9
changes in fl ow rate as found when check-valves or gaskets of a pump are not 100% functional but not yet failing completely.
The term ‘Non-Invasive’ might sound strange in the context of fl ow measurement as any accurate measurement requires physical contact with solvent. In the context of the described fl owmeter and HPLC/uHPLC pump validation, however, the term explains that the tool (the fl owmeter) can be connected at the very end of the HPLC/uHPLC system and does not therefore introduce any additional volume or back pressure which might negatively infl uence the system performance. The fl owmeter does not ‘invade’ the system with negative properties and does not disrupt operation.
In fact, such non-invasive fl owmeters are being evaluated to become a permanent component of HPLC/uHPLC systems delivering fl ow data directly to a Chromatography Data System along with all other detectors present, thereby enabling continuous validation of fl ow.
Use of a non-invasive fl owmeter for the tasks performed by an HPLC/uHPLC Service Engineer offers numerous advantages compared to using traditional gravimetric or volumetric test methods. The biggest benefi t is that these new generation non-invasive fl owmeters reduce needed time for completion of the on-site service job. In addition, these devices offer service engineers the possibility to offer early identifi cation of an underlying problem like a sticking check-valve or a bearing with a micro-leakage. Adding pre-emptive service measures will lead to less equipment downtime and higher HPLC/uHPLC user satisfaction.
Looking to the future, permanently connecting a non-invasive fl owmeter to an HPLC/uHLPC system, and storing real-time
Figure 3: Saving HPLC fl ow and chromatographic data in real time
fl ow data along with chromatographic data, offers the potential for a fi eld service engineer to access the full history of pump performance since the last validation.
In conclusion, Field Service Engineers are vital for assuring the quality of performance of all HPLC/uHPLC systems. The best available tool for HPLC / uHPLC pump validation, fl ow measurement and fl uidic troubleshooting today is undoubtedly a non-invasive real-time liquid fl owmeter. For further information please visit:
https://www.testa-analytical.com/
hplc-chromatography.html
The author: Carlo Dessy is Managing Director of Testa Analytical Solutions eK, a respected international developer and supplier of instruments, innovative detectors and software for chromatography applications and molecular weight determination. He may be contacted on
cdessy@testa-analytical.com
Reconditioned and exchanged parts for your lab equipment
LC Services understands the fi nancial strain and operational impact of replacing laboratory equipment. With their exchange program, customers can acquire reconditioned parts and return faulty ones, receiving a credit for future purchases or a refund. If customers lack exchange items, they can still purchase reconditioned parts.
LC Services ships globally and stocks various chromatography equipment parts, all rigorously tested and inspected for quality and performance. Additionally, they offer fully refurbished chromatography equipment, tailored to meet laboratory needs, with global shipping and a six-month warranty. UK customers enjoy free installation. The exchange process involves purchasing reconditioned items, shipping, returning defective items within four weeks, and receiving a credit or refund based on the price difference.
More information online:
ilmt.co/PL/0M7A New HPLC system enhances biopharma QC effi ciency
Waters has introduced the Alliance iS Bio HPLC System, a revolutionary solution tailored to address the unique operational and analytical hurdles encountered by biopharma quality control (QC) labs. Engineered to optimise effi ciency, ensure compliance, and accelerate product delivery, this system is poised to meet the stringent requirements of the biopharma industry.
With a focus on enhancing productivity, the Alliance iS Bio HPLC System targets common errors, aiming to eliminate up to 40% of these occurrences. By minimising the time spent on investigating failed runs and out-of-specifi cation results, QC analysts can streamline their workfl ow and expedite sample analysis.
Featuring a bio-inert design in critical internal components, including the system fl ow path, this innovative solution mitigates unwanted interactions from metal-adsorbing analytes. This safeguard ensures the integrity of the analysis, providing reliable and accurate results.
The system offers the fl exibility to leverage platform methods with confi dence, reducing the need for extensive column conditioning and method development. This capability not only saves time but also enhances the effi ciency of the QC process.
More information online:
ilmt.co/PL/7nv1 62639pr@reply-direct.com
62533pr@reply-direct.com
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