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by his own admission off topic and had no real relevance to hyphenated techniques. He was followed by Janusz Pawliszyn (CA) whose topic was ‘SPME for on-site and lab quantification in complex systems – advantages and limitations’ and then by Valerie Pichon (FR) who talked about ‘Biological and biomimetic approach for selective sample pretreatmen’. These plenary lectures were in a session titled Novel techniques and materials for sample preparation and separation which was chaired by Hernan Cortes.


After a short break the day resumed with a session on sorptive sampling techniques chaired by Valerie Pichon. Speakers in this session included Patrick Dirinck (BE) who talked on ‘GC-MS and mass fingerprinting for understanding and measuring aroma characteristics in food products’, discussing how the use of GC-MS was superior to the technique of GC–Olfactory detection and answered questions such as ‘why do my food, orange juice and wine taste different’ and the growing use of mass fingerprinting in determining flavours and odours in foodstuffs. Roland Meesters (CO) followed with a talk on the ‘Evaluation of peripheral blood microsampling techniques in combination with LC-HRMS for drug pharmacokinetics in clinical studies’.


A break for lunch and ample time to review posters and the exhibits were followed in the afternoon with sessions on ‘Advances in sample prep and hyphenation’ chaired by Alois Jungbauer and ‘life-science and biological samples’ chaired by Janus Pawliszyn.


Keynote lectures by Nobuo Ochiai (JP) – ‘Multi-stir bar sorptive extraction (SBSE): a new approach for SBSE using non-polar and polar coatings’ which really was a commercial presentation dressed up to be a keynote lecture and Monika Wortberg (DE) ‘Use of laboratory chromatographs as online instruments for waste water monitoring’ who showed how BASF in Germany deal with waste water treatment by using online Full Evaporation Headspace Gas Chromatography (FE-HSGC) as a monitoring tool.


Oral presentations followed by:


• Audrey Combes (FR), a student of Valerie Pichon discussed the ‘Synthesis and evaluation of a MIP for selective extraction of β-methylamino-L-alanine’.


• Beate Gruber (DE) discussed ‘Needle trap microextraction combined with GCxGC-


TOF for the analysis of breath gas’ .


• Krzysztof Gorynski (CA) ‘Development of SPME-LC-MS method: application to pharmakinetic study’.


• A tutorial session given by Tuulia Hyotylainen (FI), the HTC-12 award recipient, on ‘Sample preparation for metabolomics and for biological samples’.


Oral presentations followed by Stig Pedersen-Bjergaard (NO) talking about ‘“Liquid-phase microextraction – Implementation in micro-chips and 96-well technology’, whose presentation focused on the very recent development of Parallel Artificial Liquid Membrane Extraction (PALME) [4]. PALME is a modification of hollow fibre liquid-phase microextraction (HF-LPME) where the hollow fibres are replaced by flat membranes in a commercially available 96-well plate sandwich format. Benjamin L’homme (BE) gave the last oral presentation of the day on ‘Analysis of Persistent Organic Pollutants in 20 µL blood by MEPS-GC-MS/MS’ looking at the isolation and quantitation of the ‘Dirty Dozen’ pollutants listed by the Stockholm Convention.


This was followed by a novel concept introduced for the first time – Flash Posters - where a poster can be presented in a 5 minute time slot to a wider audience in a lecture theatre setting.


Taking place in parallel during the first day of HTSP-3 were the two short HTC courses with titles of ‘Mass spectrometry: fundamental developments and hyphenation strategies’ with Professor E. De Pauw (ULiege) as the instructor and ‘Strategies for efficient hyphenations of (U)HPLC with MS’ Instructed by Dr G. Rozing


Starting the second day the aims of the three day HTC-13 meeting were to ‘cover all fundamental aspects, instrumental developments and applications of hyphenated chromatographic techniques’. These include hyphenation between chromatography and detection systems (with a focus on mass spectrometry), multi- column (multi-dimensional) chromatography, and the coupling between sample- preparation and separation techniques. Many aspects of chromatography were addressed, including automation and the use of robots, miniaturisation and microfabricated analytical devices, high- pressure and high-temperature LC, and new detection techniques.


HTC-13 covered many innovative applications based on hyphenated


techniques, taking place in 3 parallel sessions which for at least the Wednesday included HTSP-3 in parallel, making it difficult and a little frustrating attempting to participate in the multitude of interesting discussions.


This review will now focus on a selection of the presentations given during the HTC-13 meeting. However an overview of the main topics covered during the symposium is given here:


• Fundamental strategies for the hyphenation of contemporary chromatographic and other separation techniques with sample preparation and advanced detection systems.


• Emerging detection strategies compatible with current separation techniques.


• The marriage of hyphenated techniques with process analytical technology.


• New developments in column technology.


• Applications in life sciences, including pharmaceutical analysis, biosystems research, and bio-analysis.


• Relevance in food science, including the analysis of contaminants and residues.


• Environmental science. • Clinical and forensic applications.


• Combination with chemometrics and data-analysis.


• Applications in the chemical and petrochemical industry.


• Hyphenated techniques for natural products, flavours and fragrance analysis.


• Applicability in ‘omics’ (metabolomics, proteomics, lipidomics, etc.).


• Hyphenated techniques and polymers analysis.


The opening session of HTC-13 chaired by Hernan Cortes, Pat Sandra and Freddy Adams consisted of two plenary lectures, first Gert Desmet (BE) discussed the ‘Instrument influences on observed column performance’ and expressed the opinion that instrumentation needs to change from the ‘hifi tower’ construction of today to an injection-column-detection system which has no interconnecting tubing. Hans-Gerd Janssen (NL) then discussed ‘From good multi-dimensional data to great multi- dimensional information’.


The closing of this session on the Wednesday, saw a lifetime-achievement- award presented to Milton Lee from the Department of Chemistry and Biochemistry, Brigham Young University, Provo, USA. The


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