Laboratory Products Focus
OTHER ASPECTS TO BE CONSIDERED:
Secondary Safety Barriers
When handling pathogenic agents, the design of the laboratory is obviously an important factor to be taken into account according to the biohazard level in question. This refers to secondary protection barriers. This type of barrier is intended to provide the required level of separation between lab areas and public-access areas, as well as to contain the suitable decontamination equipment.
Laboratories can be classified as follows according to their design characteristics, construction and containment barriers:
• Basic laboratory covering levels P1 and P2;
• Containment laboratory corresponding to level P3; and
• Maximum containment laboratory corresponding to level P4.
Given the characteristics of the microorganisms handled in the P4 containment laboratories, which require highly specialised facilities and personnel, few sites around the world have maximum-containment facilities. Laboratory managers are faced with common problems during the design
and construction of P3 containment laboratories.
In a laboratory with biological safety P3, in addition to good laboratory practices and procedures (GLP), care should be taken to ensure the correct design and construction of the facilities, paying special attention to the installation of all the containment barriers of the P3 integrated design. The aim of the above is to ensure that the biological barrier that maintains the safety of the worker and the environment and the containment of the unit are not broken at any time, guaranteeing the quality of the facilities and equipment.
Tertiary and Quaternary Safety Barriers
We speak of tertiary barriers when the actual building requires a special design, or even of quaternary barriers, which relate to the location of the building, for example in areas that are isolated from urban centers.
CONCLUSIONS
Work with pathogenic germs, unknown high-risk microorganisms or cytostatic/cytotoxic drugs has forced R&D labs, hospitals and the pharmaceutical industry to work under
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Circle no. 348
Interested in publishing a Technical Article?
Contact Gwyneth Astles on +44 (0)1727 855574 or email:
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increasingly strict safety conditions to guarantee the protection of their personnel and the environment. These bodies have defined increasingly widespread, global protocols for assessing and preventing risks associated with exposure to biological and chemical agents, to avoid contamination due to contact with these agents.
It is important, when selecting biological and chemical protection equipment, to perform a correct assessment of the risk level and to assign it correctly to the various operations of the process, remembering that the best protection is the one that also makes the user's work easier.
BIBLIOGRAPHY:
• Centers for Disease Control and Prevention:
http://www.cdc.gov/
• Presentation: The 1, 2, 3's of Biosafety Levels by CDC:
http://www.cdc.gov/OD/ohs/pdffiles/ bsl123.pdf
• Laboratory biosafety manual. Third edition. World Health Organization. Geneva 2004:
http://whqlibdoc.who.int/publication s/2004/9241546506.pdf
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