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AFM System Demonstrates Multiple Uses at the Korean Research Institute of Chemical Technology (KRICT)


The Korean Research Institute of Chemical Technology (KRICT) has helped drive the growth of the country’s chemical industry. There are four key research fi elds: the development of eco-friendly chemical process technology; the development of high value-added green chemical materials; the discovery of new substances for disease treatment; and fi nally, the development of green convergence chemical technology.


different makes of AFM, she has settled on the JPK NanoWizard®


Dr Yu Jin Jung is a senior research scientist at Research Center for Convergence Nanobiotechnology (RC2NT) of KRICT where her work involves the study of a broad range of biomaterials. The Director of RC2NT is Professor Dr Yung Doug Suh. He is also affi liated as Professor at SungKyunKwan University. Dr Jung has applied a number of microscopy techniques including transmission electron microscopy (TEM) and atomic force microscopy (AFM). Having used a variety of because of its advantages when performing force measurements.


AFM is being applied in many different experiments. These include high resolution imaging of a single biomolecule together with single molecule force spectroscopy (SMFS) and force mapping of polymers: DNA, RNA, proteins, cells, etc. The AFM is also being interfaced with spectroscopy techniques including fl uorescence and Raman to enable chemical mapping and species identifi cation. It will be modifi ed to become a new generation SMTERS (Single Molecule Tip-Enhanced Raman Scattering) platform under the guidance of Professor Suh, one of the co-inventor of TERS in 2000.


Talking about her work, Dr Jung said: “For our imaging work, JPK’s AFM has proved particularly useful for observing the shape, structure, and organisation of DNA oligonucleotides, viruses and cells in buffer solution in real-time. We use it also for our SMFS studies. The NanoWizard AFM enables us to study the interactions of biological systems over scales ranging from single molecule to whole cells. It provides unprecedented possibilities for mapping the distribution of single molecule on the surfaces of cells. Viruses may be studied with nanometer spatial resolution.”


Continuing, she said: “JPK’s AFM is specialised in fi eld of force measurement and force mapping. When the force mapping was performed, several force curves on each pixel in a map was recorded. This function is particularly good for force mapping experiments due to the stochastic nature of single molecule interaction events.”


Furthermore, under Professor Suh’s guidance, the AFM is being interfaced with a homemade Raman spectroscopy system. 36782pr@reply-direct.com


The World’s Fastest Desktop SEM to Handle Large Samples


The Phenom XL from PhenomWorld pushes the boundaries of desktop SEM performance. It features the proven ease-of- use and fast time to image of all the Phenom systems [http://ilmt.co/ PL/wWb4]. Additionally, it is equipped with a chamber that despite its small size allows analysis and full imaging of large samples up to 100mm x 100mm. And yet, the Phenom XL is a desktop SEM that uses little energy, needs little space, and does not require special facilities.


The Phenom XL features various key innovations that enable this performance: a proprietary venting/loading mechanism that ensures the fastest vent/load cycle in the world. With a time-to- image of less than one minute, it provides the highest throughput. A newly developed compact motorised stage enables the user to scan the full sample area, and yet keep the SEM small enough to fi t on a standard table.


The user interface is based on proven technology used in the successful Phenom Pro and ProX desktop SEM’s. This enables both existing and new users


to quickly become familiar with the system and get the most of it without the need for signifi cant set-up or training. The ease-of-use is given an extra boost with a newly designed ‘single-shot’ optical navigation camera (NavCam) that allows the user to move to any spot on the sample with just a single click – within seconds.


Elemental analysis can be added by the EDS technology already proven on the Phenom ProX. An optional Secondary Electron Detector (SED) is available for applications that require surface and topography sensitive imaging.


34023pr@reply-direct.com One-Click Digital Slide Scanner Launched


Motic Instruments, the established manufacturer of Light Microscopes and microscope cameras, announces fi rst steps into the application fi eld of digital scanning. MoticEasyScan is an effi cient scanning instrument for producing and sharing high-quality digital images. Simple and easy, the implemented software allows untrained users a quick and reliable data acquisition: one click starts a complete scanning process. This conversion of glass slide information into digital data embodies several advantages. Safe storage of fragile information, sharing of clinical expertise and worldwide networking will have a great impact in any public health system.


Moreover, digitised slides are a fast and easily accessible tool for a modern style of university teaching. Hundreds of sample slides, some of them delicate and with rare cases can be delivered in an identical quality to every student. Typical characteristics, single anomalies: thanks to internet access students can work from home in an effi cient educational experience.


“The MoticEasyScan is dedicated to hospitals and institutes with a medium amount of slide samples to be treated. But also in university teaching it will fi nd an essential fi eld of application”, Dr. Hans-Jürgen Klemenz, Product Manager in Motic Europe, stated.


Maximum image quality is given by especially designed High NA Apochromatic objectives. The progressive scan mode ensures a long-lifetime by minimising moving parts. The 6-position slide tray accepts a wide slide dimension tolerance. As no high-priced glass slides are needed, running costs are cut back.


The MoticEasyScan will be available from winter 2015 on. Know more about it by visiting www.moticeasyscan.com 36672pr@reply-direct.com


The Weatherall Institute of Molecular Medicine (WIMM) at Oxford University comprises various groups involved in molecular medicine research forming a ‘Research Hotel’. They all come from different medical departments and also different topics, but their joint efforts within one place and the possibility to use state-of-the-art facilities shall optimise research efforts and bolster novel results.


Dr Marco Fritzsche works in the Nano-Immunology group of Professor Christian Eggeling in the MRC Human Immunology Unit (HIU) at the WIMM. Their specialty areas include cell mechanics and the use of FRAP.


In recent years, biomedical researchers have increasingly recognised the importance of forces within biological systems, ranging from the spreading of cancerous cells to the triggering of the immune system resulting in the atomic force microscope (AFM) being adopted by many research groups on a daily basis. However, to date, no system had been available within the Oxford microscope facilities serving biological research for directly measuring or enforcing forces on cells. The way cells interact with each other is often ruled by physical changes due to motion, so-called mechanical force. Such forces are present during molecular rearrangements and are observed most obviously when cells form close contacts, avoid each other or reshape to change morphology. Forces play an important role in many biomedical processes. The new JPK AFM setup will eventually be integrated into the image facility at the WIMM, offering the possibility for less-experienced users to address questions about force involvement in their biomedical research.


Dr Fritzsche and the Nano-Immunology group use a toolbox of different nanoscopy and microscopy techniques. This involves custom-built and commercially available microscopes such as Stimulated Emission Depletion (STED) microscopy, STORM, as well as confocal scanning, spinning disk microscopy, widefi eld technologies and TIRF. Moreover, they have implemented quantitative microscopy and spectroscopy methods such as FRAP, point FCS, scanning FCS, FLIM, and FRET.


Dr Fritzsche sees several benefi ts in choosing JPK´s system: “What is particularly important for our experiments is the ability of the JPK AFM NanoWizard®


to move the sample


instead of the head and the ability to pull and push with a dynamic range of 15 µm. This way, we can quantify the mechanical properties of the cells but also functionalise cantilevers with antibodies and receptor ligands and study the forces exerted by the immune cells in response to these ligands.”


37061pr@reply-direct.com


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INTERNATIONAL LABMATE - JANUARY/FEBRUARY 2016


Oxford University Combines AFM with a Toolbox of Microscopy Techniques


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