13
Laboratory Boosts Capacity and Efficiency with Chromatography Software
Waters Corporation announced that its customer Advantar Laboratories, Inc has successfully completed its rollout of Waters®
Empower™ 3 Chromatography Software. The 21CFR Part 11
compliant-ready software will play a key role at Advantar and with its new Method Remediation Services group to meet increased demand by pharmaceutical and contract manufacturing customers for converting legacy HPLC methods to Ultra Performance LC® which offer greater speed, resolution and sensitivity.
(UPLC® ) methods,
Advantar selected Empower 3 software to control its expanding portfolio of gas chromatography (GC), high performance liquid chromatography (HPLC) and UPLC systems with advanced detectors including Waters single and tandem quadrupole mass spectrometry (MS/MS), photodiode array and ultraviolet detectors. Waters Empower 3 chromatography software bridges the various technologies at Advantar and enables the company to scale its analytical lab resources efficiently.
“Our decision to go with Waters was driven by several key factors including requests from customers. By adding UPLC technology to our lab and creating the Method Remediation Services group, we can support clients who need to develop a UPLC method or rapidly convert multiple methods from HPLC to UPLC simultaneously for large and small molecules alike,” said Advantar Vice President of Sales and Marketing, Brandon Griffin.
“We strongly believe UPLC is the future of chromatography because it greatly reduces run times and solvent waste while significantly improving peak resolution, sensitivity and speed. These benefits translate into tremendous environmental, time and material cost savings for laboratories,” said Rohit Khanna, PhD, Vice President of Worldwide Marketing, Waters Division. ”For our global base of clients, our UPLC technology continues to support their product development and manufacturing efforts.”
Advantar is now well-equipped to support pharmaceutical companies and contract manufacturers of proprietary and/or off-patent drug products, by leveraging UPLC technology to enhance quality systems for time-critical release testing as well as method development/method transfer needs.
Circle no. 336 Simplifying Entangled Polymer Synthesis
At the University of Houston, USA, researchers have recently developed and verified a new route for synthesising superior forms of entangled or knotted polymers with pre-designed characteristics for use in applications such as drug delivery and smart coatings. Using a Viscotek 270max triple detector gel permeation chromatography (GPC) system from Malvern Instruments, the Houston team successfully confirmed the innovative synthesis of interlocking polymer rings (catenanes) by atom transfer radical polymerisation (ATRP) from templated initiators. By combining refractive index (RI), viscosity and light scattering detection, the 270max provides reliable molecular weight data and easy detection of the degree of synthesis throughout the method development, as well as verifying the character of final polymers imaged using atomic force microscopy (AFM).
“The Viscotek 270max is critical to verifying this new method of polymerisation,” explained Professor Rigoberto Advincula, Department of Chemistry, University of Houston. “These are high molecular weight polymers and ring closure is a thermodynamically difficult reaction that must be done under dilute conditions. Using the triple detection offered by 270max, we were able to effectively characterise the molecular weight of our sample and detect the degree of ring closure versus the amount of non-closed polymer.”
The University of Houston’s initial success implies that it will be possible to synthesise superior knotted polymers for applications in coatings, lubricants and surface modifiers, among others. In terms of polymer theory, Professor Advincula’s team also plans to make catenated and knotted block co- polymers. The project has been funded by the National Science Foundation (USA). A paper outlining the new method is being published in Chemical Communication from the Royal Society of Chemistry and is now available online.
The Viscotek 270max from Malvern Instruments is a complete, advanced, multidetector GPC/SEC system suitable for all macromolecular applications, particularly research.
Circle no. 337 ADVERTORIAL Sonimix 2106 Gas Divider
The sonimix 2106 is the ideal product to mix and dilute high concentrated gas cylinders. Using the technology of sonic nozzles, this device will give the best accuracy (0.5% relative) and repeatability (0.2% relative) on the market. The range of the device goes from a 10 dilutions steps up to a 1024 dilutions steps. The sonimix 2106 line is the best product for the linearisation of gas analysers and sensors. Available options: compatibility with corrosive gases, RS 232, remote command, ISO 17025 calibration certificate, GasCal software.
Circle no. 338 Hydrogen Generators
LNI Schmidlin SA has developed two different types of hydrogen generators. PG-H2 and NM-H2 series are ATEX certified and have capabilities for cascading.
Both models employ’s the newest membrane technology available and includes the exclusive no maintenance auto drying technology. The pure gas (99.9999%) is ideal for operation with gas analysers, as fuel gas for flame tools, all kind of carrier gas application, like GC and GC-MS (mass spectrometry) and as safe source of pure hadrogen in plasma chambers and other isolated environments.
Circle no. 339 Whisper Nitrogen Generator
The Whisper nitrogen generator has been developed using the menbrane technology to meet the specific requirements in terms of flow, purity and pressure in LC-MS applications. It can also be used for the evaporation of solvents in samples being analysed. The model exists in different flow rates, with or without internal compressor. A specific model called Whisper Hybrid has been specially designed for ABI LC-MS applications.
Air Generators Circle no. 340
Three versions are available: • Air Station: includes a quite built-in air compressor for to supply oil free and dry air. • GC / Zero Air Station: includes (for the station) a built-in compressor for to supply oil free and dry air. A catalytic oven removes the hydrocabons down to 0.1 ppm. • GT / Ultra Zero Air Station: includes (for the station) a built-in compressor for to supply oil free and dry air. A catalytic oven removes the hydrocabons down to 0.1 ppm and in
addition a set of specific PSA filters to remove the CO2, CO, HC, NOx, SO2 and O3 contaminants and moisture down to 0.1 ppm.
Typical flow rates for the instruments are from 1.5 L/min to 30L/min. The uses of air generators reduce the operating costs significantly.
Circle no. 341 Circle no. 342
LAB ASIA - NOVEMBER/DECEMBER 2011 - CHROMATOGRAPHY
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44
