Proteomics, Genomics & Microarrays


CD47 Protein Products for Cancer and Cardiovascular Research


Amsbio has announced a new range of CD47-relevant products suitable for rapid high throughput screening studies. CD47, or Integrin associated protein (IAP), is a transmembrane protein that in humans is encoded by the CD47 gene. Studies have established that CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion and migration. Furthermore, CD47 is known to be a key regulator of tissue homeostasis, and is also involved in a variety of diseases ranging from atherosclerosis to cancer. Given its significant role in pathogenesis of cancer and cardiovascular diseases, CD47 signalling has been heavily investigated for new targeted therapeutics.


The unique set of CD47-relevant products from Amsbio includes human CD47 protein and multiple avi tag pre-biotinylated proteins. Derived from Human (HEK 293) cells, Amsbio CD47 protein products demonstrate superb bioactivity, high detection sensitivity and authentic post translational modification and protein conformation. The new Amsbio CD47 protein kits are supplied as pairs of products that can be easily adapted to ELISA, AlphaLISA™ and MSD platforms to facilitate rapid and easy screening of the neutralising compound.


44277pr@reply-direct.com Alternative CRISPR Genome Editing Method Developed


Merck has developed a new genome editing tool that makes CRISPR more efficient, flexible and specific, giving researchers more experimental options and faster results that can accelerate drug development and access to new therapies.


This new technique, called ‘proxy-CRISPR’, provides access to previously unreachable areas of the genome. Most natural CRISPR systems, found in bacteria, cannot work in human cells without significant re-engineering. However, proxy-CRISPR provides a rapid and simple method to increase their usability without the laborious need to re-engineer native CRISPR proteins.


The company has filed several patent applications on the proxy-CRISPR technology. These patent applications directed to the proxy-CRISPR technology are just some of several CRISPR patent application filings made by the company since 2012.


42933pr@reply-direct.com ADVERTORIAL Going to the eXTReme - A new Range of Peak Performance Plate Seals


When performing PCR or storing samples for future use, it’s important that your plate seal performs well to ensure you get the very best results from your precious samples. The eXTReme™ Sealing Films and Foils for PCR and Storage are the newest additions to Excel Scientifi c’s Pressure Adhesive Sealing Films line, available in the UK from Alpha Laboratories.


eXTReme fi lms offer high performance under extreme conditions. They feature a specially formulated adhesive that provides an excellent seal for all plate materials and is especially well suited for dual component (polycarbonate/ polypropylene) PCR plates.


What’s more, eXTReme Sealing fi lms remove cleanly from plate surfaces without adhesive stringing, residue or contamination. Each sealing fi lm offers suffi cient sealing area for all plate types (e.g. fl at top and raised-rim). The seal will not extend beyond the top edge of the plate and together with the chamfered corners, eXTReme seals are ideal for robotic handling applications. An end-tab feature allows for easy placement of fi lm to plate. The seals are certifi ed DNase- and RNase- free.


The eXTReme clear fi lms are ideal for PCR and storage applications to minimise sample evaporation and reduce well-to-well cross contamination. The 50 µm polyester fi lms feature two end-tabs with perforations and will not tear on removal. They can be used within the temperature range -40ºC to +120ºC.


NON-SKIRTED PLATES FOR PERFECT PCR


Designed to fit a wide range of leading thermal cyclers


Find out more at www.alphalabs.co.uk/pcrconsumables


▪ Fully automated manufacturing and packaging to meet high quality specifications


▪ Uniform thin wall section for rapid, even and consistent thermal transfer


Alpha Laboratories Ltd 40 Parham Drive Hampshire SO50 4NU UK


▪ Excellent temperature control for reproducible protocols and maximum yields


Tel: ▪ Standard, Low Profile and Chimney Top well options Email:


+44 23 8048 3000 sales@alphalabs.co.uk


Web: www.alphalabs.co.uk Plates and Seals for Perfect PCR_Oct2017.indd 3 8266ad@reply-direct.com 11/10/2017 09:36:19


eXTReme FoilSeal™ is made of 48 µm thick aluminium foil to minimise shredding during removal. It can be used for PCR, long-term compound and cold storage, light sensitive assays and robotics to provide excellent barrier properties and minimise sample evaporation. They can be used within the temperature range -80ºC to +120ºC. The foil is conformable to allow visual verifi cation of seal security and a single end- tab features a custom perforation that will not tear during removal. eXTReme FoilSeal is DMSO resistant and pierceable with pipette tips and robotic probes for direct sample retrieval.


Try now and save 20% when you order online or Quote Offer Code LV153 until 31st December 2017.


Find out more at www.alphalabs.co.uk/xtr 44164pr@reply-direct.com


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