31 Delivering Enhanced Functionality to Guide Decisions in All Stages of Drug Discovery
Optibrium launches StarDrop 5.1, an upgraded version of its innovative support tool that helps drug discovery scientists to guide key decisions in drug discovery and quickly achieve successful project outcomes. As a result of this upgrade, StarDrop’s unique capabilities to guide the design and selection of high quality, novel compounds are now available on the Apple Mac, a reflection of the increasing popularity of Macs within the industry. The revolutionary StarDrop 5.1 is a powerful yet user friendly software package which combines predictive capabilities with intuitive approaches to quickly and confidently target compounds with a good balance of properties, thereby reducing wasted effort and speeding progress to identify effective lead and candidate drugs. StarDrop’s unique approach to ‘multi-parameter optimisation’ explicitly accounts for the uncertainty in drug discovery data, whether due to experimental variability or predictive error, to provide scientists with a rigorous, objective analysis on which to make rational decisions. As well as compatibility with the Apple Mac, StarDrop 5.1 brings a number of significant enhancements to existing features of StarDrop. For example, there is a new method for creating ‘chemical space’ visualisations based on the latest machine learning algorithm for ‘visual clustering’, that helps to easily explore the diversity of a project’s chemistry and identify ‘hot spots’ of high quality chemistry for further investigation.
There are also improvements to StarDrop’s plug-in modules: The Auto-Modeller™ sees the addition of the ‘Random Forests’ technique to its extensive repertoire for building predictive models tailored to a project’s chemistry and data. The addition of this new method has also led to improved QSAR models in the ADME QSAR module, which provides predictions of key ADME properties. StarDrop’s P450 metabolism module has been upgraded to provide improved prediction of regioselectivity and lability of metabolism by Cytochrome P450 enzymes, specifically around N-oxidation pathways. Finally, in response to user feedback on the new Nova™ module, further advances allow the generation of novel, relevant compounds ideas, prioritised against a project’s required property profile, starting from multiple initial structures and filtered according to user-specified rules to avoid unwanted substructures.
Circle no. 423 New High-Intensity LED Light Transilluminator
Syngene is delighted to introduce the UltraSlim-LED blue light transilluminator, a high-intensity LED light transilluminator, which allows scientists safe, sensitive viewing of a wide range of fluorescently stained DNA/RNA gels. The compact UltraSlim-LED transilluminator uses LEDs to produce an Epi-blue light with a narrow emission peak centred at 470nm. This is not only safer but is comparable to UV for the excitation of most fluorescent dyes, including Ethidium bromide, GelRed, GelGreen, SYBR Gold, SYBR Green, SYBRSafe, and Syngene’s new UltraPower DNA safe dye. The UltraSlim-LED can be used as a portable transilluminator on the bench as the system is easy to lift, takes up very little bench space and scientists do not have to worry about stray UV light causing retinal and skin damage. The transilluminator is also compatible with any Syngene gel documentation system, allowing users to produce high quality images for publication or analysis. The transilluminator features a special built-in glass filter lid, providing optimum viewing conditions for band cutting. Additionally, since LED illumination is not as damaging to DNA as UV, even after long exposure times, scientists could improve the cloning efficiency of DNA fragments they extract from gels viewed on an UltraSlim-LED transilluminator.
Laura Sullivan, Syngene’s Divisional Manager, stated: “Isolating DNA is probably among the most basic things molecular biologists regularly do and we are pleased to introduce our UltraSlim-LED illuminator as it offers a way of safely viewing stained gels, either on the lab bench or inside a gel doc system.” Laura concluded: “Using high-intensity blue light eliminates the dangers of using UV, does not damage DNA fragments and yet illuminates even the faintest of bands. This makes the UltraSlim-LED transilluminator an essential purchase for molecular biologists wanting safe, effective imaging of their fluorescent gels.”
Circle no. 424 ADVERTORIAL
Thermo Scientific NESLAB Recirculating Chillers Provide Years of Worry-Free Operation
C and cooling capacities up to 20000 watts. Designed as a modular platform, the ThermoFlex line offers a wide variety of options and cooling capacities that can be configured for diverse applications in markets such as analytical, biotech, optical, medical, microscopy, laboratory, laser, metrology, and pharmaceutical. Each chiller includes air and water filters that can be changed while the unit is in operation and an intuitive user interface for ease of operation. End-users benefit from innovative, patented packaging for rapid installation and a quick start guide for seamless start-up in minutes. User-adjustable alarms protect your application. An extended temperature range of +5o
The Thermo Scientific NESLAB ThermoFlex recirculating chiller platform was developed with customer input from concept to design. The result is an easy-to-use, easy-to-maintain high performance chiller platform configurable to the most demanding applications. The ThermoFlex chillers maintain process temperatures from +5o 0.1o
C to +40o C with stability of +/- C to +90o C to +35o C with stability of +/-0.1o C. For more information, visit
www.thermo.com/thermoflex Your success
circulates C is available as well as a deluxe controller option which offers a Multi-line LCD Display.
Thermo Scientific also provides the Merlin Low-Range Recirculating Chiller series for process temperature from -15o
Circle no. 425
Thermo Scientific temperature control systems deliver the perfect fit: reliable and accurate heating and cooling for virtually any application. From immersion circulators and refrigerated/heated bath circulators to chillers and heat exchangers – our solutions deliver the precise temperatures and expertise you require. So when temperature control means everything, it’s easy to keep your cool.
at every degree • Visit
www.thermoscientific.com/tc for more information
General Laboratory Application Refrigerated/ Heated Circulators
The newest Thermo Scientific thermostat line is designed as the perfect fit for many applications in the lab from -50 to +300°C. The HAAKE Arctic refrigerated baths and HAAKE Sahara heated baths can be combined with three performance types of control heads, the HAAKE Standard, Advanced and Premium heads, building versatile temperature control systems for various open bath applications (beakers, racks, probes), or precise cooling and heating of photometers, rheometers, electrophoresis or other lab equipment.
A key focus of the thermostat design was the intuitive user controls and an energy saving feature for all refrigeration systems. The control head can be oriented to all four sides on the bath giving great flexibility for the setup in the lab.
All systems are UL/CSA & CE compliant and manufactured in superior quality which is underlined by 3-years warranty and supported worldwide by Thermo Scientific.
For more information, visit
www.thermo.com/bathad
•Compact design • Built-in energy-saving feature •Up to 500 watts of cooling
Visit
www.thermoscientific.com/polar to download our new product brochure.
Circle no. 426 Circle no. 427
NEW! Thermo Scientific ThermoPolar Recirculating Chiller
Perfect for your closed or open-loop application
LAB ASIA - NOVEMBER/DECEMBER 2011 - LABORATORY PRODUCTS
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