12 New Extensive Range of LC Accessories
Hichrom has launched an expanded range of LC accessories – offering chromatographers useful products for almost every application.
This wide range of products includes high temperature and high pressure fittings, PEEK and stainless steel tubing, standard fingertight connectors, pre-column and inlet filters, microflow fittings and column couplers as well as Rheodyne injector parts and spares – all at an introductory discount of 25% for a limited time.
Hichrom also offer a free technical help desk, manned by experienced chromatographers, who will help you specify, identify and source the LC accessory that you need for your application. The help desk can be contacted on +44(0) 118 930 3660 or by email at:
technical@hichrom.co.uk
Circle no. 322 Improved Cation Separation
Metrohm presents the Metrosep C 4, a new cation column with outstanding separation characteristics. The Metrosep C 4 is the result of latest advances in synthesis procedures and production processes and has even better separation characteristics than its predecessors, the Metrosep C 2 and Metrosep Cation 1- 2 column types. The Metrosep C 4 column has a clearly improved peak shape which leads to a better separation of the individual peaks. Direct comparison has revealed that using the Metrosep C 4 the number of theoretical plates per meter is higher than that obtained on the Metrosep C 2 or Cation 1-2 columns. Additionally, for standard cations, transition metals and amines, the Metrosep C 4 column shows better results with regard to peak shape, peak height, resolution and asymmetry factor. Especially for monovalent cations, the C 4 column achieves a very high number of theoretical plates per meter, thus yielding outstanding detection limits and an improved separation of sodium and ammonium.
Circle no. 323
Chromatography Data System Software Enhancements The ChromSword®
Recent work published by experts from Viscotek, a Malvern company, showcases the TDAmax gel permeation/size exclusion chromatography (GPC/SEC) system as an information-rich, time-efficient analytical solution for the comprehensive character- isation of complex food ingredients and additives based on polysaccharides. The Viscotek TDAmax sets the benchmark for GPC/SEC, with a fully integrated triple detector array that includes a revolutionary low angle light scattering detector (LALS), four capillary differential viscometer and refractive index detector. The work by Dr Gerhard Heinzmann and Dr Bernd Tartsch is detailed in a paper ‘Alginates, Chitosanes and Xanthans – Characterisation of Food Ingredients by GPC/SEC with Triple Detection’, published in AgroFOOD Industry Hi-tech (Vol 20 No. 4, 2009).
Development interface for its ChromSwordAuto® product and the Dionex Chromeleon®
Group is pleased to announce the release of a new Automated Method CDS
software. This new interface was developed in cooperation with Dionex Corporation and allows combining Dionex UltiMate®
3000 instruments with powerful tools for method development offered
by ChromSword. The new solution uses Chromeleon software to control the instrument and sequence data and optimised instrument methods are stored in the Chromeleon database for later use. The ChromSwordAuto interface features include automatic search for optimal separation conditions including column switching, solvent selection, and gradient optimisation. The options are set in the ChromSwordAuto interface and automatically transferred to Chromeleon software.
“The new solution makes method development a lot easier, especially when combined with the column and solvent switching capabilities of the UltiMate 3000 HPLC product line,” said Andreas Brunner, Product Manager, Chromatography Software, LSBU Dionex. Dr Sergey Galushko, Head of the ChromSword Group development team, stated: “Chromeleon and ChromSwordAuto are very powerful software systems. The combination of ChromSwordAuto intelligent method development tools with Chromeleon flexible instrument control functionalities will provide a major benefit to our customers. Using ChromSwordAuto and Chromeleon in tandem allows a chromatographer to run all method development tasks fully automatically: this includes method scouting, impurity profiling, fine optimisations, and robustness tests. I am confident that this combination will substantially reduce method development time for Chromeleon and ChromSwordAuto users.” The ChromSword Group is an organisation of international scientists, analytical and physical chemists, mathematicians and programmers dedicated to the automation of chromatographic method development and validation processes. ChromSword products are used worldwide for computer-assisted and fully automatic method development.
Circle no. 324
Using GPC/SEC, passing a sample through a series of carefully specified packed columns separates it on the basis of hydrodynamic size. Single or multiple detectors analyse the resulting fractions. The design and selection of the detectors dictates how much information can be gathered during each experiment. The TDAmax detector array provides absolute molecular weight without extrapolation or correction, molecular size, and intrinsic viscosity, as well as information on structure, conformation, aggregation and branching. Adding an additional UV/Vis detector, creates an integrated tetra detector array ideal for copolymer characterisation.
The performance characteristics of a range of food ingredients depend on their molecular weight and structure. It is also possible that low molecular weight fractions in some ingredients may even be harmful to human health. It is important therefore to confirm that these have been removed. Many food ingredients have large molecular sizes, however, and this can present a challenge in accurately determining molecular weight distribution. The research detailed in the paper shows that the TDAmax can meet this analytical challenge and that it provides accurate and detailed information.
Circle no. 325
CHROMATOGRAPHY & SPECTROSCOPY
Accurate Characterisation of Complex Biopolymers
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