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personnel should be aware of its possibility whenever a MBL- producing Enterobacteriaceae outbreak occurs.


Supplementary materials. To view supplementary material for this article, please visit https://doi.org/10.1017/ice.2018.331


Acknowledgments. We thank Dr Isao Miyairi, Mie Sugawara, Dr Ken Hori, Dr Naoya Fukushima, and Dr Masaru Miura for their cooperation and advice in our outbreak investigation and James R. Valera for his assistance in editing the manuscript.


Financial support. No financial support was provided relevant to this article.


Conflicts of interest. All authors report no conflicts of interest relevant to this article.


References


1. Magiorakos AP, Suetens C, Monnet DL, Gagliotti C, Heuer OE. The rise of carbapenem resistance in Europe: just the tip of the iceberg? Antimicrob Resist Infect Control 2013;2:6.


2. Suzuki S, Matsui M, Suzuki M, Tsutsui A, Shibayama K. The surveillance report of carbapenem-resistant enterobacteriaeceae infection based on infectious disease law in Japan, 2014. http://www0.nih.go.jp/niid/idsc/iasr/ 35/418j.pdf. Published 2014. Accessed January 26, 2015.


Kenta Ito et al


3. Hayakawa K, Miyoshi-Akiyama T, Kirikae T, et al. Molecular and epidemiological characterization of IMP-type metallo-beta-lactamase- producing Enterobacter cloacae in a large tertiary care hospital in Japan. Antimicrob Agents Chemother 2014;58:3441–3450.


4. Stillwell T, Green M, Barbadora K, et al. Outbreak of KPC-3 producing carbapenem-resistant Klebsiella pneumoniae in a US pediatric hospital. J Pediatr Infect Dis Soc 2015;4:330–338.


5. Laboratory protocol for detection of carbapenem-resistant or carbapene- mase-producing, Klebsiella spp. and E. coli from Rectal Swabs, 2012. Centers for Disease Control and Prevention website. http://www.cdc.gov/ hai/pdfs/labSettings/Klebsiella_or_Ecoli.pdf. Published 2012. Accessed May 7, 2015.


6. Arakawa Y, Shibata N, Shibayama K, et al. Convenient test for screening metallo-beta-lactamase-producing gram-negative bacteria by using thiol compounds. J Clin Microbiol 2000;38:40–43.


7. Liu Y, Li XY, Wan LG, Jiang WY, Li FQ, Yang JH. Molecular characterization of the bla(KPC-2) gene in clinical isolates of carbapenem-resistant Klebsiella pneumoniae from the pediatric wards of a Chinese hospital. Can J Microbiol 2012;58:1167–1173.


8. Benenson S, Warburg G, Hidalgo-Grass C, et al. Comparison of two carbapenem-resistant Klebsiella pneumoniae clones: from a contained outbreak in a paediatric population and from a national epidemic. J Antimicrob Chemother 2012;67:1651–1654.


9. Montagnani C, Prato M, Scolfaro C, et al. Carbapenem-resistant Enterobacteriaceae infections in children: an Italian retrospective multicenter study. Pediatr Infect Dis J 2016;35:862–868.


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