging-to-culture cancer cell types in xenograft applications.
The hydrogel is made with medical-grade porcine collagen, facilitating a smooth transition from basic to clinical research, setting it apart from traditional natural hydrogels. Supplied frozen, MatriMix for PDX forms a clear gel when warmed to physiological temperature (37ºC), enabling enhanced visualisation for real-time monitoring of tumour growth, invasion, and drug response assays.
MatriMix for PDX is available in a convenient, single-vial format, as well as a tunable three-vial version, allowing users to customise conditions for specific 3D cell culture or organoid models.
More information online:
ilmt.co/PL/BNY1 63837pr@reply-direct.com
High-precision synthetic sediment standard for IRMS and TOC
Elemental Microanalysis, a global leader in elemental analysis supplies, has introduced the first in a new series of synthetic sediment standards designed for isotope ratio mass spectrometry (IRMS) and total organic carbon (TOC) analysis.
The new reference material, B2251, replicates the elemental composition of natural sediment using carefully selected mineral and chemical ingredients. This synthetic approach allows for precise tailoring to match specific matrix requirements, offering researchers a closer fit for their analytical needs.
B2251 is a high-organic-content sediment standard certified for TOC, total carbon, nitrogen, and sulphur. Elemental’s R&D team plans to expand the range during 2025, developing additional synthetic standards to support studies on carbonate removal techniques and to simulate the IRMS behaviour of previously sourced natural soils and sediments.
Synthetic standards offer key advantages over natural equivalents: greater batch-to-batch consistency, fewer regulatory hurdles, and simplified global shipping thanks to the absence of export controls linked to irradiated natural soil.
Elemental Microanalysis also supplies a broad selection of synthetic soil standards certified for carbon, nitrogen, and sulphur content. More information online:
ilmt.co/PL/O546
64703pr@reply-direct.com Quality reagents and custom solutions for molecular biology
Founded in 2002, Bioron GmbH specialises in high-quality molecular biology reagents, supplying a wide range of DNA, RNA products, and tailored solutions to support biotechnological research, diagnostics, and therapeutic development. The company has built a strong reputation for ethically sourced, highly pure human DNA products, including its fl agship Human Placenta DNA and COT I Human DNA.
Human Placenta DNA, derived from placental tissue, is widely used in chromosomal and whole genome analysis, FISH, Southern blotting, genomic library construction, and PCR-based assays. COT I Human DNA, enriched in repetitive sequences, is especially valuable for next-generation sequencing (NGS) and ensures high specifi city in diagnostic and genetic testing.
Bioron’s extensive product range also supports PCR technologies with enzymes, master mixes, reverse transcription kits, nucleotides, DNA ladders, and purifi cation kits. These products are designed to meet the rigorous standards of academic and commercial laboratories, delivering reliable, high-performance results for molecular diagnostics and research.
Committed to quality and regulatory compliance, Bioron maintains ISO 13485:2016 certifi cation and adheres to Good Manufacturing Practices (GMP), ensuring products meet international standards for clinical trials, diagnostic testing, and therapeutic applications.
Customer-focused from small-scale development to large orders, Bioron offers tailored product specifications, rigorous quality control, and personalised support. Their flexibility and expertise make them a trusted partner in advancing biotechnology research and medical innovation.
With a comprehensive portfolio, regulatory rigor, and dedication to customer needs, Bioron GmbH continues to play a key role in providing essential molecular biology reagents and reference materials worldwide.
More information online:
ilmt.co/PL/lQGO 64851pr@reply-direct.com
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