Chromatography 19
Robust bioinert columns for a new level of recovery YMC Accura BioPro IEX columns
Ion exchange chromatography (IEX) is widely used for Bio QC methods, especially for charged variant analyses. Sensitive substances like oligonucleotides tend to interact with column hardware, even with quite inert IEX standard hardware made of PEEK. Adsorption of the analytes on the surfaces lead to peak tailing, carryover, and reduced recovery.
Bioinert column hardware as solution
YMC meets this special challenge with the recently launched YMC Accura columns. They feature a bioinert surface coating of the column body and frits. The robust bioinert coating used on YMC Accura hardware is 130 to 320-fold thicker compared to similar hardware concepts. Permanent inertness against sensitive substances is ensured. Therefore, YMC Accura columns can even be used for the analysis of sensitive substances without pre-conditioning.
The Selectivity Company Ideal stationary phases
The non-porous hydrophilic polymer beads of the BioPro IEX stationary phases enable exceptionally high efficiencies and high throughput analyses. Even small sample variations can be easily separated and detected. The superior lot-to-lot reproducibility guarantees highly reliable results. BioPro IEX SF with its strong cation exchanger functionality is particularly ideal for analysing charge variants of monoclonal antibodies (mAbs) or other proteins. The strong anion exchanger BioPro IEX QF is the first choice for high-resolution analysis of oligonucleotides of different lengths as well as mAbs with lower pI.
Benefits from using YMC Accura BioPro IEX columns
The combination of the bioinert coated column hardware and the high efficiency stationary phases of YMC Accura BioPro IEX columns provide excellent peak shapes for sensitive compounds. They ensure high recovery from the very first injection and prevent carry-over. YMC Accura BioPro IEX columns are not only very inert, but are also available with smaller column IDs, making them ideal for use in native IEX-MS analysis.
More information online:
ilmt.co/PL/KYke and
ilmt.co/PL/34j1 62489pr@reply-direct.com
Your Experts in Reproducible Analyses
Specifi cally designed BioLC columns
For proteins/peptides, mAbs, ADCs and oligonucleotides
Fully bioinert (U)HPLC Coated, PEEK and PEEK-lined columns
Superior performance and reproducible separations
Reliable results, high throughput and long column lifetimes
YMC’s Expertise Portal will always keep you up to date
www.ymc.eu |
support@ymc.eu | +49 2064 427-0
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108 |
Page 109 |
Page 110 |
Page 111 |
Page 112 |
Page 113 |
Page 114 |
Page 115 |
Page 116 |
Page 117 |
Page 118 |
Page 119 |
Page 120 |
Page 121 |
Page 122 |
Page 123 |
Page 124 |
Page 125 |
Page 126 |
Page 127 |
Page 128 |
Page 129 |
Page 130 |
Page 131 |
Page 132 |
Page 133 |
Page 134 |
Page 135 |
Page 136 |
Page 137 |
Page 138 |
Page 139 |
Page 140 |
Page 141 |
Page 142 |
Page 143 |
Page 144 |
Page 145 |
Page 146 |
Page 147 |
Page 148
