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September 2009
PerkinElmer Awarded U.S. Patent on Method to Ensure Accuracy of Automated
Thermal Desorption Gas Chromatography “In the past, analysts had to be concerned that their results could be affected by lack of integrity of the packingmaterials in ATDtubes and traps,” said Tipler. “Our automaticmethod for checking the packaging integrity helps our customersmaintain a high level of confidence in their analytical results, ultimately helping themto save time and increase lab productivity. Themethod is already incorporated in our TurboMatrix ThermalDesorber line, which can be used in a wide range of industries and applications.”
PerkinElmer announce that the U.S. Patent & TrademarkOffice (USPTO) has awarded it PatentNo. 7,422,625 B2 covering an advancedmethod in gas chromatography (GC). The patent, titled “Methods and Systems for Characterizing a Sorbent Tube,” protects the Company’s-proprietary methods that help gas chromatographers increase the accuracy of their results when using automated thermal desorption (ATD) gas chromatography (GC).
PerkinElmer’s automatic verificationmethod described in the patent is deployed in the Company’s TurboMatrix™ThermalDesorber <
http://las.perkinelmer.com/content/RelatedMaterials/Brochures/BRO_T urboMatrixTD.pdf> product line ofGC systems to help users avoid manual errors in ATDmeasurement, which can cause inconsistent results and compromise sample integrity. Themethod was co-invented by Andrew Tipler, senior scientist, gas chromatography, PerkinElmer, and Neil Plant, senior scientist, Health and Safety Laboratory <
http://www.hsl.gov.uk/> , Buxton, United Kingdom.
PerkinElmer first introduced ATDin 1982 as an effectivemethod for isolating volatile compounds fromvarious gaseousmatrices so they can be introduced as samples into aGC instrument. It is themost popular technique for both indoor and outdoor airmonitoring and is also used for analysis of soil, water, biofuels, polymers, packagingmaterials, flavors and fragrances, cosmetics, pharmaceuticals, andmany other applications.
Formore information on PerkinElmer’s TurboMatrix ThermalDesorber product line, please visit
www.perkinelmer.com/turbomatrix
New Core-Shell Column Technology Delivers Ultra-High Performance on any HPLC
Phenomenex Inc. introduces Kinetex – ultra-high performance LC columns based on the company’s new core-shell silica technology. Kinetexmeets researchers’ need to improve results and increase productivity without large capital expenditures. By delivering significant improvements in speed and separation efficiency over traditional 3- and 5-micron columns, Kinetex enables chromatographers to get performance comparable to sub-2-micron columns without investing in UHPLC systems. With Kinetex, researchers can achieve UHPLC results on any LC instrument platform, and any chromatographicmethod can now be completed at a fraction of the time previously required, without sacrificing performance. The increased separation efficiencies of Kinetex also significantly reduce solvent usage andmaintain long column life.
“The revolutionary advantage of Kinetex is that it delivers UHPLC benefits to every chromatographer, raising the bar for all chromatographic methods,” commented FashaMahjoor, CEO and president of Phenomenex. “This is especially good news for labs whose reduced budgets cannot accommodate the purchase of an expensive UHPLC instrument. Kinetex alleviates the need for a system upgrade.”
With traditional, fully porous particles, efficiency decreases as flow rate increases, resulting in loss of resolution and sensitivity, which slow the overall analysis time. Kinetex core-shell technology enables high resolution and sensitivity over an extended linear velocity without generating excessive backpressure. These columns provide roughly twice the efficiency of fully porous 3-micron columns and three times the efficiency of fully porous 5-micron columns with significantly lower limits of detection and quantitation.
Initially, Kinetex core-shell columns are available in two particle sizes – 2.6- and 1.7- micron – and three chemistries – C18, PFP and HILIC. Kinetex 2.6-micron columns deliver separation efficiencies that match or exceed the performance of traditional fully porous sub-2-micron columns. The Kinetex 1.7-micron is the first ever sub-2-micron core- shell technology and delivers efficiency gains of 15 to 20 percent over traditional fully porous sub-2-micron columns.
Method transfer challenges, common with traditional sub-2-micron products, are eliminated with Kinetex. Methods developed with either 2.6- or 1.7-micron Kinetex columns are scalable and can be transferred to any LC system using the 2.6-micron column, regardless of the instrument’s pressure capability.
“Phenomenex’s proprietary synthesis process produces themost homogenous porous shell and spherical particle ever offered,” said EmmetWelch, seniormanager of product development. “Over the past three years, our teamof sol-gel scientists, organic chemists and production engineers has realized some remarkable achievements in core-shell technology. This technology will forma solid foundation for the future high-performance liquid chromatography columns.”
In food safety applications such as the detection of carbamate pesticides, antibiotics, aflatoxins or azo dyes, Kinetex enables better resolution of more complexmixtures in less time. The same is true for important environmental analyses such as detection of explosives, carbamate pesticides and chlorinated herbicides. In drug discovery research and toxicology studies, the speed of Kinetex analysis can reduce development time on therapeutics such as tricyclic antidepressants, sulfa drugs, beta-blockers, ranitidine and cough and coldmedicines. Kinetex also delivers superior separations for forensic toxicology applications such as the detection of opiates and other illicit drugs.
Phenomenex application scientists and support personnel will help customers increase their return on HPLC instrument investments by assisting in the conversion of analytical methods developed on traditional 3- and 5-micron columns to Kinetex technology. Applications specialists are also trained and ready to assist ultra-high pressure users in the switch from traditional sub-2-micron columns to Kinetex, as well as with moving methods from one system platform to the other. For more information visit
www.phenomenex.com.
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