ceuticals that attempt to mimic or enhance the actions of sero- tonin in the brain. This approach supposes that there is not enough serotonin in the system. For some people this is the case. Many individuals find that the SSRIs help for a time, but eventually are not effective. If the individual has low serotonin to begin with, attempt- ing to trick the brain into thinking there is more will only go on for so long. Serotonin can be measured in the blood and urine. Restor- ing normal balance in this case may often involve supplementation with tryptophan or 5-HTP. This amino acid is converted by the cells lining the digestive tract into serotonin.
Digestion
Approximately 90% of the serotonin in the human body can be found in the digestive tract. Due to this, treatment of any digestive problems would very likely be helpful as well. This could include acid reflux, gas, bloating or constipation.
SAMe
Another nutrient commonly used to treat depression is S- Adenosyl-L-methionine or SAMe. Small studies have shown this nutrient, present in all cells, to be equally effective to older anti- depressant medications, and superior to placebo. Generally safe, without significant side effects, this can be a very helpful therapy. The exact mechanism of action for depression is unknown, however, researchers suspect that it may be due to its actions as a methyl donor. Molecules that readily give up their methyl groups are very useful in human cells. Many molecules require these methyl groups to be given to them in order to function optimally. One example of this is Folate. This well known B vitamin has been shown to be low in many individuals suffering with depression. The active form of this vitamin is called methyltetrahydrofolate. This is folate that has had a methyl group added to it. Perhaps by activating this and other molecules SAMe allows the body to restore normal function.
The Stress Hormone, Cortisol
A functional imbalance of cortisol may be an underlying cause for the symptoms of depression. Long-term effects of stress on the body cause our endocrine system to adapt by increasing the produc- tion of cortisol, which is our stress hormone. It’s partly responsible for our fight-or-flight response, our sleep/wake cycle, our metabo- lism, and inflammation. Over time, the production of cortisol may slow down or occur in an abnormal pattern; a phenomenon often referred to as adrenal fatigue. The total amount of cortisol may be
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