Mass Spectrometry & Spectroscopy 11


Patent Approval for Tandem Ionisation Announced Markes International has announced that its US patent (US 15/231,383) for Tandem Ionisation®


Tandem Ionisation is the latest extension of the company’s patented Select-eV® has been approved. technology (US Patent Number 9,524,858). Select-eV is the


technology enabling acquisition of both reference-quality 70 eV spectra and repeatable ‘soft-ionisation’ spectra without the loss in sensitivity, use of chemical reagents or hardware changes that have historically been associated with soft ionisation. This award-winning way of producing both ‘hard’ and ‘soft’ EI mass spectra greatly speeds up the process of differentiating between similar compounds, such as structurally similar isomers and identifying unknowns.


Tandem Ionisation builds on the Select-eV technique by ‘multiplexing’ ionisation energies, allowing two sets of spectra to be simultaneously acquired across a single GC or GC×GC peak – both 70 eV spectra for spectral matching against commercial libraries, and the soft ionisation spectra.


Alun Cole, Founding Director at Markes International, said: “Since 2014, we have worked to establish soft EI as an essential component of the GC–MS toolbox and we are thrilled that the technology continues to gain momentum. With Tandem Ionisation, BenchTOF-Select is the only instrument capable of providing analysts with all the information required for reliable compound identification in a single GC or GC×GC run.”


The Tandem Ionisation patent has been approved in the US and is patent-pending in a number of countries across the world. 43621pr@reply-direct.com


New XRD System Announced at JASIS 2017


At the Japan Analytical Scientific Instruments Show (JASIS), Bruker announces the new D8 DISCOVER PlusTM DISCOVER Plus combines the high power of the new TXS-HETM high endurance ATLASTM


high-efficiency Turbo X-ray SourceTM goniometer.


The TXS-HE is optimised to deliver an extremely high intensity X-ray beam without compromising flexibility to meet the most demanding analytical needs in today’s research, development and process control. The TXS-HE significantly reduces data collection time compared to conventional X-ray sources and delivers better data quality, giving new insights into structural properties of investigated materials. Further, the additional speed of the TXS-HE enables the studies of dynamic processes including time dependent phase transitions and kinetics in materials better than ever before.


The advanced design of the new ATLAS goniometer delivers an even higher level of angular positioning accuracy, thus increasing the reliability of measured data for all applications. It is extremely robust ensuring that this level of performance is maintained for all configurations from classic powder diffraction to epitaxial thin-film characterisation. As a result, the D8 DISCOVER Plus with ATLAS goniometer even tops Bruker’s unique total system alignment guarantee, setting the new standard for XRD laboratory systems.


By combining the high X-ray flux of the TXS-HE, the outstanding accuracy of the ATLAS goniometer, and the large detection area and dynamic range of the new EIGER2 R 500K multi-mode Hybrid Photon Counting (HPC) detector, the D8 DISCOVER Plus offers unmatched capabilities for the analytical tasks in materials research and analysis.


“With the introduction of the D8 DISCOVER Plus, Bruker once again sets new standards in XRD instrumentation. The D8 DISCOVER Plus is designed to deliver top-class results for structure analysis of all kinds of materials, from powders in the pharmaceutical industry to crystalline structures in semiconductor devices, and is a further step to strengthen Bruker’s position as the provider of the most powerful and user- friendly XRD solutions on the market,” stated Dr Lutz Bruegemann, General Manager XRD and Vice President of Bruker AXS.


43896pr@reply-direct.com X-ray diffraction (XRD) system. The D8 with the unrivalled reliability and accuracy of the new


Extended Range of Certified Reference Materials (CRMs) and Associated Calibration Services Announced


Since achieving accreditation to the internationally recognised ISO/IEC 17025 standard as a Calibration Laboratory in June 2001, by the United Kingdom Accreditation Service (UKAS – 0659B), Starna Scientific has continued to develop and evolve this support for spectroscopy Certified Reference Materials into the comprehensive service it has now become.


The manufacturing and development base for this program was endorsed further by the accreditation of Starna Scientific by UKAS in June 2006, as the first Reference Material producer in the UK to be accredited to ISO Guide 34 (UKAS – 4001), after its key role in the associated pilot study.


In November 2016, ISO Guide 34 was formally recognised as a standard by ISO, becoming ISO 17034, and a part of this continuing evolution and the increasing demand for CRMs, Starna Scientific has taken this opportunity to make available an expanded manufacturing and certification program under these two complimentary standards.


To its extensive, and potential customer base, this now means Starna Scientific have the capability to provide this accredited calibration service across a much broader range of both new and existing CRMs.


This extension allows Starna Scientific entry into new spectroscopic areas such as Fluorescence, Raman, etc. and offers the capability for customers to (re)certify appropriately manufactured CRMs or standard materials currently being used within their own environment; and thereby provide the appropriate certification, consistent with the requirements for accreditation to ISO/IEC 17025.


41665pr@reply-direct.com Evaporative Sample Preparation for Mass Spectrometry


Genevac has established a new web page that brings together customer technical articles that illustrate how centrifugal evaporation has become a sample preparation technique of choice for laboratories that seek to analyse complex samples using hyphenated mass spectrometry techniques. Many laboratories still rely upon the use of a rotary evaporator to perform the evaporation part of their sample preparation protocol prior to LC-MS or GC-MS analysis. While rotary evaporator methods often give good recoveries, they can only handle a single sample, require continuous monitoring to control the process and to ensure that no foaming or bumping occurs. For labs involved with GC-MS or LC-MS – Genevac SampleGenie™ technology in conjunction with a Rocket Synergy, HT or EZ-2 series evaporator is enabling large sample volumes to be dried directly into vials eliminating several time-consuming sample handling steps and the attendant risk of errors. SampleGenie is proven to reduce evaporation times by up to 66%, is compatible with a wide range of HPLC, GC and storage vial sizes and is a proven methodology for environmental analysis, metabolism and toxicology studies, food and beverage research, drugs of abuse testing as well as post purification protocols in life science research.


Environmental analysis of persistent organic pollutants (POPs), glyphosphates and agal toxins are today a critical requirement in monitoring the quality of municipal water supplies. A paper is available for download that describes how a direct evaporative method developed to replace a solid phase extraction sample preparation technique that has traditionally been used prior to LC-MS-MS analysis of algal toxins in lake water. The authors demonstrate how the direct evaporation sample preparation technique offers distinct advantages over solid phase extraction by eliminating the sample clean-up step, improving reproducibility, decreasing analysis time, minimising waste generation and being more cost effective.


MALDI-TOF Mass Spectrometry is a widely accepted technique for the elucidation and quantitation of biomolecules in life science research. However concentrating oligonucleotides, proteins, antibodies and other large biomolecules prior to analysis is not straightforward. A paper is available for download that describes how Genevac centrifugal evaporators have been able to protect these sensitive samples from thermal degradation and by preventing cross contamination between different samples in a microplate.


To review and download the ‘Evaporative Sample Preparation for Mass Spectrometry’ papers please visit www.evaporatorinfo.com/info24.html. 43212pr@reply-direct.com


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