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Live Cell Imaging


the HT microscope pioneered by Tomocube delivers label-free, real-time images and measurements of cellular structures. When combined with fluorescence imaging, the Tomocube HT-2 microscope delivers HT and fluorescence correlative analysis in 2D, 3D and 4D, and recent work is harnessing arti- ficial intelligence and machine learning to enhance our under- standing of the physiology and pathology of cells and tissues and, possibly, critically contribute to the diagnosis and treat- ment of disease.


Acknowledgments Te author wishes to thank Dr. YongKeun (Paul) Park


and his fellow scientists at the Biomedical Optics Laboratory at KAIST (Korea Advanced Institute of Science & Technology). Dr Park is the Principal Investigator of the Biomedical Optics Laboratory, and its work led directly to the founding of Tomo- cube where he serves as CTO.


References [1] F Von Zernike, Physica 1 (1934) 689–704. [2] YS Kim et al., Yale J Biol Med 91(3) (2018) 267–77. [3] N Lue et al., J Phys Chem A 113(47) (2009) 13327–30. [4] Y Park et al., Opt Express, 14(18) (2006) 8263–68. [5] M Habaza et al., Opt Lett 40(8) (2015) 1881–84. [6] M Schürmann et al., J Biophotonics 11(3) (2018) e2017 00145. [7] K Kim et al., Biomed Opt Express 8(12) (2017) 5688–97. [8] L Moosung et al., bioRxiv https://doi.org/10.1101/539858.


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