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New multicomponent standard streamlines nitrosamines testing
Restek introduces the Nitrosamines 7 Standard, a novel multicomponent solution designed to streamline pharmaceutical impurities testing. This innovative product consolidates seven key nitrosamines into a single ampul, alleviating the complexity and challenges associated with sourcing individual compounds. By offering a comprehensive selection of frequently targeted nitrosamine compounds, Restek aims to enhance the efficiency and accuracy of laboratory testing procedures.
The Nitrosamines 7 Standard serves as a certified reference standard (CRM), providing laboratories with a reliable internal standard for nitrosamine analysis. With its formulation optimised for stability, each analyte is present at a concentration of 100 µg/mL, facilitating the construction of calibration curves and ensuring consistent and accurate results. This standardised formulation not only simplifies sourcing but also minimises the need for time-consuming standard preparation procedures.
Furthermore, the Nitrosamines 7 Standard is available in two independently manufactured lots, each accompanied by verified lot-to-lot agreement. This ensures consistency and reliability across different batches,
enabling laboratories to maintain high standards of quality control and data integrity. Additionally, an internal standard is included at a concentration of 1000 µg/mL, further enhancing the accuracy and reproducibility of analytical measurements.
More information online:
ilmt.co/PL/kAw8 62422pr@reply-direct.com Positive pressure manifold enhances sample preparation
Porvair Sciences introduce the new UltraPPM LITE positive pressure manifold for sample preparation. A simple, reliable and reproducible instrument for increasing throughput of multiwell processing plates.
The Porvair UltraPPM features an interchangeable head design that allows for a simple user switch between 96, 48, 24 and 384 well filter plates. This makes it the most versatile pressure manifold available and ideal for laboratories with changing projects.
Additionally, the UltraPPM LITE has been manufactured with a gas flow path free from fluorinated polymers, making it suitable for PFAS analysis. Sample dry-down is an essential step in a number of EPA methods for the analysis of PFAS, and it is therefore prudent to reduce any potential contamination introduced by the measuring system.
Many sample preparation process’ require solvent to pass through a filter held within a multiwell plate. The filter itself might be
a simple particulate filter, or a more complex chemically active system to extract target analytes from a sample. In any application the filter acts to resist the flow of the sample and solvents, which can lead to delays and long processing times. For many years Porvair Sciences has manufactured a vacuum manifold the increases the pressure difference across this filter thereby decreasing the time needed to process a plate. The alternative is to apply a positive pressure to the head of the plate forcing the solvent through rather than pulling it.
Positive pressure has a number of advantages over vacuum. Vacuum may not be strong enough when analysing viscous samples, the gas source used can be controlled unlike using lab atmosphere, it is easier to operate since there is no vacuum release required, which needs to be carried out in a controlled slow way to prevent disturbing the collected eluants and potentially cross contamination.
More information online:
ilmt.co/PL/0MX9 62049pr@reply-direct.com Automated chromatographic modelling and optimisation software
S-Matrix is a world technology leader in Automated Quality-by-Design (QbD) Software to support Chromatographic Analytical Method Development, Validation, and Transfer. S-Matrix’s Fusion QbD® Software is a comprehensive integration of chromatography modelling and advanced statistical tools supporting all stages of Analytical Procedure
Lifecycle Management (APLM). Flexible Design of Experiments (DoE) technology, automated UV and MS spectra based peak tracking, and hyper- precise chromatographic modelling of any integrated peak results enable Fusion QbD to support all chromatographic separation modes and all stages of method development from identifying initial method conditions through chemistry system screening (method scouting) to final robust method optimisation, including full forced degradation study automation and integrated robustness simulation for all included critical System Suitability performance characteristics throughout the entire experimental region – the correct basis for accurately establishing the robust Method Operable Design Region (MODR). Fusion QbD also supports Sample Preparation method optimisation and Replication Strategy optimisation with full integration of USP <1210> Interval metrics. Additionally, Fusion QbD contains a full automated experimentation suite for method validation and transfer. Fusion QbD is 100% aligned with all current regulatory guidances and contains the core QbD methodologies and tools presented in ICH Q2(R2), ICH Q14, and USP <1220>. Fusion QbD’s strategic regulatory compliance and data integrity support features include full CDS automation with ChemStation, Chromeleon, and Empower with complete bi-directional audit trail, full Part 11 compliance support, and a built-in Project Management System.
More information online:
ilmt.co/PL/zzYD and
ilmt.co/PL/pK6y 62086pr@reply-direct.com
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