8


Thursday morning started with two parallel sessions. Session 7 – Ion Mobility (I)


Chair: Perdita Barran


Valerie Gabelica - Keynote: What nucleic acids studies taught us about ion mobility spectrometry Fundamentals.


Nick Tomczy - Applying the expanding high resolution (Drift)- Time and (CCS)- Space dimensions.


Richard Blankley - Higher Order Structure of Intact Proteins by Capillary Electrophoresis Native Ion Mobility Mass Spectrometry.


Shazia Khan - Sensitive detection and separation of steroid isomers following derivatisation using Ion Mobility.


Session 8 – Clinical & Forensic Analysis using MS


Chair: Andrew Davison


Brian Keevil - Keynote: LC-MS/MS of steroids in the clinical laboratory.


Danielle Moncrieffe - Quantifi cation of P-III-NP in humans: meeting the challenge.


M. Zubair Israr - Prognostic role of molecular forms of B-type natriuretic peptide in cardiovascular disease.


Ashley Sage - Sensitive and Specifi c Allergen Screening Analysis Using LC-MS/MS.


These sessions were followed by a one-hour coffee break, which was held in the exhibition area.


The pair of Thursday morning parallel sessions continued after the coffee break - before breaking for lunch at 12:30 with sessions on:


Session 9 – Ion Mobility (II) Chair: Frank Sobot


Kostas Thalassinos - Keynote: Ion mobility Mass Spectrometry Studies of Alpha1-Antitrypsin Variants.


Vincen Wu - The exclusion of contaminants from tissue samples using DESI Ion Mobility imaging.


Lucy Woods - The Next Generation Ion Mobility Separation (IMS) Adds A New Dimension to Substance Characterization and Identifi cation.


Rian L. Griffi ths - Native LESA mass spectrometry for direct analysis of proteins and their complexes: Imaging, ion mobility and protein-ligand binding.


Session 10 - Mass Spectrometry in Medicine


Chair: Zoltan Takas


Isabelle Fournier - Keynote: Amazing Spidermass: Tracing the Future of Intraoperative Diagnosis.


James S. O. McCullagh - Biomarker discovery using ion chromatography - mass spectrometry (IC-MS): Signifi cantly elevated 2-hydroxyglutarate in the plasma of IDH+ patients with intrahepatic cholangiocarcinoma (ICC).


Menelaos Tzafetas - iKnife – REIMS and its use as an intraoperative technique for real time tissue identifi cation of cervical disease.


Boakye Gyimah - Mass Spectrometry analysis of omega-3 polyunsaturated fatty acids in biological samples after dietary supplementation.


A break of one hour for lunch, during which the BMSS Annual General Meeting took place, preceded the afternoon sessions, the BMSS Chairs Plenary Lecture, prize presentations and the closing farewell.


Session 11 – (Bio)Pharma Chair: Rachel Garlish


Vojtech Franc - Keynote: All-inclusive proteoform profi ling of human serum glycoproteins by hybrid mass spectrometry approaches.


Tony Bristow - The development of MALDI-TOF-MS techniques for the characterisation of dendrimer drug conjugates.


Will Burkitt - Challenges in peptide mapping mass spectrometry of biopharmaceuticals.


Martic Bachman - Sample-per-second metabolome and lipidome profi ling for accelerated drug discovery.


Session 12 – MS in Environmental & Food Analysis


Chair: Gavin O’Connor


Nathalie Gillard - Keynote: Food allergens analysis: contribution of mass spectrometry.


Joanne Connoly - Discrimination of honey of different botanical origins using an untargeted highdefi nition metabolomic workfl ow.


Juergen Wendt - Development of a GC- MS method for the simultaneous screening of target and nontarget contaminants in river water.


Will Kew - Chemical Complexity and Diversity of Scotch Whisky by FTICR MS


The fi nal lecture - the Plenary – BMSS Chair’s Lecture was given by Professor R. Graham Cooks on ‘Accelerated Organic Reactions in Microdroplets and Thin Films: Mechanisms and Scale up of Organic Synthesis by Mass Spectrometry’.


Late Thursday afternoon saw the presentation of various BMSS awards by the BMSS Chair Dr Christine Eckers as part of the closing ceremony.


The prizes that were awarded were as follows:


The Barber Prize, sponsored by Agilent, was awarded to the best new and upcoming researcher’s oral presentation at the 2017 meeting in honour of Mickey Barber who had a dislike of giving oral presentations. This year’s awardee was Danielle Moncrieffe of the Analytical and Environmental Sciences Division, King’s Forensics, King’s College London for her Thursday morning oral presentation titled ‘Quantifi cation of P-III-NP in humans: meeting the challenge’ which discussed how Procollagen III amino terminal propeptide (P-III-NP) a circulating bone marker present in human blood at low concentrations is used clinically to help diagnose liver damage and as a biomarker in anti-doping.


The Bordoli Prize, sponsored by Waters in honour of Bob Bordoli is awarded to the best new and upcoming researcher’s poster presentation at the 2017 meeting. This year’s awardee was Rani Moons from the Biomolecular and Analytical Mass Spectrometry group, University of Antwerp for her poster titled ‘Bridging the gap between molecular properties and aggregate morphology of IDPs in the presence of small molecules’ which described how using ion mobility-mass spectrometry the group followed the gas phase structural changes of human α-synuclein (AS) under different solution phase conditions. They also developed new methodologies for linking the molecular studies of AS individual subunits properties with the AS aggregate morphology produced under different conditions.


Entrants for these two prizes must be current BMSS members with less than 5 years’ experience in mass spectrometry, including MS oriented PG research but not including career breaks.


The Delegates’ Choice Poster Prize Competition, sponsored by Sciex, provided an opportunity for all delegates of the BMSS Annual Meeting and Conference to vote for their choice as the best poster at the conference from any author.


The Delegates Choice Poster Prize, was awarded to David Romero Perez from the Department of Electrical Engineering & Electronics, University of Liverpool for his poster titled ‘Comparison of Paper Cutting Methods for Paper Spray Mass Spectrometry’ where he discussed the use of paper spray (PS) ionisation in mass spectrometry and how this typically requires a small paper triangle to be cut, which can lead to human error in the size. Alternative cutting methods laser and automatic blade cutting, were compared to manual cutting and dual wax-printed paper triangles. Automated blade cutting was favoured since consistent geometry was achieved in line with the laser method but without the capital equipment cost.


This extremely valuable meeting covered everything from basic principles to fundamental aspects, method developments and applications of the various uses and analyses performed utilising mass spectrometry. The quality of the poster contributions and the novelty of the scientifi c content of the presentations, describing all aspects of mass spectrometry and associated separation techniques, were of tremendous value for both novices and experts.


At the social level, the meeting provided plentiful opportunities to chat and share, over coffee or the inevitable beer. Many of the delegates (~200) attended the Conference Dinner, and thoroughly enjoyed themselves in true BMSS tradition. The vendor exhibition was, as always, a critical component of the meeting for vendors and delegates alike.


The next BMSS annual meeting and conference, its 39th, will held at the Churchill College, Cambridge, Storey’s Way, Cambridge, CB3 0DS and will take place between 10th and 13th September 2018.


Updated details may be found at www.bmss.org.uk


Acknowledgement: Thank you to Lisa Sage, BMSS administrator, for her assistance in providing the awardee information.


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