11 Detection of Nitrosamines in Food & Drink
Nitrosamines are highly toxic compounds that can enter the body through consumption of food and drink. It is important that levels nitrosamines in food and drink are accurately monitored as many cancers have been attributed to the exposure of nitrosamines or nitrosamine forming compounds.
Chemicals such as sodium nitrite and sodium chloride are often added to help cure and preserve food. The presence of amines already found in the food in combination with these chemicals can form nitrosamines compounds.
In Brewing Barley undergoes a malting process, the grain if first drenched to make it germinate and then dried in
kilns to capture the sugar and flavour compounds for the brewing process. The Heating in the kilns can cause the formation of carcinogenic nitrosamine compounds in the grain, these can then potentially be passed on to the final brewed product. It is therefore essential that any malt used in brewing is checked for nitrosamine levels.
The 800 Series from Ellutia Thermal Energy Analyser (TEA) has been an industry standard for nitrosamine analysis since its introduction thanks to its simple operation, low limits of detection, almost infinite selectivity for nitrogen containing compounds, and considerably lower cost than expensive GC-MS/MS systems. The 800 Series TEA can be interfaced with most common GCs.
For further information visit
www.ellutia.com.
Sensitive and Simple Determination of
Monochloroacetic Acid in Carbocisteine
Thermo Fisher Scientific has developed a reproducible and accurate ion chromatography (IC) method for determining monochloroacetic acid (MCAA) in carbocisteine drug substance and two carbocisteine drug products, thus enabling efficient quality control of the carbocisteine manufacturing process. Application Note 1076: Determination of Monochloroacetic Acid in Carbocisteine demonstrates that this IC method is easily executed using a reagent-free IC system controlled by data management software. The analyst simply adds water and samples to separate and accurately determine MCAA using a hydroxide-selective anion-exchange column (Thermo Scientific™ Dionex™ IonPac™ AS11-HC column).
Carbocisteine is a mucolytic drug frequently prescribed to improve the breathing of patients with chronic bronchitis and bronchial asthma. During the carbocisteine production process, the substrate MCAA—which is cardio- and hematotoxic—is used and is inevitably present in the carbocisteine drug substance and hence products. Therefore, the determination of MCAA is important for the quality control of carbocisteine production. This new approach is sensitive and easier to use than other commonly used methods available to date.
For more information visit
www.thermofisher.com
● Ultra-inert solid-core UHPLC / HPLC columns ● High efficiency 2.5µm and 5µm solid-core particles
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ACE, UltraCore, SuperC18 and SuperPhenylHexyl are trademarks of Advanced Chromatography Technologies Ltd
• New in 2014, we are proud to be UK and Ireland distributors for OI Analytical GC products
• Eclipse 4660 Purge and Trap for the ultimate in low level volatile analysis
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Contact us or see our website for more details, sales or service.
Web:
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info@davidsonanalytical.co.uk Tel: 0115 9814716
ACE UltraCore ®
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All the proven advantages of ACE UHPLC / HPLC columns… …now available with solid-core particles
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