wgs-guided s.pyogenes outbreak control 855


figure 1. Approximately maximum likelihood phylogenetic tree of GAS isolates. A whole-genome phylogenetic tree, removed of mobile genetic elements that are comprised of 43 ward isolates and 24 community isolates was presented here and rooted relative to Streptococcus dysgalactiae (top figure). Grey boxes constitute the members in a given cluster. Symbols within the grey boxes; C1 denote the outbreak cluster, C2 and C3 denote the other 2 nonoutbreak clusters. Numbers in parentheses below the symbols C1–C3 represent minimum– maximum SNP differences between any pair of isolates within the given cluster. Bottom figures C1, C2, and C3 represent refined (recombination regions were further removed by Gubbins) rescaled versions of the relevant clusters shown in the top figure. The scale bars represent nucleotide substitutions per site. Five patients (P1-P5) had repeat S. pyogenes isolates.


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