21 Particle Characterisation Characterising Complex Polymers in Challenging Solvents
The AYE Combo from Testa Analytical is a unique GPC/SEC detector designed to have a high performance refractometer as an integral part of a viscometer, allowing both concentration and viscosity to be measured at exactly the same time on the very same sample segment.
As a consequence the AYE Combo Refractometer/Viscometer detector enables a much more accurate determination of molecular parameters and is particular suitable for applications focused on determining the structure and branching of complex polymers.
GPC/SEC is widely acknowledged as a primary analytical technique for characterising polymers. The latest generation of complex high performance polymers however, add a notable degree of complication by requiring the use of ‘challenging’ solvents such as DMSO, DMF and HFIP to dissolve them. Unfortunately, most GPC/SEC systems require frequent maintenance when operating with these solvents.
Drawing upon pressure transducers made out the most stable alloy available combined with highest grade 316T capillary tubing The AYE Combo detector is gaining rapid recognition as the GPC/SEC detector of choice for characterising complex polymers in challenging solvents.
More information online:
ilmt.co/PL/ZJrX 52452pr@reply-direct.com
A New Dimension in Particle Analysis
Characterising Virus and Virus-Like Particles
Postnova Analytics reports how its latest generation of Asymmetrical Flow Field Flow Fractionation (AF4) systems are providing labs worldwide with a uniquely powerful technique to characterise and quantitate virus and virus-like particles.
Virus and virus-like particles are widely used in the healthcare industry for vaccination via immune response stimulation. Because these particles are to be injected into patients there is a critical requirement for a technique that allows detection and separation of the monomeric, oligomeric and aggregated species in a typical formulation.
While Size Exclusion Chromatography (SEC) has been a traditional analytical technique used for this application it has significant limitations relating to the size exclusion limit of the separation column that restricts the upper molar mass and particle size range that can be measured.
By comparison, Asymmetrical Flow Field Flow Fractionation (AF4) is an advanced separation technique that can address the problems associated with SEC. In AF4, an open, unpacked separation channel is used in place of a packed column.
The Microtrac MRB SYNC Analyzer provides traditional users of laser diffraction technology with exciting new capabilities to characterise their materials. The proven tri-laser technology provides accurate and repeatable laser diffraction information from light detected over 163 degrees of angular scatter. When combined with state-of-the-art camera technology capturing images of the particle stream at the same time, the SYNC offers not only size data but significantly more information about the shape of the materials and the quality of the dispersion.
The patented Synchronous measurement technology of the SYNC allows users to make both a laser diffraction measurement and an image analysis measurement on a single sample, in the same sample cell at the same time: One sample, one optical bench, one flow path, one sample cell, one integrated GUI, one analysis.
This makes the SYNC ideally suited for both routine QC and research applications; it provides valuable information to researchers as they develop new materials and processes. The powerful software interface offers both particle size distribution information as well as a multitude of morphological parameters. The patented BLEND routine allows users to examine materials over a wide size range from 0.01 microns to 4000 microns
More information online:
ilmt.co/PL/Bd9R 52569pr@reply-direct.com
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Low-fi eld NMR Instrument for Complex Nanoparticle
Suspensions Characterisation Mageleka Inc is a scientifi c instrumentation company focused on the analysis and characterisation of complex, multi-component nanoparticle suspensions. The company was founded by a group of entrepreneurs with many years experience in industry, academe and in the development of analytical instrumentation. The new Magnometer XRS, is based on low-fi eld nuclear magnetic resonance and is now available.
The technique can characterise dispersions made with any nanoparticle and is sensitive to both surface and solution chemical environments and adsorbing additives such as polymers and surfactants: it is ideal for quality control. Applications include batch-to-batch reproducibility in a manufacturing environment and raw materials control. The technique is simple to use and does not require sample preparation with most measurements performed in under 2 minutes. Current customers include
catalyst companies, pharmaceutical and personal health care providers. More information online:
ilmt.co/PL/wZvD
52276pr@reply-direct.com
The absence of a stationary phase in AF4 systems results in the ability to use a wider range of solvents, elimination of SEC shear force and matrix interaction effects as well as the ability to separate particles over a very wide size range, from 1 nm up to above 1 µm. These capabilities enable AF4 to provide a complete picture of virus and virus-like particles including monomer content, insoluble and soluble aggregates, as well as the subvisible particle fraction.
More information online:
ilmt.co/PL/Q0QP 52453pr@reply-direct.com
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